Optical Biosensors for Therapeutic Drug Monitoring

Garzón, Vivian; Pinacho, Daniel G.; Bustos, Rosa-Helena; Garzón, Gustavo; Bustamante, Sandra

doi:10.3390/bios9040132

Cited by 78 publications

(39 citation statements)

References 181 publications

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“…These devices focus on the measurement of optical properties and characteristics of the transducer surface when occurring the interaction of the analyte with the recognition element. [16] , [17] , [18] , [19] . Piezoelectric biosensors employ transducers that resonate when an external alternating electrical field is applied.…”

Section: Biosensorsmentioning

confidence: 99%

Biosensors for the detection of respiratory viruses: A review

Cordeiro²,

et al. 2020

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Highlights A review containing the newest contributions of biosensors for respiratory viruses’ detection is presented. Influenza virus, coronavirus and respiratory syncytial virus were extensively analyzed. Tables containing biosensors information regarding the detection of the viruses are presented. Discussion based on the new trends and authors accomplishments are applied. SARS-CoV-2 biosensors already published were included and analyzed.

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Section: Biosensorsmentioning

confidence: 99%

Biosensors for the detection of respiratory viruses: A review

Cordeiro²,

et al. 2020

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“…TDM helps to decrease PK variability (effects caused by the organism on the drug, in terms of absorption, bioavailability, distribution, metabolism, and excretion) and PD variability (effects of the drug on the organism, studying receptor binding and chemical interactions) [ 161 ]. According to WHO reports, certain criteria allow for determining whether a drug needs to be monitored, including: (i) pharmacokinetic variability, (ii) adverse and therapeutic effects related to concentration, (iii) narrow therapeutic index, (iv) undefined range of therapeutic concentration, and (v) difficult to control desired therapeutic effect ( Figure 2 ) [ 6 , 10 ].…”

Section: Therapeutic Drug Monitoring (Tdm)mentioning

confidence: 99%

“…Monitoring techniques include single or mass-coupled chromatographic methods with a variety of detectors, including ultraviolet or fluorescent detectors (specified below) and immunoassays [ 10 , 11 ]. Many of these techniques have been approved by the Food and Drug Administration (FDA) of the United States [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring

Garzón

Bustos

Pinacho

2020

JPM

Self Cite

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Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in different body fluids, such as blood, plasma, serum, and urine, among others. Using different techniques that allow for the pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the drug, TDM can reduce the risks inherent in treatment. Among these techniques, nanotechnology focused on biosensors, which are relevant due to their versatility, sensitivity, specificity, and low cost. They provide results in real time, using an element for biological recognition coupled to a signal transducer. This review describes recent advances in the quantification of AB using biosensors with a focus on TDM as a fundamental aspect of personalized medicine.

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“…Indeed, TDM possesses immense potential that largely remains untapped (Garzón et al, 2019). Knowledge of drug serum concentrations through TDM allow clinicians and pharmacist to adjust the next scheduled dose, ensuring that drug concentrations are kept within the therapeutic window.…”

Section: Introductionmentioning

confidence: 99%

Optical biosensors - Illuminating the path to personalized drug dosing

Ong

Pollard

Goyanes

et al. 2021

Biosensors and Bioelectronics

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Optical biosensors are low-cost, sensitive and portable devices that are poised to revolutionize the medical industry. Healthcare monitoring has already been transformed by such devices, with notable recent applications including heart rate monitoring in smartwatches and COVID-19 lateral flow diagnostic test kits. The commercial success and impact of existing optical sensors has galvanized research in expanding its application in numerous disciplines. Drug detection and monitoring seeks to benefit from the fast-approaching wave of optical biosensors, with diverse applications ranging from illicit drug testing, clinical trials, monitoring in advanced drug delivery systems and personalized drug dosing. The latter has the potential to significantly improve patients' lives by minimizing toxicity and maximizing efficacy. To achieve this, the patient's serum drug levels must be frequently measured. Yet, the current method of obtaining such information, namely therapeutic drug monitoring (TDM), is not routinely practiced as it is invasive, expensive, time-consuming and skilled labor-intensive. Certainly, optical sensors possess the capabilities to challenge this convention. This review explores the current state of optical biosensors in personalized dosing with special emphasis on TDM, and provides an appraisal on recent strategies. The strengths and challenges of optical biosensors are critically evaluated, before concluding with perspectives on the future direction of these sensors.

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Optical Biosensors for Therapeutic Drug Monitoring

Cited by 78 publications

References 181 publications

Biosensors for the detection of respiratory viruses: A review

Biosensors for the detection of respiratory viruses: A review

Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring

Optical biosensors - Illuminating the path to personalized drug dosing

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