Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Izquierdo-Serra, Mercè; Bautista-Barrufet, Antoni; Trapero, Ana; Garrido‐Charles, Aida; Díaz-Tahoces, Ariadna; Camarero, Núria; Pittolo, Silvia; Valbuena, Sergio; Pérez‐Jiménez, Ariadna; García-Moll, Alejandro; Rodríguez‐Escrich, Carles; Lerma, Juan; Villa, Pedro de la; Fernández, Eduardo; Pericàs, Miquel À.; Llebaría, Amadeu; Gorostiza, Pau

doi:10.1038/ncomms12221

Cited by 57 publications

(84 citation statements)

References 49 publications

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“…Moreover, we should also consider the possibilities offered by the optopharmacological approach. This technique is based on a new class of light-regulated drugs that are able to photo-control the activity of different ion channels and can be regarded as nanoprosthetic devices to remotely drive the endogenous receptors that remain in the cells (Izquierdo-Serra et al, 2016). Additionally, other researchers are starting to use magnetic stimulation from implantable micro-coils as an alternative to conventional micro-electrodes.…”

Section: Electrode-to-tissue Interface Issuesmentioning

confidence: 99%

Development of visual Neuroprostheses: trends and challenges

Fernández

2018

Bioelectron Med

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Visual prostheses are implantable medical devices that are able to provide some degree of vision to individuals who are blind. This research field is a challenging subject in both ophthalmology and basic science that has progressed to a point where there are already several commercially available devices. However, at present, these devices are only able to restore a very limited vision, with relatively low spatial resolution. Furthermore, there are still many other open scientific and technical challenges that need to be solved to achieve the therapeutic benefits envisioned by these new technologies. This paper provides a brief overview of significant developments in this field and introduces some of the technical and biological challenges that still need to be overcome to optimize their therapeutic success, including long-term viability and biocompatibility of stimulating electrodes, the selection of appropriate patients for each artificial vision approach, a better understanding of brain plasticity and the development of rehabilitative strategies specifically tailored for each patient.

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Section: Electrode-to-tissue Interface Issuesmentioning

confidence: 99%

Development of visual Neuroprostheses: trends and challenges

Fernández

2018

Bioelectron Med

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“…Photoswitchable ligands 6 enable directly controlling the activity of endogenous receptors without requiring genetic manipulation 8,11 . They can be applied to intact tissue, making drug-based phototherapies possible.…”

Section: Mainmentioning

confidence: 99%

Photocontrol of endogenous glycine receptors in vivo

Gomila

Rustler

Maleeva

et al. 2019

Preprint

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Glycine receptors (GlyRs) are indispensable to maintain excitatory/inhibitory balance in neuronal circuits controlling reflex and rhythmic motor behaviors. Here we have developed Glyght, the first GlyR ligand controlled with light. It is selective over other cys-loop receptors, active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understand inhibitory circuits in intact animals, and to develop drug-based phototherapies. Photocontrol of endogenous glycine receptors in vivoGomila et al.

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“…Light-dependent affinity labeling is possible, so patterns of light can shape where the TCP binds in the sample. When endogenous GluK1 channels are labeled with a TCP in DRG neurons and degenerate retina, the neurons become light sensitive[51]. …”

Section: Improving Synthetic Photoswitch Utility: Wavelength-shiftingmentioning

confidence: 99%