Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance

Holmes, Jon; Braunmühl, Tanja von; Berking, Carola; Sattler, Elke; Ulrich, Martina; Reinhold, Uwe; Kurzen, Hjalmar; Dirschka, Thomas; Kellner, Charles H.; Schuh, Sandra; Welzel, Julia

doi:10.1111/bjd.16154

Cited by 47 publications

(57 citation statements)

References 18 publications

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“…For the Fourier‐domain OCT type (FD‐OCT, used in 63% of all BCCs) they found a sensitivity of 93·7%, a specificity of 61·4% and a negative predictive value of 84·6%. These results are similar to a recent prospective, real‐life study evaluating the role of FD‐OCT in ‘pink’ lesions, showing a sensitivity of 96%, a specificity of 75% and a 31·8% improvement in diagnosis of BCC, compared with naked‐eye examination …”

supporting

confidence: 89%

Can optical coherence tomography improve the management of basal cell carcinoma?

2019

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supporting

confidence: 89%

Can optical coherence tomography improve the management of basal cell carcinoma?

2019

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“…Ugyanezen tanulmányban az OCT a BCC-k szubtípusának meghatározában közel 70%ban volt eredményes. Megemlítendő, hogy ebben a tanulmányban klinikailag nem egyértelmű léziókat vizsgáltak, így a gyakorlatban ennél pontosabbnak ígérkezik a módszer (25). Az OCT 1997-es bőrgyógyászati alkalmazása óta sikertörténetnek számít a képalkotók között.…”

Section: Optikai Koherencia Tomográfiaunclassified

Novel imaging techniques and their clinical applications in the field of dermatology

Kiss¹,

Dermatooncology²,

Anker³

et al. 2019

BVSZ

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ÖSSZEFOGLALÁSAz elmúlt évtizedekben az orvosi képalkotás fejlődése jelentős előrelépéseket hozott a bőrgyógyászatban. Bár jelenleg a hisztopatológiai vizsgálat az "arany standard" diagnosztikus módszer, a már-már szövettani felbontást lehetővé tévő in vivo, non-invazív képalkotási módszerek számos bőrgyógyászati kórkép vizsgálatára hatékonyan alkalmazhatók. A szerzők összefoglalják a bőrgyógyászat területén már széleskörűen alkalmazott, valamint az ígéretes, de egyelőre kísérleti stádiumban lévő bőrgyógyászati képalkotó módszereket. Az egyes modalitások elméleti hátterének ismertetése mellett részletezésre kerülnek a különböző technikák klinikai alkalmazásának lehetőségei. Kulcsszavak: bőrgyógyászati képalkotásoptikai koherencia tomográfia -reflektancia konfokális mikroszkópianemlineáris mikroszkópia SUMMARYThe development of novel medical imaging tools has resulted in significant progression in the field of dermatology. However, histopathological evaluation still remains the gold standard diagnostic method. Novel, in vivo non-invasive imaging modalities can provide near histological resolution and can be applied in the assessment of various dermatological diseases. In this paper, the authors review the clinically applied imaging techniques among the newest experimental devices. After the description of the basic principles and imaging properties of these techniques, the authors also discuss their clinical applications.

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“…In previous studies, this could be shown using optical coherence tomography (OCT) or confocal laser scanning microscopy (RCM), when dermatoscopic findings were inconclusive. 4,5 Nevertheless, a method not being dependent on the experience of the investigator would be favorable. Spectroscopic methods such as Raman, multimodal imaging, and fluorescence methods were tested to distinguish between normal skin and skin cancer.…”

Section: Introductionmentioning

confidence: 99%

Application of parelectric spectroscopy to detect skin cancer—A pilot study

Arnold‐Brüning

Blaschke

Kramer

et al. 2019

Skin Research and Technology

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Background The early detection of skin cancer is still challenging and calls for objective, fast diagnostic, and ideally non‐invasive methods in order to leave the potentially malignant tumor cells unaltered. In this paper, the parelectric spectroscopy was applied to evaluate the potential of a non‐invasive detection of basal cell carcinoma (BCC) and malignant melanoma. Materials and Methods A prototype of parelectric spectroscopy was used to investigate non‐invasively dipole density and mobility of suspicious skin lesions. The differences in investigated tissue were analyzed compared to pathohistological findings in a clinical study on 51 patients with suspected BCC and malignant melanoma. Results The non‐invasive parelectric spectroscopy could differentiate between normal skin, BCC, and melanoma but failed to distinguish between different types of skin cancer. The data were normalized to unsuspected nearby skin because the different skin locations influence dipole density and mobility. Conclusion The results of the pilot study indicate that the parelectric spectroscopy might be an additional, useful non‐invasive diagnostic procedure to distinguish between normal skin and skin cancer.

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Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance

Abstract: OCT is useful in the diagnosis of BCC.

Cited by 47 publications

References 18 publications

Can optical coherence tomography improve the management of basal cell carcinoma?

Can optical coherence tomography improve the management of basal cell carcinoma?

Novel imaging techniques and their clinical applications in the field of dermatology

Application of parelectric spectroscopy to detect skin cancer—A pilot study

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