Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Larin, Kirill V.; Sampson, David D.

doi:10.1364/boe.8.001172

Cited by 368 publications

(270 citation statements)

References 198 publications

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“…10 Excitation sources include acoustic radiation force (ARF), air-pu® excitation, laser-based thermal expansion, and needles connected to piezoelectric vibrators, to name just a few. 11 By tracking the propagating wave, Young's modulus and other biomechanical parameters can be calculated based on the estimation of the wave speed and the selection of the correct wave propagation model dictated by the boundary conditions of the sample. 11 Unfortunately, in many dispersive lossy tissues, propagation of shear or surface waves will be rapidly damped and distorted, complicating the attempts of estimating wave speed by using typical methodologies such as peak tracking.…”

Section: Introductionmentioning

confidence: 99%

An approach to viscoelastic characterization of dispersive media by inversion of a general wave propagation model

Zvietcovich

Rolland

Parker

2017

J. Innov. Opt. Health Sci.

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In the characterization of elastic properties of tissue using dynamic optical coherence elastography, shear/surface waves are propagated and tracked in order to estimate speed and Young's modulus. However, for dispersive tissues, the displacement pulse is highly damped and distorted during propagation, diminishing the e®ectiveness of peak tracking approaches, and leading to biased estimates of wave speed. Further, plane wave propagation is sometimes assumed, which contributes to estimation errors. Therefore, we invert a wave propagation model that incorporates propagation, decay, and distortion of pulses in a dispersive media in order to accurately estimate its elastic and viscous components. The model uses a general¯rst-order approximation of dispersion, avoiding the use of any particular rheological model of tissue. Experiments are conducted in elastic and viscoelastic tissue-mimicking phantoms by producing a Gaussian push using acoustic radiation force excitation and measuring the wave propagation using a Fourier domain optical coherence tomography system. Results con¯rmed the e®ectiveness of the inversion method in estimating viscoelastic parameters in both the viscoelastic and elastic phantoms when compared to mechanical measurements. Finally, the viscoelastic characterization of a fresh porcine cornea was conducted. Preliminary results validate this approach when compared to other methods.

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Section: Introductionmentioning

confidence: 99%

An approach to viscoelastic characterization of dispersive media by inversion of a general wave propagation model

Zvietcovich

Rolland

Parker

2017

J. Innov. Opt. Health Sci.

View full text Add to dashboard Cite

show abstract

“…A number of optical elastography techniques have been developed, based on, for example, optical coherence tomography (OCT) [7], Brillouin microscopy [8] and laser speckle microscopy [9]. Optical coherence elastography (OCE) [10][11][12], in particular, holds promise for in vivo imaging of tissue mechanics due to its combination of high resolution, rapid imaging speed and compatibility with compact imaging probes [13].…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics

Fang¹,

Curatolo²,

Wijesinghe³

et al. 2017

Biomed. Opt. Express

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Abstract:In this paper, we describe a technique capable of visualizing mechanical properties at the cellular scale deep in living tissue, by incorporating a gradient-index (GRIN)-lens microendoscope into an ultrahigh-resolution optical coherence elastography system. The optical system, after the endoscope, has a lateral resolution of 1.6 µm and an axial resolution of 2.2 µm. Bessel beam illumination and Gaussian mode detection are used to provide an extended depth-of-field of 80 µm, which is a 4-fold improvement over a fully Gaussian beam case with the same lateral resolution. Using this system, we demonstrate quantitative elasticity imaging of a soft silicone phantom containing a stiff inclusion and a freshly excised malignant murine pancreatic tumor. We also demonstrate qualitative strain imaging below the tissue surface on in situ murine muscle. The approach we introduce here can provide high-quality extended-focus images through a micro-endoscope with potential to measure cellular-scale mechanics deep in tissue. We believe this tool is promising for studying biological processes and disease progression in vivo. high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12(11), 2404-2422 (2004

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“…Advantages of OCE over other elastography techniques, such as magnetic resonance elastography [1] and ultrasound elastography [2], include its higher spatial resolution (10-100 µm), enabling detection of smaller features, and its sensitivity to nano-scale displacements (afforded by phase-sensitive detection [3]), providing the potential for improved sensitivity to changes in mechanical properties. OCE has progressed rapidly over the last few years [4][5][6] and has been proposed for a range of applications, including in oncology [7,8], ophthalmology [9] and cardiology [10]. However, to date, the majority of OCE demonstrations have been limited to tissue-mimicking phantoms and excised tissues.…”

Section: Introductionmentioning

confidence: 99%

In vivo volumetric quantitative micro-elastography of human skin

Es'haghian¹,

Kennedy²,

Gong³

et al. 2017

Biomed. Opt. Express

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Abstract:In this paper, we demonstrate in vivo volumetric quantitative micro-elastography of human skin. Elasticity is estimated at each point in the captured volume by combining local axial strain measured in the skin with local axial stress estimated at the skin surface. This is achieved by utilizing phase-sensitive detection to measure axial displacements resulting from compressive loading of the skin and an overlying, compliant, transparent layer with known stress/strain behavior. We use an imaging probe head that provides optical coherence tomography imaging and compression from the same direction. We demonstrate our technique on a tissue phantom containing a rigid inclusion, and present in vivo elastograms acquired from locations on the hand, wrist, forearm and leg of human volunteers. References and links1. R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, "Magnetic resonance elastography by direct visualization of propagating acoustic strain waves," Science 269(5232), 1854-1857 (1995 3236-3245 (2015). Burns 22(6), 443-446 (1996 785-791 (1990). 14. C. Escoffier, J. de Rigal, A. Rochefort, R. Vasselet, J. L. Lévêque, and P. G. Agache, "Age-related mechanical properties of human skin: an in vivo study," J. Invest. Dermatol. 93(3), 353-357 (1989). 15. C. Li, G. Guan, R. Reif, Z. Huang, and R. K. Wang, "Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography," J. R.

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Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Cited by 368 publications

References 198 publications

An approach to viscoelastic characterization of dispersive media by inversion of a general wave propagation model

An approach to viscoelastic characterization of dispersive media by inversion of a general wave propagation model

Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics

In vivo volumetric quantitative micro-elastography of human skin

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