Optical Coherence Tomography for the Detection of Remote Optic Neuritis in Multiple Sclerosis

Xu, Lucy; Bermel, Robert; Nowacki, Amy S.

doi:10.1111/jon.12326

Cited by 12 publications

(5 citation statements)

References 30 publications

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“…These findings suggest that the papillomacular bundle is preserved in SCA10 and that RNFL thinning is not caused by a loss of cells in the GCL, corroborating the conclusions reported by Alvarez et al 21 . They also suggest that retinal degeneration in SCA3 is similar to the degeneration that occurs in multiple sclerosis 23 but different from the degeneration in idiopathic Parkinson's disease, in which although the RNFL becomes thinner as the patient's clinical condition worsens, it is accompanied by neuron loss in the GCL 24,25 , and also different from the degeneration in Alzheimer's disease, where there is mainly loss of neurons in the GCL 26,27. It is also different from the pattern found in SCA1, where there is more neuronal loss in the temporal region, suggesting that the papillomacular bundle is affected 28 .…”

Section: Discussionmentioning

confidence: 95%

A Comparative Optical Coherence Tomography Study of Spinocerebellar Ataxia Types 3 and 10

et al. 2017

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SCA3 presents with a CAG expansion at 14q24.3-q32 while SCA10 shows an ATTCT expansion at 22q13-qter. SCA10 seems to be less aggressive than SCA3. For an in vivo, noninvasive approach of the correlation between central nervous system and clinical evolution, we can use optic coherence tomography (OCT) to measure retinal nerve fiber (RNFL) and ganglion cell layer (GCL) thickness. To describe OCT findings in SCA10, correlate it with expansion size and disease severity and compare with those of SCA3. We analyzed ten individuals with SCA3 and nine with SCA10 recruited from the neurology service of Hospital de Clínicas of Paraná-Brazil. They were submitted to OCT and clinical evaluation using SARA score. Expansion size, demographic data, time from disease onset, and age of onset were collected. We found no correlation between size of expansion, SARA, and RNFL or GCL thickness in SCA10. RNFL seemed to be thicker in SCA10 (p > 0.05). GCL thickness, SARA, median age, and time from disease onset did not differ between groups. SCA10 individuals had an earlier disease onset. In SCA3, there was a negative correlation between SARA and RNFL thickness in nasal area. To the best of our knowledge, this is the first paper assessing retinal changes by OCT in individuals with SCA10. The lack of correlation between disease progression, age, and time since onset supports the anatomopathological findings which suggest SCA10 is less aggressive than other SCAs. The findings in SCA3 are in accordance with the literature.

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Section: Discussionmentioning

confidence: 95%

A Comparative Optical Coherence Tomography Study of Spinocerebellar Ataxia Types 3 and 10

et al. 2017

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“…PMB thickness remains of uncertain clinical significance. One study of MS patients reported PMB thickness as the best model to discriminate between remote ON and non-ON eyes, 13 whereas another demonstrated that adding PMB measurements to OCT does not increase sensitivity to detect remote ON. 14 Interestingly, our median PMB thickness (27 µm) was lower than previously published data in MS-ON (mean = 35–40 µm).…”

Section: Discussionmentioning

confidence: 99%

“…As seen in Table 1, 8 cases were included in the analysis (3 female, 5 male). Median age at disease onset was 13 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) years. All patients had a MOG titer of 1:100-1:1,000 and had ON as determined by inclusion criteria.…”

Section: Patient Characteristicsmentioning

confidence: 99%

Myelin Oligodendrocyte Glycoprotein Antibody Disease Optic Neuritis: A Structure–Function Paradox?

Ross,

Kenney,

Balcer

et al. 2024

Journal of Neuro-Ophthalmology

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Background: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a demyelinating disorder that most commonly presents with optic neuritis (ON) and affects children more often than adults. We report 8 pediatric patients with MOG-associated ON and characterize focal optical coherence tomography (OCT) abnormalities over time that help distinguish this condition from the trajectories of other demyelinating disorders. These OCT findings are examined in the context of longitudinal visual function testing. Methods: This is a retrospective case series of 8 pediatric patients with MOG-associated ON who were referred for neuro-ophthalmic evaluation. Longitudinal data for demographics, clinical history, physical examination, and OCT obtained in the course of clinical evaluations were collected through retrospective medical record review. Results: Patients demonstrated acute peripapillary retinal nerve fiber layer (RNFL) thickening in one or both eyes, consistent with optic disc swelling. This was followed by steady patterns of average RNFL thinning, with 9 of 16 eyes reaching significantly low RNFL thickness using OCT platform reference databases (P < 0.01), accompanied by paradoxical recovery of high-contrast visual acuity (HCVA) in every patient. There was no correlation between HCVA and any OCT measures, although contrast sensitivity (CS) was associated with global thickness, PMB thickness, and nasal/temporal (N/T) ratio, and color vision was associated with PMB thickness. There was a lower global and papillomacular bundle (PMB) thickness (P < 0.01) in clinically affected eyes compared with unaffected eyes. There was also a significantly higher N:T ratio in clinically affected eyes compared with unaffected eyes in the acute MOG-ON setting (P = 0.03), but not in the long-term setting. Conclusions: MOG shows a pattern of prominent retinal atrophy, as demonstrated by global RNFL thinning, with remarkable preservation of HCVA but remaining deficits in CS and color vision. These tests may be better clinical markers of vision changes secondary to MOG-ON. Of the OCT parameters measured, PMB thickness demonstrated the most consistent correlation between structural and functional measures. Thus, it may be a more sensitive marker of clinically significant retinal atrophy in MOG-ON. The N:T ratio in acute clinically affected MOG-ON eyes in our study was higher than the N:T ratio of neuromyelitis optica (NMO)-ON eyes and similar to the N:T ratio in multiple sclerosis (MS)-ON eyes as presented in the prior literature. Therefore, MOG may share a more similar pathophysiology to MS compared with NMO.

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“…172 RNFL thickness is reduced in ON and MS patients compared with healthy controls (Figure 2). This is seen using OCT in eyes with prior ON, 171,[173][174][175][176][177][178][179][180][181][182][183][184][185][186][187] particularly temporally and inferiorly. 176,177,188 The majority of studies also identified reduced pRNFL thickness in MS patients without prior history of ON (MS-NON), although to a lesser extent.…”

Section: Oct In Multiple Sclerosismentioning

confidence: 92%

Retinal correlates of neurological disorders

Yap

Si²,

et al. 2019

Therapeutic Advances in Chronic Disease

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Considering the retina as an extension of the brain provides a platform from which to study diseases of the nervous system. Taking advantage of the clear optical media of the eye and ever-increasing resolution of modern imaging techniques, retinal morphology can now be visualized at a cellular level in vivo. This has provided a multitude of possible biomarkers and investigative surrogates that may be used to identify, monitor and study diseases until now limited to the brain. In many neurodegenerative conditions, early diagnosis is often very challenging due to the lack of tests with high sensitivity and specificity, but, once made, opens the door to patients accessing the correct treatment that can potentially improve functional outcomes. Using retinal biomarkers in vivo as an additional diagnostic tool may help overcome the need for invasive tests and histological specimens, and offers the opportunity to longitudinally monitor individuals over time. This review aims to summarise retinal biomarkers associated with a range of neurological conditions including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and prion diseases from a clinical perspective. By comparing their similarities and differences according to primary pathological processes, we hope to show how retinal correlates can aid clinical decisions, and accelerate the study of this rapidly developing area of research.

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Optical Coherence Tomography for the Detection of Remote Optic Neuritis in Multiple Sclerosis

Cited by 12 publications

References 30 publications

A Comparative Optical Coherence Tomography Study of Spinocerebellar Ataxia Types 3 and 10

A Comparative Optical Coherence Tomography Study of Spinocerebellar Ataxia Types 3 and 10

Myelin Oligodendrocyte Glycoprotein Antibody Disease Optic Neuritis: A Structure–Function Paradox?

Retinal correlates of neurological disorders

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