Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy

Banzhaf, Christina Alette; Themstrup, Lotte; Ring, Hans Christian; Mogensen, Mette; Jemec, Gregor B. E.

doi:10.1111/srt.12102

Cited by 53 publications

(53 citation statements)

References 22 publications

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“…Nevertheless, it is still difficult to discriminate between BCC subtypes despite a new proposed algorithm in high-definition OCT [16–19]. As well as for initial diagnosis, OCT is also used for treatment monitoring of BCC [20–23]. …”

Section: Resultsmentioning

confidence: 99%

Imaging Blood Vessel Morphology in Skin: Dynamic Optical Coherence Tomography as a Novel Potential Diagnostic Tool in Dermatology

Schuh

Holmes

Ulrich³

et al. 2017

Dermatol Ther (Heidelb)

103

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Conventional optical coherence tomography (OCT) enables the visualization of morphological changes of skin cancer. The use of OCT in the diagnostic investigation and in the therapy decision of non-melanoma skin cancer and other skin changes is already established, and has found its way into routine practice. With the development of speckle-variance OCT, also named dynamic OCT (D-OCT), the vascular architecture and the blood flow of the skin can be displayed in vivo and in 3D. This novel angiographic variant of OCT offers the ability to visualize and measure vessel morphology providing a new insight into healthy, inflammatory and neoplastic skin lesions such as malignant melanoma. This review focuses on the possibilities of using D-OCT on healthy and diseased skin. We suggest and illustrate key diagnostic characteristics by analyzing the initial publications and preliminary unpublished data on vessel morphology and distribution. The potential of D-OCT as a diagnostic tool in dermatology is examined and may give rise to future studies on D-OCT, which are needed to confirm the aforementioned features.

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Section: Resultsmentioning

confidence: 99%

Imaging Blood Vessel Morphology in Skin: Dynamic Optical Coherence Tomography as a Novel Potential Diagnostic Tool in Dermatology

Schuh

Holmes

Ulrich³

et al. 2017

Dermatol Ther (Heidelb)

103

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“…RCM images can be optically stitched to form horizontal mosaics of up to 8 × 8 mm using integrated software. Thus, OCT and RCM technologies may complement one another to detect BCCs . OCT and RCM have been applied, mostly individually, to monitor topical and surgical treatments of BCC and could be valuable tools to monitor AFL‐assisted IM treatment of BCCs …”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinoma treated with combined ablative fractional laser and ingenol mebutate – an exploratory study monitored by optical coherence tomography and reflectance confocal microscopy

Banzhaf

Phothong

Suku

et al. 2019

Acad Dermatol Venereol

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Background Basal cell carcinomas (BCCs) have previously been treated off‐label with ingenol mebutate (IM). Ablative fractional laser (AFL) may improve efficacy of IM by increasing drug uptake in the tumour. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) detect BCC non‐invasively. Our aim was to investigate BCC response and tolerability after combined AFL and IM treatment of low‐risk BCCs. Methods Twenty patients with histologically verified superficial (n = 7) and nodular (n = 13) BCCs were treated with combined fractional CO2‐laser (10 600 nm) and IM 0.015% or 0.05%, the concentration depending on anatomical location. BCC response was evaluated clinically, by OCT and RCM at day 29 and 90 after first treatment, and histologically at day 90. Treatment was repeated at day 29 if BCC persisted. Local skin reactions (LSRs) were assessed using LSR scale at all visits. Results At day 29, 18/20 patients received a second treatment due to residual BCC detected clinically, by OCT or RCM. OCT and RCM presented subclinical BCCs in five of 20 cases (25%). At day 90, overall histological cure rate was 70%, corresponding to clinical (65%) and OCT/RCM (60%) cure rates, and agreement between evaluation methods was substantial (kappa ≥ 0.796, P < 0.0001). Clearance rates were similar for sBCCs and nBCCs (P = 0.354) and for lesions treated with IM 0.015% and 0.05% (P = 0.141). LSRs were tolerable, but scarring was observed in the majority of cleared patients. Conclusion Two treatments of combined AFL and IM show potential to treat low‐risk BCCs with acceptable tolerability. OCT and RCM show promise to detect subclinical BCCs at short‐term follow‐up.

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“…Combining major and minor OCT criteria for pattern analysis of the tissue enables diagnosis of BCC with a specificity of ∼75% and a sensitivity of ∼96% [2,7] and can also aid in the monitoring of medical treatments of BCC lesions [20,21,22]. An algorithm has been proposed for the subclassification of BCC using high-definition OCT but awaits further validation, while there is currently no data to suggest that standard OCT can reliably differentiate between BCC subtypes [5,23,24,25].…”

Section: Basal Cell Carcinomamentioning

confidence: 99%

Dynamic Optical Coherence Tomography in Dermatology

Ulrich¹,

et al. 2016

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Optical coherence tomography (OCT) represents a non-invasive imaging technology, which may be applied to the diagnosis of non-melanoma skin cancer and which has recently been shown to improve the diagnostic accuracy of basal cell carcinoma. Technical developments of OCT continue to expand the applicability of OCT for different neoplastic and inflammatory skin diseases. Of these, dynamic OCT (D-OCT) based on speckle variance OCT is of special interest as it allows the in vivo evaluation of blood vessels and their distribution within specific lesions, providing additional functional information and consequently greater density of data. In an effort to assess the potential of D-OCT for future scientific and clinical studies, we have therefore reviewed the literature and preliminary unpublished data on the visualization of the microvasculature using D-OCT. Information on D-OCT in skin cancers including melanoma, as well as in a variety of other skin diseases, is presented in an atlas. Possible diagnostic features are suggested, although these require additional validation.

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Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy

Cited by 53 publications

References 22 publications

Imaging Blood Vessel Morphology in Skin: Dynamic Optical Coherence Tomography as a Novel Potential Diagnostic Tool in Dermatology

Imaging Blood Vessel Morphology in Skin: Dynamic Optical Coherence Tomography as a Novel Potential Diagnostic Tool in Dermatology

Basal cell carcinoma treated with combined ablative fractional laser and ingenol mebutate – an exploratory study monitored by optical coherence tomography and reflectance confocal microscopy

Dynamic Optical Coherence Tomography in Dermatology

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