Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Retinal Nerve Fiber Layer Measurements of Glaucoma Patients

Fanihagh, Farsad; Anastassiou, Gerasimos; Schallenberg, Maurice; Steuhl, Klaus‐Peter; Selbach, Michael

doi:10.2174/1874364101509010041

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…As has been previously reported, the OCT showed the highest, whereas the HRT exhibited the lowest values for mean RNFL thickness (Fanihagh et al. 2015).…”

Section: Discussionsupporting

confidence: 77%

Comparison of imaging parameters between OCT, GDx and HRT in the Northern Finland birth cohort eye study

Stoor

Karvonen

Leiviskä

et al. 2021

Acta Ophthalmologica

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Purpose: The purpose of the study was to assess and compare the optic nerve head (ONH) and retinal nerve fibre layer (RNFL) parameters and image quality parameters obtained by Cirrus HD-OCT, GDxECC and HRT3 in a populationbased screening study. Methods: This analysis examined 2566 subjects taking part in the Northern Finland Birth Cohort Eye study. Images with spectral domain OCT (Cirrus HD-OCT 4000), scanning laser ophthalmoscopy (HRT3) and scanning laser polarimetry (GDxECC) were obtained from each subject. The correlation of average and regional parameters of RNFL and ONH between devices was evaluated. Results: The RNFL thickness was 90.9 µm when measured with OCT, 24.6 µm with HRT and 48.1 µm with GDx. There was a high correlation between the disc and cup measurements with the HRT and OCT and the RNFL thickness of the OCT and GDx (r > 0.5). A statistically significant correlation was found between RNFL measurements of the HRT and OCT in the superior, temporal and inferior quadrants. Optical coherence tomography (OCT) signal strength correlated with the image quality parameters of the HRT and GDx. The percentage of good quality images was the lowest with the GDx. Conclusion:The RNFL thickness in Northern Finland birth cohort was at a lower level compared to other studies. The study confirms the difference in measuring ONH parameters between the imaging devices. However, significant correlations between devices were found in the cup volume and cup disc area ratio parameters of the OCT and HRT. The correlations between image quality parameters and glaucoma detection parameters were relatively low.

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“…As has been previously reported, the OCT showed the highest, whereas the HRT exhibited the lowest values for mean RNFL thickness (Fanihagh et al. 2015).…”

Section: Discussionsupporting

confidence: 77%

Comparison of imaging parameters between OCT, GDx and HRT in the Northern Finland birth cohort eye study

Stoor

Karvonen

Leiviskä

et al. 2021

Acta Ophthalmologica

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“…Diagnostic tools such as scanning laser polarimeter (GDx; Carl Zeiss Meditec, Dublin, CA), Heidelberg retina tomographer, and scanning laser ophthalmoscope are suitable for quantitatively assessing the NFL thickness, except the NFL thickness in the macula area. 11 Ocular coherence tomography (OCT) provides non-contact and non-invasive NFL thickness measurements and has become an essential clinical measure for objective glaucoma assessment. 12 Several authors have reported NFL thickness in normal children and adults as well as those with ocular anomalies.…”

Section: Nerve Fibre Layermentioning

confidence: 99%

A review of the human retina with emphasis on nerve fibre layer and macula thicknesses

Mashige

Oduntan

2016

African Vision and Eye Health

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The retina is the innermost neural layer of the eye, and is the site of transformation of light energy into a neural signal. Knowledge and assessment of the human retinal structural parameters are important for the appropriate diagnosis and management of various ocular diseases. For instance, potentially blinding eye diseases, such as glaucoma and age-related macula degeneration, cause structural changes in the retina. Clinical evidence with ocular coherence tomography also suggests that eyes with glaucoma lose retinal nerve fibre layer and ganglion cells axons before loss of visual function. These losses appear as a visible change in the optic nerve head and can be seen before visual field abnormalities are noticed by the patient. This review discusses certain aspects (anatomical structures, structural changes with eye diseases and assessment methods) involving the human retina, their clinical importance and factors that may influence them. The content of this article will be useful to optometrists and ophthalmologists who assess these parameters in normal patients as well as in those with eye conditions such as glaucoma.Keywords: Retinal parameters; optic disc; nerve fibre layer thickness; macula thickness; glaucoma

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“…1 This condition is characterised by progressive optic neuropathy, accelerated damage of the retinal ganglion cells and axons, and thinning of the retinal nerve fibre layer (RNFL) and neuroretinal rim. 2 Recent evidence suggests that loss of ganglion cells and anomalies of the RNFL occur before functional deficits become manifest in the visual fields. 3 Objective, quantitative and sensitive assessment methods of the RNFL thickness are therefore essential to diagnose and monitor progression of optic nerve diseases, such as glaucomatous optic neuropathy and other neurological causes.…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fibre layer thickness values and their associations with ocular and systemic parameters in Black South Africans

Mashige¹,

Oduntan²

2017

Afr H. Sci.

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Purpose: To measure the retinal nerve fibre layer (RNFL) thickness values and investigate their associations with other parameters in healthy eyes of Black South Africans. Methods: 600 participants with healthy eyes, of whom 305 (50.83%) were males and 295 (49.17%) were females, with a mean age of 28.15 ± 13.09 years, underwent a detailed ophthalmic examination. RNFL thickness was measured by iVue SD-OCT. Results: The mean global RNFL thickness was 110.01 ± 7.39 μm. The RNFL was thickest inferiorly (135.06 ± 9.66 µm) and superiorly (131.72 ± 10.46 µm), thinner nasally (87.24 ± 13.22 µm), and thinnest temporally (73.63 ± 15.66 µm). Multivariate analysis showed that thicker mean global RNFL thickness was significantly associated with younger age, shorter axial length (AL) and hyperopia (p < 0.001). Mean RNFL thickness decreased by approximately 0.11 µm per year of aging life, and by 1.02 µm for each 1-mm of axial elongation. There was a 0.62 µm RNFL thickness increase for every dioptre change in spherical power towards more hyperopia. Conclusion: Mean RNFL thickness values and their associations established in this population may be of clinical value when assessing factors that influence this parameter and diagnosing diseases affecting it.

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Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Retinal Nerve Fiber Layer Measurements of Glaucoma Patients

Cited by 10 publications

References 19 publications

Comparison of imaging parameters between OCT, GDx and HRT in the Northern Finland birth cohort eye study

Comparison of imaging parameters between OCT, GDx and HRT in the Northern Finland birth cohort eye study

A review of the human retina with emphasis on nerve fibre layer and macula thicknesses

Retinal nerve fibre layer thickness values and their associations with ocular and systemic parameters in Black South Africans

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