Optical Coherence Tomography Angiography Findings in Optic Nerve Sheath Meningioma

Interlandi, Emanuela; Pellegrini, F.; Papayannis, Alessandro; Cuna, Alessandra; Mandarà, Erika; Luca, Marco De; Cirone, Daniele; Ciabattoni, Cristina; Marullo, Michele

doi:10.1159/000508411

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…OCTA detects particle (blood cell) movement that can be used to construct microvascular density maps [ 7 , 8 ]. A number of reports indicate that there is decreased optic disc perfusion and peripapillary capillary density on OCTA in patients with chronic glaucoma [ 9 , 10 , 11 ] and other optic neuropathies [ 12 , 13 , 14 , 15 , 16 ]. Chen et al [ 12 ] demonstrated RNFL thinning and decrease in the peripapillary capillary density on OCTA in various optic neuropathies.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography Angiography in Chiasmitis

Cuna¹,

Pellegrini

Interlandi³

et al. 2022

Case Rep Ophthalmol

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A 29-year-old girl presented complaining of acute bilateral visual loss associated with mild headache and retrobulbar pain. She was diagnosed with chiasmal optic neuritis caused by multiple sclerosis. Her visual acuity and visual field defect promptly improved after steroid therapy. However optical coherence tomography angiography showed a progressive reduction of superficial capillary plexus density of the retina and optic nerve consistent with the progressive impairment of the retinal ganglionar cell layer. Contrary to chiasmal compression, in chiasmal optic neuritis, the superficial capillary plexus density reduction is diffuse and does not reflect the peculiar anatomy of the chiasm.

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Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography Angiography in Chiasmitis

Cuna¹,

Pellegrini

Interlandi³

et al. 2022

Case Rep Ophthalmol

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“…Thus, the works of Miller [ 6 ] and Douglas et al [ 7 ] establish a relationship between ONSM and optic atrophy, but do not analyze the damage pattern more precisely. Interlandi et al reported [ 8 ] on a reduction of temporal RNFL thickness in a single-case report of ONSM.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of peripapillary retinal nerve fiber layer atrophy in glaucoma, optic nerve sheath meningioma, and sphenoid wing meningioma

Tonagel¹,

Wilhelm²,

Kelbsch³

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Background/objectives The correct classification of a slowly progressing optic atrophy can be challenging. The aim of this work was to find out if the characteristics of peripapillary retinal nerve fiber layer (RNFL) thickness loss differ between open angle glaucoma (POAG), optic nerve sheath meningioma (ONSM), and sphenoid wing meningioma (SWM). Methods A total of 45 patients with POAG, ONSM, and SWM were included in the retrospective study. The peripapillary RNFL thickness measured by spectral-domain optical coherence tomography was analyzed using the Heidelberg Engineering glaucoma module©. Results Each group consisted of 15 patients. The temporal sector of the RNFL thickness showed a median decrease of − 17 µm in glaucoma patients (range + 6/–34 µm), − 43 µm in ONSM (range − 19/ − 52 µm), and − 44 µm in SWM patients (range − 25/ − 52 µm). The RNFL thickness of the temporal sector of glaucoma patients differed significantly from the other groups (p < 0.001). All other sectors showed no significant difference between the 3 groups. Conclusion The peripapillary RNFL thickness of the temporal sector of patients with beginning to moderate POAG is usually inside normal limits or borderline. In contrast, patients with ONSM and SWM are much more likely to show a considerable reduction in RNFL thickness of the temporal sector. RNFL thickness of the temporal sector marked outside normal limits occurred exclusively in meningioma patients. Considering the presence of this condition as a predictor for meningioma, sensitivity and specificity were 0.8 and 1.0, respectively. In patients with significant reduction in RNFL thickness of the temporal sector, magnetic resonance imaging of the head should be considered to rule out compression of the optic nerves.

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“…We do not have a clear explanation for the excellent visual outcome obtained in the present case. Although there is no good standard for pretreatment evaluation for prognosis of visual function [17][18][19], good pretreatment vision is reported to be a reasonable prognostic factor for good visual outcomes [8,9]. Moreover, a good appearance of the retinal nerve fiber layer on OCT is usually considered a sign of good potential recovery [18].…”

Section: Discussionmentioning

confidence: 99%

Salvage Radiosurgery for Optic Nerve Sheath Meningioma

Vakharia¹,

Hasegawa²,

Stafford

et al. 2021

Cureus

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Optic nerve sheath meningiomas (ONSMs) are rare and benign tumors that affect the optic nerve. Although surgical decompression may be used for large tumors that cause mass effect on the surrounding structures, the mainstay of treatment is radiotherapy. We report the case of a 54-year-old female patient who presented with progressive vision loss due to a recurrent right ONSM despite fractionated radiotherapy eight years prior and the subsequent interval regression of the tumor. The optical coherence tomography at the time of recurrence revealed thinning of the right retinal nerve fiber layer. She underwent salvage stereotactic radiosurgery using a marginal dose of 15 Gy. At six months post-radiosurgery, the patient had a dramatic improvement in visual acuity and visual fields despite persistent thinning of the retinal nerve fiber layer. This case illustrates how salvage radiosurgery can be a useful treatment modality in these challenging situations. This tumor's exophytic growth and the steep dose fall-off of Gamma Knife radiosurgery might favorably affect visual recovery. However, the outcomes of single-session radiosurgery for ONSMs should be further evaluated.

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Optical Coherence Tomography Angiography Findings in Optic Nerve Sheath Meningioma

Cited by 4 publications

References 9 publications

Optical Coherence Tomography Angiography in Chiasmitis

Optical Coherence Tomography Angiography in Chiasmitis

Characteristics of peripapillary retinal nerve fiber layer atrophy in glaucoma, optic nerve sheath meningioma, and sphenoid wing meningioma

Salvage Radiosurgery for Optic Nerve Sheath Meningioma

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