Optical coherence tomographic findings of dissociated optic nerve fiber layer appearance

Mitamura, Yoshinori; Kinoshita, Takamasa; Miyano, Nagako; Tashimo, Asako; Ohtsuka, Kenji

doi:10.1016/j.ajo.2004.01.052

Cited by 75 publications

(73 citation statements)

References 4 publications

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“…SD-OCT imaging of the DONFL appearance in our study provided different cross-sectional images. The defects of the innermost retinal layer were more deepened toward the outer retinal layer than postoperative focal RNFL defects reported in previous studies [20,21] (fig. 2).…”

Section: Discussionmentioning

confidence: 62%

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Morphological Change of Inner Retinal Layer on Spectral-Domain Optical Coherence Tomography following Macular Hole Surgery

Kim

et al. 2013

Ophthalmologica

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Background/Aims: To investigate the morphological changes of the inner retinal layer by spectral-domain optical coherence tomography (OCT) after idiopathic full-thickness macular hole (MH) surgery. Methods: In a retrospective study, the authors evaluated 52 eyes of 49 patients with MH closed following vitrectomy. All patients were followed postoperatively for more than 6 months. Cross-sectional and retinal surface images were obtained using Cirrus high-definition OCT before and after surgery. In 24 of the 52 eyes, fundus autofluorescence (FAF) was analyzed. Results: The incidence of dissociated optic nerve fiber layer (DONFL) increased gradually over time after surgery. 57.7% had defects of only the retinal nerve fiber layer (RNFL) and 30.8% had defects in the inner plexiform layer at 6 months after surgery. Postoperative best-corrected visual acuity did not differ significantly based on the depth of the DONFL (p = 0.299). There were no changes in FAF in the area with DONFL. Conclusions: DONFL is characterized by progressive defects that are not limited to RNFL thickness. The healing process after vitrectomy for MH is not limited in the RNFL affecting deeper structural changes. Further investigations are required to evaluate the pathophysiological mechanism of inner retinal change after MH surgery.

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Section: Discussionmentioning

confidence: 62%

“…In previous studies, the DONFL appearance was characterized as a focal defect of the RNFL in cross-sectional images obtained using TD-OCT [11,14,20]. SD-OCT imaging of the DONFL appearance in our study provided different cross-sectional images.…”

Section: Discussionmentioning

confidence: 99%

Morphological Change of Inner Retinal Layer on Spectral-Domain Optical Coherence Tomography following Macular Hole Surgery

Kim

et al. 2013

Ophthalmologica

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“…7,8 They suggested that the dimples are caused by a cleavage of the optic nerve fi ber bundle due to damage to the Müller cells that occurred when the ILM was peeled. However, they only compared the sensitivity of two points: the arcuate striae area and the surrounding normal retinal area midway between the papilla and macula.…”

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confidence: 98%

Microperimetric determination of retinal sensitivity in areas of dissociated optic nerve fiber layer following internal limiting membrane peeling

Imai

Ohta

2010

Jpn J Ophthalmol

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“…There have been studies showing that the retinal nerve fiber layer changes after idiopathic MH surgery. [8][9][10] Thus, the purpose of this study was to determine whether the GCC becomes thinner after ILM peeling for an MH. The relationship between retinal sensitivity and the GCC thickness was also determined.…”

Section: Introductionmentioning

confidence: 99%

Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole

Baba

Yamamoto

Kimoto

et al. 2012

Eye

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Optical coherence tomographic findings of dissociated optic nerve fiber layer appearance

Cited by 75 publications

References 4 publications

Morphological Change of Inner Retinal Layer on Spectral-Domain Optical Coherence Tomography following Macular Hole Surgery

Morphological Change of Inner Retinal Layer on Spectral-Domain Optical Coherence Tomography following Macular Hole Surgery

Microperimetric determination of retinal sensitivity in areas of dissociated optic nerve fiber layer following internal limiting membrane peeling

Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole

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