Optical Coherence Tomography as a Tool for In Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study of Diagnostic Accuracy

Bus, Mieke T. J.; Bruin, Daniël M. de; Faber, Dirk J.; Kamphuis, Guido; Zondervan, Patricia J.; Laguna-Pes, M.P.; Leeuwen, Ton G. van; Reijke, T.M. De; Rosette, Jean J.M.C.H. de la

doi:10.1016/j.juro.2016.04.117

Cited by 42 publications

(44 citation statements)

References 17 publications

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“…Owing to the improved definitions for the sensitivity roll-off and confocal point spread function in the newly developed software, the m OCT values for low-grade and high-grade UTUC were substantially higher in the present study. The corresponding sensitivity (83%) and specificity (94%) were similar to the sensitivity (87%) and specificity (90%) of the study by Bus et al [15].…”

Section: Discussionsupporting

confidence: 85%

“…Besides technical improvements, the sample size in the present study was substantially larger than in the previous study that proposed a μ OCT cut‐off value . Increasing the sample size of this post‐hoc analysis was achieved by additional inclusion of patients in whom only the histopathologic grade from ureterorenoscopic biopsies was available for comparison.…”

Section: Discussionmentioning

confidence: 92%

“…For this post‐hoc analysis, OCT data was obtained from the study by Bus et al . The study was approved by the institutional review board and was registered on http://Clinicaltrials.gov (NCT02326909).…”

Section: Methodsmentioning

confidence: 99%

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Grading upper tract urothelial carcinoma with the attenuation coefficient of in‐vivo optical coherence tomography

et al. 2019

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Introduction With catheter based optical coherence tomography (OCT), high resolution images of the upper urinary tract can be obtained, thereby facilitating the detection of upper tract urothelial carcinomas (UTUC). We hypothesized that the attenuation coefficient of the OCT signal (μOCT) is related to the histopathologic grade of the tumor. Objectives In this study, we aimed to define the μOCT cut‐off for discriminating high grade and low grade papillary UTUC. Methods For this post‐hoc analysis, data from OCT imaging of papillary UTUC was obtained from patients during ureterorenoscopy. OCT images and raw data were simultaneously analyzed with in‐house developed software. The μOCT determined in papillary UTUCs and corresponding histopathologic grading from either biopsies or radical resection specimens were compared. Results Thirty‐five papillary UTUC from 35 patients were included. μOCT analysis was feasible in all cases. The median μOCT was 3.3 mm−1 (IQR 2.7–3.7 mm−1) for low‐grade UTUC and 4.9 mm−1 (IQR 4.3–6.1 mm−1) for high‐grade UTUC (P = 0.004). ROC analysis yielded a μOCT cut‐off value of >4.0 mm−1 (AUC = 0.85, P < 0.001) with a sensitivity of 83% and a specificity of 94% for high‐grade papillary UTUC. Conclusions This study proposes a μOCT cut‐off of 4.0 mm−1 for quantitative grading of UTUC with ureterorenoscopic OCT imaging. The promising diagnostic accuracy calculations justify further studies to validate the proposed cut‐off value. Implementation of the software for the μOCT analysis in OCT systems may allow for μOCT assessment at real time during ureterorenoscopy. Lasers Surg. Med. 51:399–406, 2019. © 2019 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 92%

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Grading upper tract urothelial carcinoma with the attenuation coefficient of in‐vivo optical coherence tomography

et al. 2019

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“…A follow-on study on a large number of patients (n ¼ 26) by Bus et al further validated the higher attenuation of high-grade lesions (median μ OCT : 3.0 mm −1 ) than low-grade lesions (median μ OCT : 2.1 mm −1 ), demonstrating the feasibility of OCT attenuation for grading low-and high-grade lesions. 88 A recent study on 35 patients by Freund et al 89 demonstrated a consistent contrast in OCT attenuation, as summarized in Table 3.…”

Section: Oncologymentioning

confidence: 82%

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

et al. 2020

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Significance: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT attenuation coefficient and developing them toward clinical applications. Aim: Our review provides an overview of the main models and methods, their assumptions and applicability, together with a survey of preclinical and clinical demonstrations and their translation potential. Results: The use of the attenuation coefficient, particularly when presented in the form of parametric en face images, is shown to be applicable in various medical fields. Most studies show the promise of the OCT attenuation coefficient in differentiating between tissues of clinical interest but vary widely in approach. Conclusions: As a future step, a consensus on the model and method used for the determination of the attenuation coefficient is an important precursor to large-scale studies. With our review, we hope to provide a basis for discussion toward establishing this consensus.

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“…25). In a larger study, the sensitivity and specificity of OCT for staging urethral tumors was 86.7% and 78.6% respectively and for grading, 91.7% and 78.6%, respectively [178].…”

Section: Urinary Tractmentioning

confidence: 88%

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Gora¹,

Suter²,

Tearney³

et al. 2017

Biomed. Opt. Express

262

203

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Abstract:In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forwardviewing probes, along with different scanning mechanisms (proximal-scanning versus distalscanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. References and links 1. T. Cao and H. L. Tey, "High-definition optical coherence tomography -an aid to clinical practice and research in dermatology," J. Dtsch. Dermatol. Ges. 13(9), 886-890 (2015). 2. J. Olsen, L. Themstrup, and G. B. Jemec, "Optical coherence tomography in dermatology," G. Ital. Dermatol.Venereol. 150(5), 603-615 (2015). 3. M. Ulrich, L. Themstrup, N. de Carvalho, M. Manfredi, C. Grana, S. Ciardo, R. Kästle, J. Holmes, R.Whitehead, G. B. Jemec, G. Pellacani, and J. Welzel, "Dynamic Optical Coherence Tomography in Dermatology," Dermatology (Basel) 232(3), 298-311 (2016). 4. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21(7), 543-545 (1996). 5. A. M. Rollins, R. Ung-Arunyawee, A. Chak, R. C. K. Wong, K. Kobayashi, M. V. Sivak, Jr., and J. A. Izatt, "Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design," Opt. Lett. 24(19), 1358-1360 (1999). 6. M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A.Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51(4), 474-479 (2000). 7. J. Xi, A. Zhang, Z. Liu, W. Liang, L. Y. Lin, S. Yu, and X. Li, "Diffractive catheter for ultrahigh-resolution spectral-domain volumetric OCT imaging," Opt. Lett. 39(7), 2016-2019 (2014). 8. P. H. Tran, D. S. Mukai, M. Brenner, and Z. Chen, "In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe," Opt. Lett. 29(11), 1236-1238 (2004). Goodnow, and C. Petersen, "Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography," Opt. Lett. 29(19), 2261-2263 (2004). 10. T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H.Mashimo, A. E. Cable, and J. G. Fujimoto, "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology," Biomed. Opt. Express 4(7), 1119-11...

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Optical Coherence Tomography as a Tool for In Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study of Diagnostic Accuracy

Cited by 42 publications

References 17 publications

Grading upper tract urothelial carcinoma with the attenuation coefficient of in‐vivo optical coherence tomography

Grading upper tract urothelial carcinoma with the attenuation coefficient of in‐vivo optical coherence tomography

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

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