Optical coherence tomography angiography measurements in Parkinson’s disease: A systematic review and meta-analysis

Salehi, Mohammad Amin; Rezagholi, Fateme; Mohammadi, Soheil; Zakavi, Seyed Sina; Jahanshahi, Ali; Gouravani, Mahdi; Yazdanpanah, Ghasem; Seddon, Ian; Jabbehdari, Sayena; Singh, Rishi P.

doi:10.1038/s41433-023-02483-2

Cited by 10 publications

(5 citation statements)

References 60 publications

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“…Furthermore, in a recent systematic review and meta-analysis of 925 PD eyes in comparison with 1501 control eyes, no significant differences in the SCP vessel density of whole, parafoveal, and perifoveal regions, and DCP density were shown. 58 Moreover, SCP and DCP densities were not different between patients and controls in a study of HD. 41 These findings may highlight vascular pathogenesis in some neurodegeneration disorders in comparison with others.…”

Section: Discussionmentioning

confidence: 89%

“…The SCP density was correlated with the GCL thickness and peripapillary NFL thickness, similar to our study on NBIA. Furthermore, in a recent systematic review and meta‐analysis of 925 PD eyes in comparison with 1501 control eyes, no significant differences in the SCP vessel density of whole, parafoveal, and perifoveal regions, and DCP density were shown 58 . Moreover, SCP and DCP densities were not different between patients and controls in a study of HD 41 .…”

Section: Discussionmentioning

confidence: 92%

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Neurodegeneration with Brain Iron Accumulation Disorders and Retinal Neurovascular Structure

Amini,

Rohani,

Fasano

et al. 2023

Movement Disorders

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BackgroundThe unique neurovascular structure of the retina has provided an opportunity to observe brain pathology in many neurological disorders. However, such studies on neurodegeneration with brain iron accumulation (NBIA) disorders are lacking.ObjectivesTo investigate NBIA's neurological and ophthalmological manifestations.MethodsThis cross‐sectional study was conducted on genetically confirmed NBIA patients and an age‐gender‐matched control group. The thickness of retinal layers, central choroidal thickness (CCT), and capillary plexus densities were measured by spectral domain‐optical coherence tomography (SD‐OCT) and OCT angiography, respectively. The patients also underwent funduscopy, electroretinography (ERG), visual evoked potential (VEP), and neurological examination (Pantothenate‐Kinase Associated Neurodegeneration‐Disease Rating Scale [PKAN‐DRS]). The generalized estimating equation model was used to consider inter‐eye correlations.ResultsSeventy‐four patients' and 80 controls' eyes were analyzed. Patients had significantly decreased visual acuity, reduced inner or outer sectors of almost all evaluated layers, increased CCT, and decreased vessel densities, with abnormal VEP and ERG in 32.4% and 45.9%, respectively. There were correlations between visual acuity and temporal peripapillary nerve fiber layer (positive) and between PKAN‐DRS score and disease duration (negative), and scotopic b‐wave amplitudes (positive). When considering only the PKAN eyes, ONL was among the significantly decreased retinal layers, with no differences in retinal vessel densities. Evidence of pachychoroid was only seen in patients with Kufor Rakeb syndrome.ConclusionObserving pathologic structural and functional neurovascular changes in NBIA patients may provide an opportunity to elucidate the underlying mechanisms and differential retinal biomarkers in NBIA subtypes in further investigations. © 2023 International Parkinson and Movement Disorder Society.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 92%

Neurodegeneration with Brain Iron Accumulation Disorders and Retinal Neurovascular Structure

Amini,

Rohani,

Fasano

et al. 2023

Movement Disorders

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“…Moreover, misfolded and phosphorylated alpha-synuclein deposits have been identified in retinal tissues, possibly contributing to visual impairment. 14…”

Section: Dopamine's Role In Visionmentioning

confidence: 99%

Through the eyes of Parkinson\'s: A narrative review of clinical spectrum and ophthalmological challenges in Parkinson’s disease

Doke,

Sonawane,

Thorat

et al. 2023

IJCEO

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The ophthalmic non-motor dysfunctions are most common among individuals with Parkinson’s disease, manifesting both prior to motor symptoms and throughout the progression of the neurodegenerative condition. Detecting these impairments early on holds significant potential for disease identification, particularly in its nascent stages. Given the comprehensive nature of ocular involvement, encompassing both extraocular and intraocular elements of the visual system, a comprehensive evaluation stands to benefit patients. Considering the shared embryonic origin of the retina and central nervous system, exploring retinal changes in Parkinson's disease could yield insights applicable to the broader brain context. Consequently, identifying these manifestations could enhance medical assessments of Parkinson's disease and offer predictive value regarding its progression.The impact of these ophthalmological issues extends to the quality of life of Parkinson's disease patients, accentuating the importance of addressing them. This review presents a comprehensive overview of the primary visual impairments linked to Parkinson's disease, reflecting a substantial portion of the visual challenges encountered by affected individuals and for the overall well-being of those living with the condition.

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“…It must be noted that many of the imaging biomarkers discussed above are not specific to various forms of cardiovascular disease. For instance, many forms of dementia, such as Alzheimer's and Parkinson's Disease, have been associated with reduced vessel density in various layers of the retina when examined with OCTA [114][115][116]. Furthermore, parameters such as reduced vessel density in the various vascular layers of the retina are associated with multiple disease states of interest, such as chronic CVD (including hypertension and diabetes) and also acute stroke or MI risk.…”

Section: Limitationsmentioning

confidence: 99%

Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques

Colcombe,

Mundae,

Kaiser

et al. 2023

JPM

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Many retinal diseases and imaging findings have pathophysiologic underpinnings in the function of the cardiovascular system. Myriad retinal conditions, new imaging biomarkers, and novel image analysis techniques have been investigated for their association with future cardiovascular risk or utility in cardiovascular risk prognostication. An intensive literature search was performed to identify relevant articles indexed in PubMed, Scopus, and Google Scholar for a targeted narrative review. This review investigates the literature on specific retinal disease states, such as retinal arterial and venous occlusions and cotton wool spots, that portend significantly increased risk of future cardiovascular events, such as stroke or myocardial infarction, and the implications for personalized patient counseling. Furthermore, conditions diagnosed primarily through retinal bioimaging, such as paracentral acute middle maculopathy and the newly discovered entity known as a retinal ischemic perivascular lesion, may be associated with future incident cardiovascular morbidity and are also discussed. As ever-more-sophisticated imaging biomarkers and analysis techniques are developed, the review concludes with a focused analysis of optical coherence tomography and optical coherence tomography angiography biomarkers under investigation for potential value in prognostication and personalized therapy in cardiovascular disease.

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Optical coherence tomography angiography measurements in Parkinson’s disease: A systematic review and meta-analysis

Cited by 10 publications

References 60 publications

Neurodegeneration with Brain Iron Accumulation Disorders and Retinal Neurovascular Structure

Neurodegeneration with Brain Iron Accumulation Disorders and Retinal Neurovascular Structure

Through the eyes of Parkinson\'s: A narrative review of clinical spectrum and ophthalmological challenges in Parkinson’s disease

Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques

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