Optical biosensors: a decade in review

Singh, Amit Kumar; Mittal, Shweta; Das, Mangal; Saharia, Ankur; Tiwari, Manish K.

doi:10.1016/j.aej.2022.12.040

Cited by 111 publications

(49 citation statements)

References 226 publications

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“…Optical biosensors focus on measurement of the optical signals as the changes in the optical properties and characteristics on the transducer surface in the case of an interaction of the immobilized biorecognition element with the measured substance [12]- [14]. Figure 1 shows a general illustration of an optical biosensor.…”

Section: Solid-phase Optical Sensors and Their Applications In Virus ...mentioning

confidence: 99%

Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection

Seymour¹,

Kanik²,

Gür³

et al. 2023

Preprint

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Viral infections can endanger public health by causing serious illness, leading to pandemics and burdening healthcare systems. Moreover, in the situation of a global spread, disruptions occur in every aspect of life including business, education, and social life. Fast and accurate diagnosis of viral infections has huge implications for saving people’s lives, preventing spread of the diseases, and minimizing social and economic damages. In the last decades, polymerase chain reaction (PCR) based techniques have been frequently used to detect viruses in the clinic. However, in a situation where rapid virus detection is the primary measure in preventing the spread, as in the case of ongoing COVID-19 pandemic, disadvantages of PCR, such as long processing times and requirement of sophisticated laboratory instruments, have been faced. Due to the urgent need for accurate techniques for virus detection, biosensor systems involved in many applications in biological detection are being developed for rapid, real-time, and high-throughput detection of viruses. Among various sensing platforms, optical devices are of great interest due to their advantages such as high sensitivity and direct readout. In the current review, usability of sensing techniques depending on optical phenomena, such as fluorescence-based sensors, surface plasmon resonance (SPR), surface enhanced Raman scattering (SERS), optical resonators and interferometry-based platforms, is discussed for virus diagnostics applications. Then, we focus on an interferometric biosensor developed by our group, single-particle interferometric reflectance imaging sensor (SP-IRIS), which has the capability to visualize single nanoparticles, to demonstrate its application for digital virus detection.

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Section: Solid-phase Optical Sensors and Their Applications In Virus ...mentioning

confidence: 99%

Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection

Seymour¹,

Kanik²,

Gür³

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…A high number of added zeros may be useful for some applications where the d-axis position of the peaks needs to be known as precisely as possible, for instance in order to deduce group indices. This aspect is not as important when trying to determine loss coefficients for which only amplitude accuracy is relevant, as shown in equation (1). Instead of their amplitude, one could also use the peak areas for the loss calculation.…”

Section: Influence Of Data Preparationmentioning

confidence: 99%

“…In any optics or photonics system detailed knowledge of the optical loss of individual components is a prerequisite to optimizing performance. This could be to stay competitive on the market, to preserve light coming from weak sources, as is often the case in biosensing [1,2] and whenever light cannot simply be amplified like light signals transmitted via free-space links [3] or quantum states of light [4]. Quantifying these losses, however, can prove difficult; especially in integrated semiconductor devices.…”

Section: Introductionmentioning

confidence: 99%

A practical guide to loss measurements using the Fourier transform of the transmission spectrum

Thiel,

Nardi,

Schlager

et al. 2023

J. Phys. Photonics

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Analyzing the internal loss characteristics and multimodedness of (integrated) optical devices can prove difficult. One technique to recover this information is to Fourier transform the transmission spectrum of optical components. This article gives instruction on how to perform the transmission measurement, prepare the data, and interpret the Fourier spectrum. Our guide offers insights into the influence of sampling, windowing, zero padding as well as Fourier spectrum peak heights and shapes which are previously neglected in the literature but have considerable impact on the results of the method. For illustration, we apply the method to a Bragg-reflection waveguide. We find that the waveguide is multimodal with two modes having very similar group refractive indices but different optical losses.

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“…As a case in point, the continuous glucose monitor has undoubtedly improved both the life expectancy and quality of life for individuals with Type I diabetes . Beyond this well-known, commercialized example, electrochemical biosensors are being developed for biomedical applications, including cancer cell detection, biomarker tracking, blood alcohol analysis, and therapeutic drug monitoring. , Thanks to their desirable functional properties like low cost, , compatibility with biological fluids, , and inherent analytical capabilities, electrochemical biosensors are ideal candidates for clinical translation. As examples of potential future uses, these sensors could be interfaced with wound dressings to monitor inflammation and infection .…”

Section: Introductionmentioning

confidence: 99%

Survey of Conductive Polymers for the Fabrication of Conformation Switching Nucleic Acid-Based Electrochemical Biosensors

Shaver,

Mallires,

Harris

et al. 2023

ACS Appl. Polym. Mater.

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Electrochemical biosensors are a continuously evolving technology with great potential for applications in human health. With the continuous glucose monitor as an example, these sensors are capable of accurately determining molecular concentrations directly in the human body. A specific class of biosensors, termed conformation switching nucleic acid-based electrochemical sensors (NBEs), relies on the affinity of oligonucleotides for molecular recognition and their conformational dynamics upon target binding for signal generation. Currently, most NBEs are fabricated via the self-assembly of alkylthiol monolayers on Au electrodes. However, this architecture is limited in terms of stability and the breadth of supporting materials with which it is compatible. Here, to explore alternative material options for the fabrication of NBE sensors, we form conductive polymers of aromatic amines, thiophenes, and pyrroles on platinum electrodes. Altering many parameters throughout the study, we determine the extent to which the polymers passivate the electrode surface and then couple redox reporters or reporter-modified nucleic acids. We discuss the limitations and benefits of each polymer for the formation of NBE sensors and provide future directions to continue the quest for alternative sensor materials.

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Optical biosensors: a decade in review

Cited by 111 publications

References 226 publications

Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection

Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection

A practical guide to loss measurements using the Fourier transform of the transmission spectrum

Survey of Conductive Polymers for the Fabrication of Conformation Switching Nucleic Acid-Based Electrochemical Biosensors

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