Optical Coherence Tomography (OCT) Device Independent Intraretinal Layer Segmentation

Ehnes, Alexander; Wenner, Yaroslava; Friedburg, Christoph; Preising, Markus N.; Bowl, Wadim; Sekundo, Walter; Bexten, Erdmuthe Meyer zu; Stieger, Knut; Lorenz, Birgit

doi:10.1167/tvst.3.1.1

Cited by 39 publications

(39 citation statements)

References 51 publications

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“…To date, most studies in this area, and with good indications of reliability, focused in particular on healthy participants and used automatic algorithms [22][23][24][25][26][27] . However, the presence of a pathology and/or retinal manual segmentation or manual correction at certain locations are/is repeatedly referred to as essential to decrease measurement variability and to improve reproducibility [44] .…”

Section: Limitationsmentioning

confidence: 99%

Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

Camacho

Dutra-Medeiros²,

Paris³

2017

Ophthalmologica

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Purpose: To evaluate ganglion cell layer (GCL) and ganglion cell complex (GCC) thickness manually by spectral-domain optical coherence tomography in subjects with early and intermediate age-related macular degeneration (AMD) in 12 locations on the horizontal meridian. Methods: A total of 450 eyes (specifically, 246 eyes classified as having early/intermediate AMD plus 204 control eyes) were studied. Mann-Whitney U and Kruskal-Wallis tests were used to compare values between the healthy controls and the AMD group and also between the subgroups under study. Diagnostic performance was also compared calculating the areas under the receiver operating characteristic curve. Results: The manual layer segmentation showed clear boundaries between the GCL and the GCC. It was in the temporal GCC that more changes were found. Conclusions: The GCC, especially in the temporal region, allowed the discrimination of differences between various subgroups that have faint variations as well as between early AMD and the first signs of aging.

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Section: Limitationsmentioning

confidence: 99%

Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

Camacho

Dutra-Medeiros²,

Paris³

2017

Ophthalmologica

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“…To date, most studies, with good indications of reliability, have focused particularly on healthy participants and have used automatic algorithms [45][46][47][48][49][50]. However, in the presence of pathology, manual segmentation or manual correction at certain locations is considered essential to decrease the measurement variability and improve reproducibility [51].…”

Section: Limitationsmentioning

confidence: 99%

Outer Retina and Choroidal Thickness in Intermediate Age-Related Macular Degeneration: Reticular Pseudodrusen Findings

Camacho

Dutra-Medeiros

Cabral³

et al. 2017

Ophthalmic Res

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Purpose: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). Methods: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 µm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study. Outer retina and choroidal thickness were manually segmented and quantified at 12 locations in the horizontal meridian. Results: RPD appeared to be associated with thinning of the outer layers even after adjustment forgender and age. The presence of RPD in iAMD decreased with increase of choroidal thickness (total odds ratio [OR] 0.991, 95% confidence interval [CI] 0.985-0.996; nasal OR 0.992, 95% CI 0.986-0.997), with increased thickness of the myoid zone of the photoreceptors (total OR 0.812, 95% CI 0.688-0.958; nasal OR 0.863, 95% CI 0.755-0.987) and with increased thickness of the outer segment of the photoreceptors (total OR 0.850, 95% CI 0.731-0.989; nasal OR 0.857, 95% CI 0.736-0.989). Conclusions: The greatest differences between eyes with and without RPD are found at the level of the choroidal thickness and at the level of the photoreceptors.

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“…If multiple images were obtained in the same patient, the highest-quality image was segmented. The automated segmentation software (Di-OCTA [21]) allows a device-independent OCT analysis employing a consistent definition of layer boundaries and segments up to 11 intraretinal layers in OCT. The software comprises different analysis methods such as thickness profiling, thickness mapping, and layer combination.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

“…The software comprises different analysis methods such as thickness profiling, thickness mapping, and layer combination. A detailed explanation regarding the functionality of the software tool is published in Ehnes et al [21].…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Structure-Function Correlation in Hemianopic Vision Loss in Children Aged 3-6 Years Using OCT and SVOP, and Comparison with Adult Eyes

Bowl

Knobloch²,

Schweinfurth³

et al. 2018

Ophthalmic Res

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Purpose: To correlate visual field assessment with saccadic vector optokinetic perimetry (SVOP) in children with ganglion cell loss due to anterior pathway pathologies resulting in hemianopic visual field defects measured with optical coherence tomography (OCT). Methods: 5 young (aged 3-6 years) and 5 adult patients with hemianopia, 10 healthy preschoolers (mean age 4.4 years), and 10 healthy adults (mean age 25.3 years) were tested with SVOP and OCT (focusing on the ganglion cell layer, GCL+). In adults, visual field testing was also performed with static and fundus-controlled perimetry. Results: OCT allowed precise structure analysis and showed a vertical border with GCL+ loss on the hemianopic side in children and adults compared to controls. SVOP showed visual field defects on the hemianopic side in peripheral regions and inadequate results at the parafoveal positions in both groups. In contrast, static and fundus-controlled perimetry showed a clear border in foveal and parafoveal regions. Conclusions: All children underwent SVOP with minimal restrictions, allowing functional evaluation of peripheral visual field positions. Parafoveal positions showed multiple false-positive results. The function-structure relationship is measurable even in young children by using the GCL+ analysis. This combination of novel child-friendly techniques allows collecting objectively measured values and simplifies diagnosis and follow-up in treatment.

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Optical Coherence Tomography (OCT) Device Independent Intraretinal Layer Segmentation

Abstract: Potential application of the software includes routine clinical practice and multicenter clinical trials.

Cited by 39 publications

References 51 publications

Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation

Outer Retina and Choroidal Thickness in Intermediate Age-Related Macular Degeneration: Reticular Pseudodrusen Findings

Structure-Function Correlation in Hemianopic Vision Loss in Children Aged 3-6 Years Using OCT and SVOP, and Comparison with Adult Eyes

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