Optical characterization of molecular interaction strength in protein condensates
Timon Beck,
Lize-Mari van der Linden,
Wade M. Borcherds
et al.
Abstract:Biomolecular condensates have recently been identified as a ubiquitous means of intracellular organization. Investigating the molecular interactions determining the formation, and physical properties of biomolecular condensates provides key insights for understanding their biological function, and dysfunction. Here, we applied Brillouin microscopy and quantitative phase imaging to quantify average molecular interaction strength, dry mass density, and protein volume fraction in protein condensates in vitro. We … Show more
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