Optical coherence tomography angiography and Humphrey visual field in patients with obstructive sleep apnea

Davanian, Arash; Williamson, Lindsay; Taylor, Caitlen; Harrover, Abigail; Bollinger, Kathryn E.; Chaudhary, Bashir A.; Taskar, Varsha; Lee, Tae Jin; Liu, Yuhan; Chen, Qingxia; Marcus, Dennis M.

doi:10.5664/jcsm.10054

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…Additionally, one study showed the thinning of the RNFL superotemporally by 1.5 µm with an increase in the apnea-hypopnea index by 5 events per hour [ 19 ]. Several studies have described the occurrence of OSA in patients with glaucoma [ 12 , 20 , 21 , 22 ]. One study demonstrated that patients with severe OSA had >8 times RNFL thickness progression than patients with none or mild OSA [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Glaucoma Is Associated with the Risk of Obstructive Sleep Apnea: A Population-Based Nationwide Cohort Study

Lee

Kim

2022

Diagnostics

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The association between glaucoma and the risk of obstructive sleep apnea (OSA) has not been fully evaluated. Therefore, this study aimed to investigate the prospective association between glaucoma and OSA. In total, 1437 patients with glaucoma and 5748 patients without glaucoma were enrolled after 1:4 propensity score matching using a nationwide cohort sample. We investigated OSA events during a 10-year follow-up period. Survival analysis, the log-rank test, and Cox proportional hazards regression models were used to calculate the incidence, disease-free survival rate, and hazard ratio (HR). The incidence of OSA was 12,509.0 person-years among those with glaucoma. The adjusted HR for patients with glaucoma developing OSA events during the follow-up period was 1.52 (95% confidence interval [CI]: 0.64–3.621) after other covariates. In a subgroup analysis, primary angle-closure glaucoma (PACG) showed a significantly increased adjusted HR for OSA events (5.65, 95% CI: 1.65–19.41), whereas we could not find any significant association between primary open-angle glaucoma (POAG) and OSA. The adjusted HR of OSA events in POAG was considerably increased 4 years after POAG diagnosis. PACG may be associated with an increased incidence of OSA. Clinicians should pay attention to early detection of OSA in patients with PACG.

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Section: Discussionmentioning

confidence: 99%

Glaucoma Is Associated with the Risk of Obstructive Sleep Apnea: A Population-Based Nationwide Cohort Study

Lee

Kim

2022

Diagnostics

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“…[6][7][8] In contrast, patients with glaucoma are more susceptible than healthy people to sleep dysfunction such as obstructive sleep apnea (OSA), snoring, or insomnia. [9][10][11][12][13] Despite increasing evidence from observational studies suggesting a correlation between sleep behaviors and POAG, there have also been several clinical studies reporting no association between them, [14][15][16] with the existing literature on the subject being inconclusive and debatable. Additionally, whether demographics, socioeconomic status, and comorbidities are potential confounding factors in this relationship remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Causal Relationship Between Sleep Behaviors and Primary Open-Angle Glaucoma: A Bidirectional Two-Sample Mendelian Randomization Study

Zhang,

Chen,

Zhu

et al. 2024

NSS

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Background Although previous studies of sleep-related behaviors in relation to primary open-angle glaucoma (POAG) have been noted, the causal relationship remains unclear. The purpose of our present study was to investigate the relationships of genetically predicted sleep traits with POAG using a two-sample bidirectional Mendelian randomization (MR) method. Methods Summary-level data collected from publicly available genome-wide association studies (GWAS) of European decent were applied for the bidirectional MR analysis. After quality control steps, independent single-nucleotide polymorphisms for eight sleep behaviors and POAG were selected as the genetic instruments. The inverse-variance weighted (IVW) approach was adopted as the primary method, which was complemented by a series of sensitivity analyses to assess the robustness of the results by estimating heterogeneity and pleiotropy. Multivariable MR (MVMR) was used to assess the direct effect of sleep traits on POAG, after adjusting for several confounding factors. Results Our investigation revealed a positive correlation between genetically predicted ease of getting up in the morning and sleep duration and POAG using the IVW method (odds ratio (OR)=1.78, 95% confidence interval (CI):1.29–2.46, P = 4.33× 10 −4 ; OR = 1.66, 95% CI:1.18–2.34, P = 3.38×10 −3 , respectively). Other supplementary MR methods also confirmed similar results. Moreover, the MVMR results also revealed that the adverse effects of these two sleep traits on POAG persisted after adjusting for body mass index, smoking, drinking, and education (all P < 0.05). Conversely, the relationships between genetic liability of POAG and different sleep behaviors were not statistically significant in the reverse-direction MR estimate (all P > 0.05). Conclusion Our study demonstrated that genetic prediction of getting up easily in the morning or sleep duration were associated with a higher risk of POAG, but not vice versa, in a European population. Further validation and clinical interventions are required to offer potential strategies to prevent and manage POAG.

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Associations between Nocturnal Hypoxemia and Retinal Nerve Fiber Layer Thinning: The Nagahama Study

Nagasaki,

Miyake,

Sato

et al. 2024

Annals ATS

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Optical coherence tomography angiography and Humphrey visual field in patients with obstructive sleep apnea

Cited by 4 publications

References 38 publications

Glaucoma Is Associated with the Risk of Obstructive Sleep Apnea: A Population-Based Nationwide Cohort Study

Glaucoma Is Associated with the Risk of Obstructive Sleep Apnea: A Population-Based Nationwide Cohort Study

Investigating the Causal Relationship Between Sleep Behaviors and Primary Open-Angle Glaucoma: A Bidirectional Two-Sample Mendelian Randomization Study

Associations between Nocturnal Hypoxemia and Retinal Nerve Fiber Layer Thinning: The Nagahama Study

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