Optical and electrochemical dual-image CMOS sensor for on-chip biomolecular sensing applications

Tokuda, Takashi; Tanaka, Kazuhide; Matsuo, Masamichi; Kagawa, Keiichiro; Nunoshita, Masahiro

doi:10.1016/j.sna.2006.08.027

Cited by 55 publications

(52 citation statements)

References 7 publications

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“…In general, a greater exposure period gives a higher sensitivity, but it trades-off against the frame rate of the image sensor. The sensing performances of our active pixel sensor circuit were presented in our previous publication [14].…”

Section: Design Of the Implantable Cmos Image Sensor For Glucose Sensingmentioning

confidence: 99%

CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel

Tokuda

Takahashi

Uejima

et al. 2014

Biomed. Opt. Express

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A CMOS image sensor-based implantable glucose sensor based on an optical-sensing scheme is proposed and experimentally verified. A glucose-responsive fluorescent hydrogel is used as the mediator in the measurement scheme. The wired implantable glucose sensor was realized by integrating a CMOS image sensor, hydrogel, UV light emitting diodes, and an optical filter on a flexible polyimide substrate. Feasibility of the glucose sensor was verified by both in vitro and in vivo experiments.

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Section: Design Of the Implantable Cmos Image Sensor For Glucose Sensingmentioning

confidence: 99%

CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel

Tokuda

Takahashi

Uejima

et al. 2014

Biomed. Opt. Express

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“…Then, we demonstrated the The base chip is the multifunctional CMOS image sensor chip made of Si. Based on a conventional CMOS image sensor equipped with 3-transistor active pixel sensor as light sensing circuitry, we implemented a capability of addressable current injection (and electric sensing) capability [8,9]. Figure 2 shows (a) layout, (b) block diagram of the multifunctional CMOS image sensor.…”

Section: Introductionmentioning

confidence: 99%

An in vitro demonstration of CMOS-based optoelectronic neural interface device for optogenetics

Tokuda

Nakajima

Maezawa

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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A CMOS-based neural interface device equipped with an integrated micro light source array for optogenetics was fabricated and demonstrated. A GaInN LED array formed on sapphire substrate was successfully assembled with a multifunctional CMOS image sensor that is capable of on-chip current injection. We demonstrated a functionality of light stimulation onto ChR2-expressed cells in an in vitro experiment. A ChR2-expressed cell were successfully stimulated with the light emitted from the fabricated device.

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“…On the other hand, redox sensors of the current detection type are capable to monitor multi-ions simultaneously in one sensor [5]. Our group had been studied Redox array sensors [6][7][8][9] for imaging of cell activity and monitoring of environmental pollution. For the redox sensor, decrements of sensing area size and detection limit of ion concentration are the competing demands.…”

Section: Introductionmentioning

confidence: 99%

Proposition and fabrication of Amplified Redox Sensor (ARS) for high sensitive chemical analysis

Takahashi

Futagawa

Ishida

et al. 2013

2013 Transducers &Amp; Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems

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In recent years, many groups have been studying redox sensor for chemical analysis. The Redox sensor has some strong points such as detecting multi-ion at a sensing area and detecting concentration of materials by voltage and current signal. For the redox sensor, decrements of sensing area size and detection limit of ion concentration are the competing demands. In this study, proposed Amplified Redox Sensor (ARS) is achieved 75 times of amplification than without bipolar transistor and as low as 100μM potassium ferricyanide (K3 [Fe (CN) 6]) of concentration.

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Optical and electrochemical dual-image CMOS sensor for on-chip biomolecular sensing applications

Cited by 55 publications

References 7 publications

CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel

CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel

An in vitro demonstration of CMOS-based optoelectronic neural interface device for optogenetics

Proposition and fabrication of Amplified Redox Sensor (ARS) for high sensitive chemical analysis

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