Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Abstract

The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5-2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9-76.5% of that of normal skin.

An absence of imperfections: A proposed framework for defining, assessing, and achieving skin glow

“…However, skin glow is affected by more than just the surface integrity of the skin. The appearance of the skin is determined by absorption of light (hemoglobin and melanin) and scattering of light is due to organic structures such as mitochondria and collagen fibers 19,21 . The group agreed that the depth of the skin should also be considered because the dense collagen texture gives the reflection a halo‐like glow.…”

“…The appearance of the skin is determined by absorption of light (hemoglobin and melanin) and scattering of light is due to organic structures such as mitochondria and collagen fibers. 19,21 The group agreed that the depth of the skin should also be considered because the dense collagen texture gives the reflection a halo-like glow. On this basis, they supported the concept that when there is an uninterrupted dermal light reflection in normal or rejuvenated tissue a milky homogenous appearance results from light bouncing of collagen, 9,10 and this also contributes to skin glow.…”

Alterações Dermatológicas Durante Tratamento Oncológico de Mulheres com Câncer de Mama: Estudo em Prontuários Clínicos

“…A literatura reporta que o uso de taxanos, como paclitaxel, pode estar associado ao surgimento dessas alterações, seja de forma localizada ou generalizada. O início da hiperpigmentação em mulheres com câncer de mama varia entre semanas e meses após o início da terapia oncótica, embora pacientes que recebem 5-fluorouracil possam apresentar início mais rápido 20,21 . Também é possível que a hiperpigmentação na pele seja secundária ao aumento da quantidade da melanina, carotenos ou hemoglobinas 5 .…”

“…Relatos de hiperpigmentações associadas à terapia antineoplásica indicam que essas alterações dermatológicas podem ocorrer em diferentes padrões e acometem diversas regiões do corpo, como a palma das mãos e a planta dos pés, permanecendo ao longo do tratamento quimioterápico. De modo generalista, hiperpigmentações também podem provocar redução da autoestima e qualidade de vida 20,21 . Habitualmente, desaparecem após meses ou anos da descontinuidade da droga desencadeante.…”

Measurement of optical properties of human skin in the ultraviolet wavelength range: age-related changes

“…Therefore, it is essential to know the optical properties, scattering and absorption coefficients, of the skin in the UV wavelength range to improve the treatment strategy. Our group has been developing a non-invasive method, reflection spatial profile method (RSPM), for measuring optical properties of skin and elucidated optical property differences arising out of cancer drugs [1] . In this study, we have developed a novel system that operates in the range of UV wavelengths irradiating the skin with a structured incoherent source and detecting the reflected light with a CCD camera.…”