Optical Coherence Tomography Angiography of Retinal Venous Occlusion

Kashani, Amir H; Lee, Sun Young; Moshfeghi, Andrew A; Durbin, Mary K; Puliafito, Carmen A.

doi:10.1097/iae.0000000000000811

Cited by 154 publications

(135 citation statements)

References 9 publications

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“…in OCTA of 26 eyes with RVO that were consistent with clinical, anatomic, and fluorescein angiographic findings including areas of impaired vascular perfusion, retinal atrophy, vascular dilation, shunt vessels, and some forms of intraretinal edema [97] . Researchers also demonstrated the usefulness of OCTA in evaluating the response to anti-VEGF treatment [98,99] .…”

Section: For Retinal Vein Occlusions(rvo) Kashani Et Al Reported Finsupporting

confidence: 68%

New Frontiers in Retinal Imaging

Liu

Paulus

2016

International Journal of Ophthalmic Research

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Ophthalmology is one of the most technology-driven medical specialties with numerous recent advances due to improvements in imaging technology. Advances in retinal imaging have allowed for better understanding of the eye in health and disease, retinal pathophysiology, documenting of disease progression,and assessing therapeutic response. During the last 50 years, both the hardware such as lasers in addition to software image analysis have significantly evolved. These improvements have included facilitating the progress of the ocular examination, reducing the discomfort of patients, and obtaining high quality non-invasive images. This article will review the classic retinal imaging modalities, state-of-the-art retinal imaging technologies, and an introduction of emerging imaging technologies.

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Section: For Retinal Vein Occlusions(rvo) Kashani Et Al Reported Finsupporting

confidence: 68%

New Frontiers in Retinal Imaging

Liu

Paulus

2016

International Journal of Ophthalmic Research

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“…1 Recent investigations using OCTA have been mainly focused on showcasing its applications in visualizing the flow characteristics of microvascular diseases within the macula, such as age-related macular degeneration (AMD) 2 and diabetic retinopathy (DR), 3,4 the two leading causes of blindness worldwide. 5,6 In addition, OCTA has documented microvascular abnormalities in other macular diseases such as branch retinal vein occlusion (BRVO), central retinal vein occlusion, 7 and macular telangiectasia type 2 (MacTel2). 8 Compared with conventional dye-based angiography, OCTA offers a safer, faster, and more cost effective alternative for ocular imaging of the macular vasculature.…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography

et al. 2016

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“…8, 16, 17 SD-OCTA allows both qualitative and quantitative assessment of microvascular integrity in retinal vascular diseases, particularly in the parafovea where the most visually-significant pathology is often present (e.g. macular edema).…”

Section: Introductionmentioning

confidence: 99%

Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography

Kim

Rodger

Shahidzadeh

et al. 2016

American Journal of Ophthalmology

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159

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Purpose To quantify retinal capillary density and morphology in uveitis using SD-OCTA. Design Cross-sectional, observational study Methods Healthy and uveitic subjects were recruited from two tertiary care eye centers. Prototype SD-OCTA devices (Cirrus, Carl Zeiss Meditec, Inc., Dublin, CA) were used to generate 3×3 mm2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity-and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and non-segmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. A P value < 0.05 was accepted as significant. Reproducibility and repeatability were assessed using the Intraclass Correlation Coefficient (ICC). Results The SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared to healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis. Conclusions Quantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.

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Optical Coherence Tomography Angiography of Retinal Venous Occlusion

Cited by 154 publications

References 9 publications

New Frontiers in Retinal Imaging

New Frontiers in Retinal Imaging

Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography

Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography

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