Optical coherence tomography versus automated perimetry for follow‐up of optic neuritis

Noval, Susana; Contreras, Inés; Rebolleda, Gema; Muñoz‐Negrete, Francisco J.

doi:10.1111/j.1600-0420.2006.00724.x

Cited by 85 publications

(85 citation statements)

References 15 publications

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“…These OCTs offer faster scan speed and higher image resolution for RNFL imaging than conventional time-domain OCT. 2 Several studies have focused on the measurements and reproducibility of RNFL thickness using Stratus-OCT after optic neuritis (ON) and multiple sclerosis (MS). [3][4][5][6][7][8][9][10][11][12][13] In fact, lower RNFL values correlate with impaired visual function. OCT is a promising tool for evaluating atrophy in patients with ON and MS, and it could evolve into an important primary or secondary outcome measure for MS clinical trials and patient care.…”

Section: Introductionmentioning

confidence: 99%

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Rebolleda

García-García²,

Kim³

et al. 2010

Eye

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Purpose To study the relationship between retinal nerve fiber layer (RNFL) thickness measurements from time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT) in subjects with optic neuritis. Methods A total of 18 patients who had suffered monocular acute optic neuritis were imaged by a single trained operator using the Stratus-OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) on the same day. The relationship between RNFL thickness measurements of the two OCTs (overall and by quadrants) were evaluated using intraclass correlation coefficient (ICC) and Bland-Altman plots. Comparisons between eyes having optic neuritis (ON-group) and fellow eyes (fellow-group) were assessed by a generalized estimating equation (GEE) regression model.

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Section: Introductionmentioning

confidence: 99%

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Rebolleda

García-García²,

Kim³

et al. 2010

Eye

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“…However, correlation between RNFL thickness at 1.5 months and BCVA at six months was statistically insignificant. Correlations between RNFL thickness and BCVA, perimetry have been described in patients with ON with [10][11][12] and without [13] multiple sclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…They observed significant average RNFL loss -20.38 µm in MSON eyes (95% CI, -22.86 to -17.91). RNFL thickness in eyes affected by ON 59.79 µm-85 µm and in fellow eyes 82.73 µm-99 µm [12,21,[25][26] . In ON without evidence of MS, Costello et al [5] demonstrated RNFL thickness in affected and fellow eyes were 77.5 µm and 99.88 µm, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic determination using optical coherence tomography compared with visual functions in optic neuritis

Kitthaweesin

Sutra

2013

JBGC

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Background: The majority of optic neuritis patients often notice improvement and gain stability of their visual functions, however, evidences of ongoing retinal nerve fiber layer (RNFL) thinning have been reported. Purposes:To investigate the correlation between RNFL thickness measured with Optical coherence tomography (OCT) and visual function tests and to determine the utility of OCT in visual prognostic assessment of optic neuritis. Method:A prospective study was performed in 12 patients with acute isolated optic neuritis. Best corrected visual acuity (BCVA), Swedish interactive threshold algorithms (SITA) 30-2 strategy on Humphrey field analyzer, and fast RNFL thickness analysis were performed on both affected and fellow eyes at baseline, 1.5, three and six months.Results: Mean BCVA and average mean deviation (MD) of the affected eye were significantly different from the fellow eyes at baseline. Affected eyes had significant thinner of RNFL at baseline, 1.5, three, and six months. Significant correlations between (i) mean RNFL thickness and BCVA at 1.5 (r = 0.707, p = .010), (ii) mean RNFL thickness and MD at 1.5 months (r = 0.674, p = .016) and six months(r = 0.710, p = .032), (iii) mean RNFL thickness at 1.5 months and MD at six months (r = 0.782, p = .013). Conclusion:A correlation between RNFL thickness and visual function tests indicates that OCT might have roles in detection and prediction of RNFL damage in Optic neuritis (ON) patients despite no evidence of MS.

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“…Recent studies have shown that OCT-measured RNFL values are reduced after ON and that the extent of the RNFL atrophy correlates with diminished visual and neurological function scores. [9][10][11][12][13] Another study has reported that neuronal loss in the macular retinal ganglion cell-inner plexiform layer (GCIPL) is strongly related to visual function and vision-related quality of life in MS patients, and is observed with and without a history of acute ON. 4 A recent study reported that quantifying GCL thickness after acute ON provides opportunities for monitoring early axonal loss and ONto-MS progression in early ON.…”

Section: Introductionmentioning

confidence: 99%

Retinal ganglion cell and axonal loss in optic neuritis: risk factors and visual functions

Lee

Park

et al. 2016

Eye

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Purpose The peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cellinner plexiform layer (GCIPL) are important predictive factors for the prognosis of optic neuritis (ON). We investigated the risk factors for pRNFL and GCIPL thinning in ON and its relationship with visual function. Patients and methods We analyzed 33 eyes of 33 patients with a first attack of unilateral ON. Patients were divided into two groups according to pRNFL and GCIPL thinning, using spectral-domain optical coherence tomography. We evaluated patients' age, sex, color vision, visual acuity (VA), optic nerve findings on MRI, elapsed period from onset of visual symptoms to steroid treatment, visual field (VF) mean deviation (MD), average pRNFL thickness, and GCIPL thickness. Results There was no patient with residual VF defect in the groups without pRNFL or GCIPL thinning. Significant correlations were found between pRNFL (some sectors) and GCIPL (all sectors) thickness and BCVA and VF MD (Po0.03 for all). Multivariate logistic regression analysis revealed that only worse initial VF MD was a significant risk factor of pRFNL and GCIPL thinning after ON (OR, 0.841; 95% CI, P = 0.017 and OR, 0.871; 95% CI, P = 0.046, respectively). Conclusion Retinal ganglion cell and axonal losses occurred in ON cases showing severe initial VF loss. Therefore, it is necessary to pay more attention to the degree of initial VF loss in ON while considering the possibility of residual VF loss accompanying pRNFL and GCIPL thinning.

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Optical coherence tomography versus automated perimetry for follow‐up of optic neuritis

Cited by 85 publications

References 15 publications

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Prognostic determination using optical coherence tomography compared with visual functions in optic neuritis

Retinal ganglion cell and axonal loss in optic neuritis: risk factors and visual functions

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