Optical Coherence Tomography in Asteroid Hyalosis

Hwang, J.; Barile, Gaetano R.; Schiff, William M.; Ober, Michael D.; Rjh, Smith; Priore, Lucian V. Del; Turano, M.R.; Chang, Stanley

doi:10.1097/01.iae.0000224502.33905.66

Cited by 27 publications

(13 citation statements)

References 9 publications

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“…It is interesting that VHDs were also observed in the preoperative OCT. The nature of preoperative VHDs can be aggregation of collagen fibrils [21] or asteroid bodies presenting as hyper-reflective lesions in OCT. [22] , [23] The vitreous body contains hyalocytes and fibroblasts, although the number is small. [24] Hyalocytes range from 10 to 15 µm in diameter, and fibroblasts are usually localized in the cortex near the ciliary processes, vitreous base, and adjacent to the optic disc.…”

Section: Discussionmentioning

confidence: 99%

Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery

Chuck

Rock

et al. 2014

PLoS ONE

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PurposeTo report the observation of hyper-reflective dots in the vitreous cavity using spectral domain optical coherence tomography (SD-OCT) after uneventful phacoemulsification cataract surgery and to investigate their association with cystoid macular edema (CME).Materials and MethodsMedical records of consecutive Asian patients who had no preoperative retinopathy and underwent uneventful phacoemulsification cataract surgery from March 2012 through February 2013 were reviewed. SD-OCTs were performed before, 1 week, and 1 month after surgery. The number of vitreous hyper-reflective dots (VHDs) was counted in 5 OCT images of high-definition 5-line raster scans. The development of CME was assessed using postoperative 1-month OCT.ResultsIn 74 eyes of 74 patients, all of three SD-OCTs with a signal to noise ratio of 0.6 or more were available and were analyzed in this study. In preoperative OCT, the VHD was observed in 2 (2.7%) of 74 eyes; one eye had 1 VHD and the other eye had 2 VHDs. In 72 eyes with no preoperative VHD, VHDs were observed in 40 (55.6%) eyes at 1 week after the surgery. In the multivariate analysis, the number of VHDs measured at 1 week after the surgery was significantly associated with CME development at 1 month after the surgery (odds ratio = 1.93, 95% confidence interval = 1.15 to 3.24, P = 0.012).ConclusionsVHDs were frequently observed in OCT after uneventful phacoemulsification cataract surgery. VHDs observed at 1 week after the surgery may be a risk factor for the development of pseudophakic CME. Further studies are needed to identify the source of the VHDs.

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Section: Discussionmentioning

confidence: 99%

Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery

Chuck

Rock

et al. 2014

PLoS ONE

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“…OR CI 95% Weight Moss et al (2001) 2.20 1.66-2.93 38.8% Mitchell et al (2003) 2.54 1.25-5.16 14.2% Fawzi et al (2005) 1.40 0.98-1.99 32.8% Kim et al (2008) 1.32 0.65-2.68 14.2% Overall 1.80 1.32-2.45 100% Cochran's Q 5.4 I 2 , CI 95% 44.9 0.0-81.6 that enable fundus examination without artificial pupil dilation, such as scanning laser ophthalmoscopy and optical coherence tomography, may suffer from vitreous opacities (Browning & Fraser 2004;Hwang et al 2006;Alasil et al 2014;Saurabh et al 2018). Findings of Alasil et al (2014) suggest, however, that the faster technique of swept-source OCT may have advantages in this regard over spectral-domain optical coherence tomography in eyes with asteroid hyalosis.…”

Section: Referencesmentioning

confidence: 99%

Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta‐analysis

Møller-Lorentzen

Eckmann-Hansen

Faber

et al. 2020

Acta Ophthalmologica

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Asteroid hyalosis is defined by the presence of white, snowball‐like non‐crystalline vitreous opacities that move with the vitreous and appear to be anchored to its matrix. Asteroid hyalosis commonly occurs in the absence of other identifiable ocular abnormalities and is usually an incidental finding. The vitreous opacities are usually invisible to the patient and asymptomatic, but asteroid hyalosis can be a significant obstacle to the examination of the fundus. The prevalence increases dramatically with age. The aetiology is unknown. We systematically reviewed the literature for epidemiological data, qualitatively reviewed available studies, conducted meta‐analyses with demographical stratifications, evaluated temporal changes and estimated the future prevalence using forecasting analysis. Nine eligible studies were identified with data on 104 569 individuals. The overall population prevalence of asteroid hyalosis was 0.75% (95% confidence interval: 0.39–1.21%); however, the prevalence was highly age‐dependent, ranging from 0.27% (95% confidence interval 0.12–0.49%) in individuals aged 0–39 years and gradually increasing to 3.07% (95% confidence interval 1.90–4.50%) in individuals aged ≥80 years. Male gender was an additional risk factor (odds ratio 1.80, 95% confidence interval 1.32–2.45, p = 0.00017). The estimated global prevalence was 10.7 million subjects in year 1950, which is expected to increase to 41.5 million in year 2020 and 91.2 million in year 2100. The prevalence of asteroid hyalosis is relevant because it impacts the utility of diagnostic strategies, especially screening methods for conditions such as diabetic retinopathy.

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“…In recent studies, optical coherence tomography (OCT) has been presented pre-dominantly as a microscopic imaging technique for in vivo examination of the posterior and the anterior segment. [1][2][3][4][5][6][7][8][9][10][11] OCT has also been used to examine novel measurements such as the inferior tear meniscus [12][13][14] and the tear film between the lens and the eye. 15 Traditional uses in corneal pachymetry are extensive [16][17][18][19][20][21][22] but some have added the ability to measure the corneal epithelium.…”

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confidence: 99%

Metrics of the normal cornea: anterior segment imaging with the Visante OCT

Sorbara

Maram

Fonn

et al. 2010

Clinical and Experimental Optometry

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Purpose:The purpose of the study was to obtain anterior segment biometry for 40 normal eyes and to measure variables that may be useful to design large diameter gas permeable contact lenses that sit outside the region normally viewed by corneal topographers. Also, the distribution of these variables in the normal eye and how well they correlated to each other were determined. Methods: This is a cross-sectional study, in which data were collected at a single study visit. Corneal topography and imaging of the anterior segment of the eye were performed using the Orbscan II and Visante OCT. The variables that were collected were horizontal K reading, central corneal/scleral sagittal depth at 15 mm chord, and nasal and temporal angles at the 15 mm chord using the built-in software measurement tools. Results: The central horizontal K readings for the 40 eyes were 43 Ϯ 1.73 D (7.85 Ϯ 0.31 mm), with Ϯ 95% confidence interval (CI) of 38.7 (8.7 mm) and 46.6 D (7.24 mm). The mean corneal/scleral sagittal depth at the 15 mm chord was 3.74 Ϯ 0.19 mm and the range was 3.14 to 4.04 mm. The average nasal angle (which was not different from the temporal angle) at the 15 mm chord was 39.32 Ϯ 3.07 degrees and the Ϯ 95%CI was 33.7 and 45.5 degrees. The correlation coefficient comparing the K reading and the corneal/ scleral sagittal depth showed the best correlation (0.58, p < 0.001). The corneal/scleral sagittal depth at 15 mm correlated less with the nasal angle (0.44, p = 0.004) and the weakest correlation was for the nasal angle at 15 mm with the horizontal readings (0.32, p = 0.046). Conclusion:The Visante OCT is a valuable tool for imaging the anterior segment of the eye. The Visante OCT is especially effective in providing the biometry of the peripheral cornea and sclera and may help in fitting GP lenses with a higher percentage of initial lens success, when the corneal sag and lens sag are better matched.

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Optical Coherence Tomography in Asteroid Hyalosis

Abstract: Purpose-To demonstrate the clinical utility of OCT (optical coherence tomography) in diagnosing macular structural abnormalities in patients with asteroid hyalosis.Methods-Case series.

Cited by 27 publications

References 9 publications

Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery

Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Cystoid Macular Edema after Uneventful Phacoemulsification Surgery

Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta‐analysis

Metrics of the normal cornea: anterior segment imaging with the Visante OCT

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