Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy

Cen, Yi; Chen, Ying; Li, Xinxuan; Chen, Xiayun; Yu, Baixue; Yan, Mengyi; Yan, Ni; Cheng, Hong; Li, Shiying

doi:10.1016/j.biomaterials.2024.122568

Biomaterials

2024

DOI: 10.1016/j.biomaterials.2024.122568

|View full text |Cite

Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy

Yi Cen,

Ying Chen,

Xinxuan Li

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Pyroptosis‐Inducing Self‐Adaptor to Potentiate Immune Checkpoint Blockade Therapy for Breast Cancer by Reeducating the Treatment‐Recruited Macrophages

Qiu,

Zhong,

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Treatment‐induced cell pyroptosis can improve the immunogenicity of breast cancer and enhance the efficacy of immune checkpoint blockade (ICB), but the resultant recruitment of immunosuppressive cells impedes the systemic anti‐tumor immunity. Herein, a rationally designed self‐adaptor (R@L‐MRS17) is developed to initiate breast cancer cell pyroptosis and concomitantly reeducate the pyroptosis‐recruited macrophages to enhance the ICB therapy. Of which, R@L‐MRS17 promotes breast cancer‐specific drug delivery through CD47 recognition, and enables the plasma membrane targeted photosensitizer insertion through hydrophobic and electrostatic interactions. Under light excitation, R@L‐MRS17 produces reactive oxygen species (ROS) in situ to trigger cell pyroptosis, followed by the release of pro‐inflammatory factors to recruit macrophages and improve tumor immunogenicity. Moreover, the acid responsiveness of R@L‐MRS17 facilitates the release of R848 to polarize the infiltrated macrophages into M1 phenotype for active anti‐tumor immunity. Additionally, R@L‐MRS17 is capable of blocking CD47 to restore the recognition and phagocytosis behavior of M1‐type macrophages against breast cancer cells. In short, the stepwise immune activation by R@L‐MRS17 significantly suppresses the bilateral tumor growth and metastasis in combination with αPD‐L1. This study provides a self‐adaptable strategy to activate the immunological cascade, which may spatiotemporally amplify the immune responses for breast cancer.

show abstract

Pyroptosis‐Inducing Self‐Adaptor to Potentiate Immune Checkpoint Blockade Therapy for Breast Cancer by Reeducating the Treatment‐Recruited Macrophages

Qiu,

Zhong,

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy

Cited by 1 publication

References 38 publications

Pyroptosis‐Inducing Self‐Adaptor to Potentiate Immune Checkpoint Blockade Therapy for Breast Cancer by Reeducating the Treatment‐Recruited Macrophages

Pyroptosis‐Inducing Self‐Adaptor to Potentiate Immune Checkpoint Blockade Therapy for Breast Cancer by Reeducating the Treatment‐Recruited Macrophages

Contact Info

Product

Resources

About