Optical coherence tomographic predictor of retinal non-perfused areas in eyes with macular oedema associated with retinal vein occlusion

Hasegawa, Taiji; Yamashita, Mariko; Maruko, Ichiro; Koizumi, Hideki; Kogure, Akiko; Ogata, Nahoko; Iida, Tomohiro

doi:10.1136/bjophthalmol-2016-308813

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…Podkowinski found that all 3 different retinal compartment layers were thinner in the atrophy group than in the control group [ 20 ]. Hasegawa found that low reflective spaces in the retinal nerve fibre layer could predict full RT and inner RT thinning in BRVO patients [ 19 ]. Our findings indicate that necrotic or apoptotic changes of cells simultaneously happened in superficial and deep retinal layers due to a decrease in both SVC-VD and DVC-VD.…”

Section: Discussionmentioning

confidence: 99%

“…In the single linear regression model, we found that VA with complete resolution of MO was positively correlated with quadrantal SVC-VD, but not quadrantal DVC-VD. The reason might be apoptotic or necrotic changes of RNFL, which receives its blood supply from SVC and plays an important role in VA [ 19 ]. And the reason why we could not find a significant correlation between VA and DVC-VD might be the small sample in our study and the fluctuation of the nature of OCTA readings.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggested that retinal atrophy caused by severe ischemia resulted in a lower recurrence rate or less severity of MO, indicating that atrophy might lead to anatomic and functional changes of retina [ 17 – 19 ]. Podkowinski defined retinal atrophy as RT < 260 μ m outside the foveal center [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Structural and Visual Changes in Branch Retinal Vein Occlusion Patients with Retinal Atrophy

Song

et al. 2022

Journal of Ophthalmology

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Background. To study the changes of retinal vascular density (VD), retinal thickness (RT), and their correlations with visual acuity (VA) in branch retinal vein occlusion (BRVO) patients with retinal atrophy after resolution of macular oedema (MO). Methods. This is a retrospective study consisting of 46 patients diagnosed with BRVO at Beijing Hospital from 2015 to 2019. Patients’ 46 affected eyes and 39 fellow eyes were included. The affected eyes were further divided into the atrophy group and the nonatrophy group. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) images obtained when MO completely resolved after treatment with ranibizumab were analyzed. We quantitatively measured foveal avascular zone (FAZ) parameters, the disruption extent of ellipsoid zone (EZ), RT, and VD of superficial vascular complex (SVC), and deep vascular complex (DVC) in central fovea and the minimal-VD quadrant. Paired t-tests, independent t-tests, Mann–Whitney U tests, Wilcoxon tests, Pearson correlation analyses, Spearman correlation analyses, and single and multiple linear regression models were adopted. Results. Compared with nonatrophy eyes, the minimal-VD quadrantal (quadrantal for short) SVC-VD (25.76 ± 4.57% versus 36.21 ± 6.47%, P < 0.001 ) and quadrantal DVC-VD (27.72 (17.23) % versus 38.95 (11.05) %, P = 0.001 ) of atrophy eyes decreased significantly. Quadrantal SVC-VD and quadrantal DVC-VD were strongly correlated with quadrantal full RT (r = 0.763 and 0.698, both P < 0.001 ). The disruption length of EZ was significantly correlated with quadrantal full RT (r = −0.406, P = 0.005 ) and quadrantal SVC-VD (r = −0.298, P = 0.044 ). In multiple linear regression analysis, the disruption length of EZ and VA before treatment and age showed significant correlations with VA with complete resolution of MO ( P = 0.020 , 0.033 , and 0.002 ). Conclusions. The retinal VD on the affected area correlates well with the corresponding full RT when BRVO-MO completely resolves, suggesting that VD may predict the final RT. Severe decrease in VD may result in retinal atrophy, which may cause VA loss indirectly with the intermediate influencing factor of EZ defects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Structural and Visual Changes in Branch Retinal Vein Occlusion Patients with Retinal Atrophy

Song

et al. 2022

Journal of Ophthalmology

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“…Furashova were observed in BRVO eyes after 2 years of follow-up and cannot be used in the acute phase. A recent study of Hasegawa et al 24 described a significant correlation of low reflective spaces in the RNFL with the presence of non-perfused areas on FA in RVO. It has been postulated that these spaces could be apoptotic changes in the RNFL due to retinal nonperfusion.…”

Section: Dovepressmentioning

confidence: 92%

<p>Hyperreflectivity of Inner Retinal Layers as a Quantitative Parameter of Ischemic Damage in Acute Retinal Vein Occlusion (RVO): An Optical Coherence Tomography Study</p>

Furashova¹,

Matthé²

2020

OPTH

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Purpose: To investigate the reflectivity changes of inner retinal layers in acute retinal vein occlusion (RVO) on spectral-domain optical coherence tomography (SD-OCT) and to correlate these values with other known parameters of acute ischemic damage. Patients and Methods: In this retrospective and observational case series, 230 eyes from 115 patients with acute RVO (central or branch) were categorized as ischemic or nonischemic depending on fluorescein angiography (FA) images at baseline. Thickness and reflectivity of selected retinal layers were measured from SD-OCT images at baseline. Reflectivity values were correlated with other parameters of acute ischemic damage (bestcorrected visual acuity (BCVA), retinal thickness, extent of macular edema, ischemic area on fluorescein angiography). The data were compared with contralateral eyes (controls). Prominent middle limiting membrane sign (p-MLM) was also registered. Results: RVO reflectivity values differed significantly in all retinal layers compared to controls (P<0.001). Ischemic RVO eyes had higher optical intensity values for the innermost retinal layer (IMRL; P=0.008) and inner retinal layer (P=0.019) compared to non-ischemic cases. For all RVO eyes as well as central RVO, severity parameters like BCVA, central and total retinal thickness showed a strong correlation with the IMRL reflectivity. In branch RVO, BCVA remained significantly correlated with the IMRL reflectivity, while the thickness values showed significant correlation only for central foveal thickness in non-ischemic branch RVO type. The p-MLM was seen on OCT in 94% of the ischemic and in 66% of the non-ischemic RVO cases. Conclusion: Acute RVO leads to increased reflectivity of inner retinal layers with significantly higher values in the ischemic vs non-ischemic type. Increased inner retinal layers' reflectivity correlated significantly with BCVA, retinal thickness of separate retinal layers, as well as ischemic area on FA. Quantitative non-invasive measurement of inner retinal layers' reflectivity might be used to determine the extent of acute ischemic retinal damage in RVO.

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“…First, in eyes with a large reduction in the macular VD, the number of capillaries decreases, which results in fewer leakages and may account for the lack of macular oedema 27 ; secondly, due to eyes with large macular non-perfused areas rapidly progress to a thinning of inner retina and result in reduction of oxygen consumption, which maintain balance between oxygen supply and consumption. 28 The above factors may cause less recurrence of macular edema in the resolved group.…”

Section: Research On the Role Of Octa In Following-up After Treatment...mentioning

confidence: 99%

Research progress of UWFFA and OCTA in retinal vein occlusion: A review

Han

2021

European Journal of Ophthalmology

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Retinal vein occlusion (RVO) is a retinal vascular disease that severely impairs the visual function of patients. Observing the changes of retinal blood vessels before and after treatment is of great significance for the prognostic evaluation of RVO. The rapid development and widespread use of fundus imaging technique, especially ultra-wide-angle fundus fluorescein angiography (UWFFA) and optical coherence tomography angiography (OCTA) have made our observation of the retinal blood vessels of RVO more comprehensive and meticulous. In this paper, we reviewed the latest research progress of UWFFA and OCTA in RVO.

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Optical coherence tomographic predictor of retinal non-perfused areas in eyes with macular oedema associated with retinal vein occlusion

Abstract: The presence of low reflective spaces in the RNFL in the OCT images can predict the presence of retinal non-perfused areas in eyes with macular oedema associated with a RVO.

Cited by 10 publications

References 26 publications

Structural and Visual Changes in Branch Retinal Vein Occlusion Patients with Retinal Atrophy

Structural and Visual Changes in Branch Retinal Vein Occlusion Patients with Retinal Atrophy

<p>Hyperreflectivity of Inner Retinal Layers as a Quantitative Parameter of Ischemic Damage in Acute Retinal Vein Occlusion (RVO): An Optical Coherence Tomography Study</p>

Research progress of UWFFA and OCTA in retinal vein occlusion: A review

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