Optical coherence tomography images simulated with an analytical solution of Maxwell’s equations for cylinder scattering

Brenner, Thomas; Reitzle, Dominik; Kienle, Alwin

doi:10.1117/1.jbo.21.4.045001

Cited by 19 publications

(33 citation statements)

References 45 publications

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“…The method proposed in Section 2 can be applied to calculate the scattered field by a target in those applications where broadband light is used [9], [7]. The scattering problem is solved first for an incident pulsed plane wave, and this will be used as the reference case.…”

Section: Numerical Results For a Pulsed Gaussian Beammentioning

confidence: 99%

“…In the field of OCT imaging, many approaches have been proposed. [3]- [9]. In [6], a Monte Carlo model is applied to the angiographic OCT imaging of small vessels in microvascular networks.…”

Section: Introductionmentioning

confidence: 99%

“…An analytical solution for OCT applications is given in [9] for the case of a cylinder in free space, and time-domain analyses are proposed for plane-wave and Gaussian beam sources.…”

Section: Introductionmentioning

confidence: 99%

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Full-wave analysis of the scattering of a pulsed light beam by dielectric cylinders embedded in a homogeneous medium

Ponti¹,

Santarsiero²,

Schettini³

2019

J. Opt.

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An approach to study the time-domain scattering by a set of dielectric cylinders with circular cross section, placed in a semi-infinite medium, is presented. The illuminating light comes from a pulsed beam impinging onto the cylinders from outside the medium. The solution is developed in a semi-analytical way, starting from results based on the Cylindrical Wave Approach pertinent to the case of illumination by a monochromatic plane wave. The method is numerically implemented to simulate the scattering response of buried cylinders illuminated by a pulsed Gaussian beam. In the presented results, the different contributions to the total scattered field are recognizable, giving account of all the interactions between incident field, target and interface. The model adopted is well suited to the study, at optical frequencies, of scattering problems involving biological samples, such as vessels and fibers, embedded in tissues or immersed in fluids, through fast and accurate electromagnetic simulation.

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Section: Numerical Results For a Pulsed Gaussian Beammentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Full-wave analysis of the scattering of a pulsed light beam by dielectric cylinders embedded in a homogeneous medium

Ponti¹,

Santarsiero²,

Schettini³

2019

J. Opt.

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“…58 Efficiency improvements can be achieved by precomputing scatterer microstructure, 65 and by using analytical solutions of Maxwell's equations for specific shapes, such as scattering from cylinders. 66,67 These models remain challenging to implement and use because of their complexity and computational expense. With further development and the increase in computing power, they offer great potential to explore the links between microscopic structure and macroscopic parameters in quantitative imaging of tissue optics and validate the accuracy of parametric models, such as single scattering or EHF.…”

Section: Modeling Of the Oct Signal With Maxwell's Equationsmentioning

confidence: 99%

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

et al. 2020

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Significance: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT attenuation coefficient and developing them toward clinical applications. Aim: Our review provides an overview of the main models and methods, their assumptions and applicability, together with a survey of preclinical and clinical demonstrations and their translation potential. Results: The use of the attenuation coefficient, particularly when presented in the form of parametric en face images, is shown to be applicable in various medical fields. Most studies show the promise of the OCT attenuation coefficient in differentiating between tissues of clinical interest but vary widely in approach. Conclusions: As a future step, a consensus on the model and method used for the determination of the attenuation coefficient is an important precursor to large-scale studies. With our review, we hope to provide a basis for discussion toward establishing this consensus.

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“…OCT image formation models based on Maxwell's equations are now beginning to be employed to study image formation in optical coherence tomography (OCT) [1]- [4]. The pseudo-spectral time-domain (PSTD) has been has been adapted for this purpose [5] and allows the sample to be discretised using grid cells approaching λ/2 where λ is the smallest wavelength in the source spectrum.…”

Section: Introductionmentioning

confidence: 99%

Accurate Representation of Microscopic Scatterers in Realistic Simulation of OCT Image Formation

Ossowski

Curatolo

Sampson

et al. 2018

2018 IEEE Photonics Conference (IPC)

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There is currently much interest in developing OCT image formation models based on Maxwell's equations. However, all such models face a common challenge: how can microscopic scatterers be represented without limiting the overall size of the sample that can be modelled? Here we show how microscopic scatterers can be accurately represented on computational grids with cells too large to faithfully represent such scatterers using conventional approaches. We also validate this approach experimentally. This approach to OCT image simulation allows for image formation for biological tissues to be simulated with unprecedented realism.

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Optical coherence tomography images simulated with an analytical solution of Maxwell’s equations for cylinder scattering

Cited by 19 publications

References 45 publications

Full-wave analysis of the scattering of a pulsed light beam by dielectric cylinders embedded in a homogeneous medium

Full-wave analysis of the scattering of a pulsed light beam by dielectric cylinders embedded in a homogeneous medium

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

Accurate Representation of Microscopic Scatterers in Realistic Simulation of OCT Image Formation

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