Optical Coherence Tomography Angiography: Clinical Utility and Future Directions

Foulsham, William; Chien, Jason L; Lenis, Tamara L.; Papakostas, Thanos D.

doi:10.1177/24741264221080376

Cited by 6 publications

(4 citation statements)

References 105 publications

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“…The split-spectrum amplitude-decorrelation angiography algorithm was used to create OCT-A data. A detailed description of OCTA technology has been published elsewhere [19,20]. The essential principle is as follows, to put it briefly.…”

Section: Oct Angiographymentioning

confidence: 99%

Quantitative Analysis of Retinal Perfusion in Patients with Frontotemporal Dementia Using Optical Coherence Tomography Angiography

Esser,

Lahme,

Dierse

et al. 2024

Diagnostics

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Background: Optical coherence tomography angiography (OCT-A) provides detailed visualization of the perfusion of the vascular network of the eye. While in other forms of dementia, such as Alzheimer’s disease and mild cognitive impairment, reduced retinal perfusion was frequently reported, data of patients with frontotemporal dementia (FTD) are lacking. Objective: Retinal and optic nerve head perfusion was evaluated in patients with FTD with OCT-A. Quantitative OCT-A metrics were analyzed and correlated with clinical markers and vascular cerebral lesions in FTD patients. Methods: OCT-A was performed in 18 eyes of 18 patients with FTD and 18 eyes of 18 healthy participants using RTVue XR Avanti with AngioVue. In addition, patients underwent a detailed ophthalmological, neurological, and neuropsychological examination, cerebral magnetic resonance imaging (MRI), and lumbar puncture. Results: The flow density in the optic nerve head (ONH) and in the superficial capillary plexus (SCP) of the macula of patients was significantly lower compared to that of healthy controls (p < 0.001). Similarly, the VD in the deep capillary plexus (DCP) of the macula of patients was significantly lower compared to that of healthy controls (p < 0.001). There was no significant correlation between the flow density data, white matter lesions in brain MRI, cognitive deficits, and cerebrospinal fluid markers of dementia. Conclusions: Patients with FTD showed a reduced flow density in the ONH, and in the superficial and deep retinal capillary plexus of the macula, when compared with that of healthy controls. Quantitative analyses of retinal perfusion using OCT-A may therefore help in the diagnosis and monitoring of FTD. Larger and longitudinal studies are necessary to evaluate if OCT-A is a suitable biomarker for patients with FTD.

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Section: Oct Angiographymentioning

confidence: 99%

Quantitative Analysis of Retinal Perfusion in Patients with Frontotemporal Dementia Using Optical Coherence Tomography Angiography

Esser,

Lahme,

Dierse

et al. 2024

Diagnostics

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“…Various algorithms have been developed to optimize contrast signals and minimize noise, intensity‐based methods (e.g., split‐spectrum amplitude decorrelation angiography [SSADA]), encompassing phase‐based techniques, and complex‐based techniques (e.g., optical microangiography [OMAG]). Owing to its reliability, high image definition, and widespread accessibility, OCTA has found extensive application in evaluating posterior segment diseases, such as glaucoma, where ocular perfusion dysfunction is usually postulated as a pathophysiological mechanism [52, 53]. OCT constitutes a novel imaging modality for obtaining cross‐sectional images of biological tissues, grounded in the principles of low‐coherent light interference.…”

Section: The Development Of Fundus Imagingmentioning

confidence: 99%

Progress and challenges of in vivo flow cytometry and its applications in circulating cells of eyes

Lin,

Wang,

et al. 2024

Cytometry Pt A

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Circulating inflammatory cells in eyes have emerged as early indicators of numerous major diseases, yet the monitoring of these cells remains an underdeveloped field. In vivo flow cytometry (IVFC), a noninvasive technique, offers the promise of real‐time, dynamic quantification of circulating cells. However, IVFC has not seen extensive applications in the detection of circulating cells in eyes, possibly due to the eye's unique physiological structure and fundus imaging limitations. This study reviews the current research progress in retinal flow cytometry and other fundus examination techniques, such as adaptive optics, ultra‐widefield retinal imaging, multispectral imaging, and optical coherence tomography, to propose novel ideas for circulating cell monitoring.

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“…However, few automated algorithms have been developed to quantify morphological changes in these volumetric scans. A key challenge is accurately segmenting the capillaries, which have low contrast and discontinuity compared to major vessels in enface projections [13].…”

Section: Related Workmentioning

confidence: 99%

Arteriovenous Length Ratio: A Novel Method for Evaluating Retinal Vasculature Morphology and Its Diagnostic Potential in Eye-Related Diseases

Badawi,

Takruri,

Al-Hattab

et al. 2023

J. Imaging

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Retinal imaging is a non-invasive technique used to scan the back of the eye, enabling the extraction of potential biomarkers like the artery and vein ratio (AVR). This ratio is known for its association with various diseases, such as hypertensive retinopathy (HR) or diabetic retinopathy, and is crucial in assessing retinal health. HR refers to the morphological changes in retinal vessels caused by persistent high blood pressure. Timely identification of these alterations is crucial for preventing blindness and reducing the risk of stroke-related fatalities. The main objective of this paper is to propose a new method for assessing one of the morphological changes in the fundus through morphometric analysis of retinal images. The proposed method in this paper introduces a novel approach called the arteriovenous length ratio (AVLR), which has not been utilized in previous studies. Unlike commonly used measures such as the arteriovenous width ratio or tortuosity, AVLR focuses on assessing the relative length of arteries and veins in the retinal vasculature. The initial step involves segmenting the retinal blood vessels and distinguishing between arteries and veins; AVLR is calculated based on artery and vein caliber measurements for both eyes. Nine equations are used, and the length of both arteries and veins is measured in the region of interest (ROI) covering the optic disc for each eye. Using the AV-Classification dataset, the efficiency of the iterative AVLR assessment is evalutaed. The results show that the proposed approach performs better than the existing methods. By introducing AVLR as a diagnostic feature, this paper contributes to advancing retinal imaging analysis. It provides a valuable tool for the timely diagnosis of HR and other eye-related conditions and represents a novel diagnostic-feature-based method that can be integrated to serve as a clinical decision support system.

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Optical Coherence Tomography Angiography: Clinical Utility and Future Directions

Cited by 6 publications

References 105 publications

Quantitative Analysis of Retinal Perfusion in Patients with Frontotemporal Dementia Using Optical Coherence Tomography Angiography

Quantitative Analysis of Retinal Perfusion in Patients with Frontotemporal Dementia Using Optical Coherence Tomography Angiography

Progress and challenges of in vivo flow cytometry and its applications in circulating cells of eyes

Arteriovenous Length Ratio: A Novel Method for Evaluating Retinal Vasculature Morphology and Its Diagnostic Potential in Eye-Related Diseases

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