Optical coherence tomography in diagnosing inflammatory diseases of ENT

Meller, Alina; Shakhova, Maria; Rilkin, Yuriy; Novozhilov, Alexey; Kirillin, Mikhail; Шахов, А. В.

doi:10.1515/plm-2014-0025

Cited by 12 publications

(8 citation statements)

References 17 publications

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“…The revealed changes in the CP OCT characteristics are comparable with the results of our previous studies of urinary bladder 48,49 and urethra 50 and investigations of other groups. 51,52 Using OCT, Meller et al 51 demonstrated thinning of the epithelium in atrophic rhinitis. Pan et al 52 showed the partially and completely denudated urothelium following chemically induced in-°a mmation.…”

Section: Discussionmentioning

confidence: 99%

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

Kiseleva

Moiseev

Kuyarov

et al. 2020

J. Innov. Opt. Health Sci.

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The paper presents the results of a study of the female urethra in cases of urethral pain syndrome (UPS) and inflammatory diseases of the lower urinary tract using cross-polarization optical coherence tomography (CP OCT). Urethral wall structure was studied in 86 patients; 233 CP OCT images were collected. A comparative qualitative analysis of three groups of CP OCT images — “norm”, “Inflammation” and “UPS” — identified that despite the absence of a clear inflammatory factor in the patient’s examination, the urethral tissues in UPS were in an altered state. The changes in the urethral wall with UPS and in cases of inflammation were similar. Using a point scale, three experts independently performed visual scoring of the CP OCT images. Three parameters: epithelial contrast, cavities and the minimum signal depth in the co-channel were evaluated. It was found that, individually, the parameters correlate only weakly with the diagnosis. Area under the receiver operating characteristic (ROC) curve was from 0.51 to 0.78. The joint use of a number of visual signs has a greater diagnostic value than the use of the criteria individually. Area under the ROC curve using the developed cumulative criterion reached up to 0.87–0.89. This study could form the basis of a scoring system for assessing the state of the urethral tract using CP OCT images in real time. The CP OCT method provides information on the state of urethral tissues that cannot be obtained with traditional cystoscopy.

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Section: Discussionmentioning

confidence: 99%

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

Kiseleva

Moiseev

Kuyarov

et al. 2020

J. Innov. Opt. Health Sci.

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“…24 In rhinology, OCT has been used to examine changes to the nasal septum mucosa following septoplasty, different types of rhinitis, and decongestant use. 25-27…”

Section: Discussionmentioning

confidence: 99%

“…24 In rhinology, OCT has been used to examine changes to the nasal septum mucosa following septoplasty, different types of rhinitis, and decongestant use. [25][26][27] OCT Imaging of the TM The recent focus of clinical OCT imaging of the TM (see Table 1 for the last 5 years; for all studies used for this review, see Supplemental Table S1 in the online version of the article) has been on improving the diagnosis of OM, where handheld OCT probes (Figure 4a) have demonstrated the ability to detect the presence of biofilm behind the TM, which is suggestive of chronic OM. [28][29][30] Using OCT-detected biofilm to diagnose chronic OM, 1 study with 20 patients reported higher diagnostic sensitivity (83% vs 74%) and specificity (98% vs 60%) over standard otoscopy.…”

Section: Oct Working Principles Development and Clinical Applicationmentioning

confidence: 99%

Optical Coherence Tomography of the Tympanic Membrane and Middle Ear: A Review

Tan

Maria

Wijesinghe

et al. 2018

Otolaryngol.--head neck surg.

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Objective To evaluate the recent developments in optical coherence tomography (OCT) for tympanic membrane (TM) and middle ear (ME) imaging and to identify what further development is required for the technology to be integrated into common clinical use. Data Sources PubMed, Embase, Google Scholar, Scopus, and Web of Science. Review Methods A comprehensive literature search was performed for English language articles published from January 1966 to January 2018 with the keywords "tympanic membrane or middle ear,""optical coherence tomography," and "imaging." Conclusion Conventional imaging techniques cannot adequately resolve the microscale features of TM and ME, sometimes necessitating diagnostic exploratory surgery in challenging otologic pathology. As a high-resolution noninvasive imaging technique, OCT offers promise as a diagnostic aid for otologic conditions, such as otitis media, cholesteatoma, and conductive hearing loss. Using OCT vibrometry to image the nanoscale vibrations of the TM and ME as they conduct acoustic waves may detect the location of ossicular chain dysfunction and differentiate between stapes fixation and incus-stapes discontinuity. The capacity of OCT to image depth and thickness at high resolution allows 3-dimensional volumetric reconstruction of the ME and has potential use for reconstructive tympanoplasty planning and the follow-up of ossicular prostheses. Implications for Practice To achieve common clinical use beyond these initial discoveries, future in vivo imaging devices must feature low-cost probe or endoscopic designs and faster imaging speeds and demonstrate superior diagnostic utility to computed tomography and magnetic resonance imaging. While such technology has been available for OCT, its translation requires focused development through a close collaboration between engineers and clinicians.

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“…Для объективизации оценки диагностических изображений часто применяются методы численного анализа изображений . Одним из основных подходов является анализ текстуры ОКТ-изображений, основанный на построении гистограммы всего изображения или его части [20,22] . Гистограмма представляет собой распределение пикселей изображения по величине ОКТ-сигнала (яркости пиксела) .…”

Section: численный анализ окт-изображенийunclassified

Differential diagnosis of various forms of chronic rhinitis based on optical coherence tomography

Shakhova¹,

Meller²,

Soloviev³

et al. 2019

Ross. rinol.

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Хронический ринит (ХР)-распространенное воспалительное заболевание, значительно влияющее на качество жизни. Диф ференциальная диагностика различных форм ХР затруднена изза отсутствия объективных безопасных методов, основанных на морфологической верификации. Цель исследования-показать возможность оптической когерентной томографии (ОКТ) для дифференциальной диагно стики различных форм ХР. Исследование проведено на базе ЛОРотделения ГБУЗ НО «Нижегородская областная клиниче ская больница им. Н.А. Семашко». С помощью ОКТ обследован 51 пациент в возрасте 32-74 лет. Предложен метод класси фикации диагностических изображений слизистой оболочки носа, основанный на аппроксимации гистограммы изображения аналитической функцией. В работе показано, что ОКТ способна неинвазивно в режиме реального времени детектировать морфофункциональные особенности слизистой оболочки полости носа в норме и при различной воспалительной патологии. Автоматизированная классификация дает возможность объективизировать трактовку ОКТизображений, обеспечивая чув ствительность метода на уровне 89%. Использование метода ОКТ позволит улучшить дифференциальную диагностику раз личных форм ХР и оптимизировать лечебную тактику.

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Optical coherence tomography in diagnosing inflammatory diseases of ENT

Cited by 12 publications

References 17 publications

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

Optical Coherence Tomography of the Tympanic Membrane and Middle Ear: A Review

Differential diagnosis of various forms of chronic rhinitis based on optical coherence tomography

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