Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker

“…The persistence of axonal swelling, which most probably relates to a stasis of organellar transport, resolves at a slower rate. Lacking a longitudinal follow‐up at the crucial transition from pre‐clinical to conversion, we can only speculate on what triggers conversion and we cannot exclude that the VD reduction is only a consequence of optic nerve atrophy, similarly to other chronic optic neuropathy . However, one hypothesis to explain the catastrophic rapidity of disease onset, which occurs in days to weeks may implicate some anatomical considerations.…”

“…OCT‐A scans of the optic disc and the paripapillary region were obtained by spectral domain OCT system, as already documented …”

“…Using the split‐spectrum amplitude‐decorrelation angiography (SSADA) algorithm, vascular perfusion can be quantified . OCT‐A has been used to detect microvasculature reduction in other optic neuropathies . To date, only single case reports have qualitatively described microvascular changes in LHON detected by OCT‐A …”

OCTA in neurodegenerative optic neuropathies: emerging biomarkers at the eye–brain interface

“…Using OCTA, Balducci and colleagues found that the temporal networks of the peripapillary and optic nerve head microvasculature were reduced in DOA patients, which is consistent with the preferential involvement of the PMB that similarly is a hallmark feature in LHON. 92,93 Intriguingly, Balducci and colleagues also showed that radial peripapillary capillary vessel density strongly correlated with both functional and structural parameters including best-corrected visual acuity, visual field testing, and RNFL thickness. These findings suggest that perfusion indices may potentially be useful for staging and monitoring the natural history of DOA.…”

“…These findings suggest that perfusion indices may potentially be useful for staging and monitoring the natural history of DOA. 92 Further studies conducted by Martins and colleagues evaluated the macular microvascular blood supply and the link between structural and vascular changes in DOA using OCTA. 94 Their analysis of the ratio between parafoveal SCP vessel density and macular ganglion cell complex thickness showed more severe relative vascular pathology.…”