Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria

Yang, Hongli; Luo, Haomin; Hardin, Christy; Wang, Ya Xing; Jeoung, Jin Wook; Albert, Cindy; Vianna, Jayme R; Sharpe, Glen P.; Reynaud, Juan; Demirel, Shaban; Mansberger, Steven L; Fortune, Brad; Nicolela, Marcelo T.; Gardiner, Stuart Keith; Chauhan, Balwantray C.; Burgoyne, Claude F.

doi:10.1016/j.ajo.2019.12.020

Cited by 12 publications

(11 citation statements)

References 67 publications

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“…Even the newly proposed summary metrics combining BMO–MRW and cpRNFL measures or OCT and 24-2 VF, had sensitivities of less than 80%. 14 , 15 Our proposed S–S metric was 1 of 2 metrics with the highest accuracy, 91%, although it too had a modest sensitivity of 80%.…”

Section: Discussionmentioning

confidence: 88%

“…The criterion from Yang et al ({Any (1 small + 1 MRW )}, dark red and double underline in Table 2 ), which effectively looks for the same cpRNFL/BMO–MRW agreement in any of the 6 paired sectors instead of just the TI region, correctly identified 3 more LG eyes, for a total of 29 TPs. 14 However, this improvement in sensitivity (from 65% to 73%) came at the cost of decreased specificity, to 93% with 4 FPs from the HC group.…”

Section: Resultsmentioning

confidence: 98%

“… 21 , 22 , 30 , 39 , 40 However, other recent studies have proposed new combinations of these metrics in an attempt to improve their performance. 14 , 15 , 34 Because different studies use different metrics, inclusion criteria, and reference standards, it is difficult to reconcile the results of these studies. In the present study, we evaluated the detection performance of a wide variety of metrics, based on summary statistics reported in commercially available OCT and VF reports.…”

Section: Discussionmentioning

confidence: 99%

“…We evaluated the detection performance of each OCT summary metric in isolation. In addition, we assessed various combinations of OCT metrics (i.e., structural agreement), including our new S–S metric as well as the combination of metrics described by Yang et al 14 In particular, we combined small- and large-circle cpRNFL metrics, cpRNFL, and BMO–MRW metrics (including the ones suggested by Yang et al) and cpRNFL and GCL metrics. For the purpose of this study, each of the metrics was considered abnormal if its value was at a borderline level ( P < 5%) or less.…”

Section: Methodsmentioning

confidence: 99%

“… 20 , 26 – 31 In contrast, we and others have argued that it is possible to improve diagnostic performance by taking into consideration the topographical nature of glaucomatous structural damage and/or the relationship between structural and functional abnormalities. 14 , 15 , 32 , 33 Yang et al, 14 for example, reported on the diagnostic performance when the requirement was set for an OCT abnormality to occur in topographically correspondent sectors of the minimum rim width (MRW) and the circumpapillary retinal nerve fiber layer (cpRNFL). Iyer et al 15 presented 3 diagnostic criteria, all of which paired quadrant OCT cpRFNL metrics with VF metrics; in particular, the glaucoma hemifield test (GHT) or the pattern standard deviation (PSD), depending on the chosen criterion.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry

Tsamis

Bruna

Leshno

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To evaluate the diagnostic performance of optical coherence tomography (OCT) and visual field (VF) summary statistics (metrics) that are available in OCT and VF reports. Methods OCT disc and macular scans and 24-2 and 10-2 VFs were obtained from 56 healthy control (HC) eyes/participants and 61 eyes/patients with 24-2 mean deviation of better than –6 dB. All metrics were obtained from OCT radial, circle, and posterior pole cube scans and 24-2 and 10-2 VFs. Their diagnostic performances were evaluated, in isolation and in combinations. For specificity, the 56 HC eyes were used. For sensitivity, 40 of the 61 patient eyes were deemed likely glaucomatous based on an automated topographic method that evaluates structure–function (S–F) agreement. Any 1 of these 40 eyes not judged as abnormal by any given metric was considered a false negative. Results All single OCT and VF metrics misclassified HCs as glaucomatous and missed likely glaucomatous eyes. The best performing single metric was the temporal inferior thickness of the 3.5-mm circle scan, with 96% specificity and 83% sensitivity. Combinations of OCT–OCT and OCT–VF metrics markedly improved specificity. A newly proposed metric that evaluates structure–structure (S–S) agreement at a hemifield level had the highest accuracy. This S–S metric had 98% specificity and 80% sensitivity. Conclusions OCT and VF metrics, single or in combinations, have only moderate sensitivity for eyes with early glaucoma. Translational Relevance OCT and VF metrics combinations evaluating S–S or S–F agreement can be highly specific, which is an important implication for clinical and research purposes.

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Section: Discussionmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 98%