Optical coherence tomography-angiography as a non-invasive method of pathology diagnosis of the microcirculatory bed of the optic nerve and macula

Krivosheeva, M.S.; Иойлева, Е. Э.

doi:10.21516/2072-0076-2021-14-2-90-95

Rossijskij oftalʹmologičeskij žurnal

2021

DOI: 10.21516/2072-0076-2021-14-2-90-95

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Optical coherence tomography-angiography as a non-invasive method of pathology diagnosis of the microcirculatory bed of the optic nerve and macula

M.S. Krivosheeva¹,

Е. Э. Иойлева

Abstract: The review discusses the development of optical coherence tomography with the function of angiography, focusing on its advantages, features, and prospects for the diagnosis of fundus pathologies.

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Cited by 4 publications

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The Result of the Treatment of Optic Nerve Edema after COVID-19

Ioyleva,

Safonenko,

Otyrba

et al. 2023

Oftalʹmologiâ

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The neuro-ophthalmic symptoms and signs associated with COVID-19 infection are varied and span the course of the infection to the convalescent phase. In addition to the anterior segment of the eye, there is a possibility of damage to the posterior segment of the eyeball. The described cases are isolated and there are no results of treatment of patients who have undergone COVID-19.Purpose: To describe the outcome of treatment of bilateral optic nerve edema after COVID-19.Methods. A 59-year-old man with reduced visual functions in the post-surgical period was examined. A standard ophthalmological examination was performed. In addition, spectral optical coherence tomography (OCT) of the macular area of the retina and optic disc (OND) was performed using the RTVue XR Avanti apparatus (Optovue, USA). The patient underwent a laboratory study.Results. Bilateral papilledema was detected in a patient after COVID-19. According to OCT data, a thickening of the nerve fiber layer of the retina of both eyes was revealed, according to OCT angiography, a decrease in the density of the RPC. Conducted a course of conservative and physiotherapy treatment.Conclusion. The COVID-19 epidemic poses several challenges for the ophthalmological community: to determine algorithms for timely diagnosis and treatment, as well as to ensure the prevention of complications from the organ of vision in patients who have undergone COVID-19. It may make sense to screen for coronaviruses in patients with inflammatory diseases of the posterior segment of the eye of unknown etiology. The inclusion of spectral optical coherence tomography with the function of angiography in a comprehensive examination of patients is important for the early detection of microcirculatory and morphometric changes in the optic disc, macular and peripapillary retina. It is advisable to use physiotherapeutic methods of treatment in patients with visual impairment in the post-COVID period, which will reduce the long-term drug load and increase the effectiveness of treatment.

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The Result of the Treatment of Optic Nerve Edema after COVID-19

Ioyleva,

Safonenko,

Otyrba

et al. 2023

Oftalʹmologiâ

Self Cite

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Ultrasound diagnostic criteria of anterior ischemic optic neuropathy and optic neuritis

Нероев

Киселева

Eliseeva

et al. 2023

Rossijskij oftalʹmologičeskij žurnal

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Purpose: to determine objective echographic criteria for the differential diagnosis of anterior ischemic optic neuropathy (AION) and optic neuritis (ON).Material and methods. The research involved 60 patients aged 40 to 60 years, including 30 patients with suspected AION and 30 patients with suspected ON. The control group consisted of 40 healthy volunteers. In addition to the standard ophthalmological examination, all patients underwent ultrasound optic nerve s examination with measurement of the optic nerve thickness and acoustic density (AD) of the parenchyma and optic nerve sheets. Assessment of blood flow in retrobulbar vessels was carried out in the modes of Color Doppler Imaging and pulse dopplerography.Results. There were no statistically significant differences in average echographic parameters of the optic nerve s thickness between the groups of patients with AION and ON. In patients with ON there was a statistically significant decrease in the average AD index compared to that in patients with AION and in healthy volunteers (106.02 ± 5.40 y. e., 146.58 ± 9.70 y.e. and 135.3 ± 2.1 y. e., accordingly). The AD values in all patients with AION exceeded 133 y. e., in patients with ON this index was less than 132 y. e. Evaluation of hemodynamic parameters in the vessels of the eye demonstrated a statistically significant decrease in the peak systolic velocity (Vsyst) and end-diastolic velocity (Vdiast) blood flow in the central retinal artery and medial and lateral short posterior ciliary arteries in patients with AION (in 2-fold) compared with ON and normal indices (p < 0.001). There were no statistically significant differences between parameters of blood flow in patients with ON and in healthy volunteers. In addition, there were no significant intergroup differences of hemodynamic parameters of the ophthalmic artery (p > 0.05).Conclusions. AD of the optic nerve and parameters of blood flow velocities (Vsyst and Vdiast) in medial and lateral short posterior ciliary arteries can be attributed to the diagnostic criteria of the AION and ON.

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Optical coherence tomography-angiography for anterior uveal tract evaluation in normal subjects and in pathology

Kiseleva,

Saakyan,

Makukhina

et al. 2023

Rossijskij oftalʹmologičeskij žurnal

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Purpose: to assess the potentials of optical coherence tomography-angiography (OCTA) in the evaluation of anterior segment (AS) uveal vessels in normal and pathological conditions.Material and methods. 20 healthy volunteers (40 eyes) with no ophthalmic pathology (the control group) and 85 previously untreated patients (85 eyes) with suspected tumors of the irido-ciliary area (the iris, the ciliary body and the peripheral sections of the choroid) were examined. All participants had optical coherence tomography (OCT) and OCTA of AS, with the qualitative assessment of scans (vessels pattern, lumen, tortuosity) and the quantitative assessment (vessel density index, VD%, for the affected zone). In ciliary body or choroid pathologies, VD index was measured for the conjunctiva in the focus projection. VD index included mean and local VD, as well as VD of perifocal tissues. In addition, B-mode ultrasound scanning and ultrasound biomicroscopy were performed.Results. OCTA scans in 4 sectors of the normal iris showed a predominantly radial pattern of conjunctival vessels positioning, with their lumen remaining the same along their entire visible length. The lowest VD value (38.5%) was registered in the temporal iris segment, while the highest (43.9%) was revealed in the inferior quadrant. In the iris tumors area, intrinsic vascularity molded in various vascular patterns was observed. Melanomas could be suspected because of the vessels oriented along the axis of the tumor and by non-uniform lumen of the vessels.Conclusion. AS-OCTA is an informative method for the visualization of iris vessels in normal conditions and in iris pathology and may be considered a valuable addition to the standard visualization techniques.

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Optical coherence tomography-angiography as a non-invasive method of pathology diagnosis of the microcirculatory bed of the optic nerve and macula

Abstract: The review discusses the development of optical coherence tomography with the function of angiography, focusing on its advantages, features, and prospects for the diagnosis of fundus pathologies.

Cited by 4 publications

References 43 publications

The Result of the Treatment of Optic Nerve Edema after COVID-19

The Result of the Treatment of Optic Nerve Edema after COVID-19

Ultrasound diagnostic criteria of anterior ischemic optic neuropathy and optic neuritis

Optical coherence tomography-angiography for anterior uveal tract evaluation in normal subjects and in pathology

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