Optical Density of Subretinal Fluid in Retinal Detachment

Abstract

The increase over time in the ODR of the SRF in RRD might reflect a change in SRF composition and state of the retina. This, together with a significant association between preoperative ODR values and postoperative VA suggest its potential as a biological prognostic marker.

Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma

“…We used the region of interest (ROI) selection method described in detail elsewhere [21]. Briefly, two ROIs of identical shape and size were chosen, one for the SRF compartment and the other for the vitreous space located above it (Fig.…”

Optical Density of Subretinal Fluid as a Predictive Biomarker for Eyes With Chronic Central Serous Retinopathy Treated With Eplerenone

“…14,15 Optical density ratios have also been found to correlate with both treatment interval and visual outcomes in eyes with nAMD and visual outcomes following retinal detachment repair. 17,19 However, to the best of our knowledge after a systematic literature search on PubMed and Ovid Medline with the terms "central serous retinopathy" and "optical density," no prior studies have examined ODR as a functional and an anatomic prognostic biomarker for patients treated with eplerenone for chronic CSR.…”

“…The advantage of utilizing ODR measurements over absolute OD measurements is that calculating a ratio of OD reflectivity normalizes the optical effect of anterior ocular structures between different eyes. 14,17,19 Although patients with acute CSR typically are in the age range of 20 to 50 years old, the mean age of our study population with chronic CSR was 56 years. The univariate linear correlations found between ODR, VA, and percentage improvement in CMT were robust, but the lack of BCVA and modest sample size may have limited our ability to detect the impact of other factors (age, height of serous detachment, and eplerenone dose) on anatomic and visual recovery.…”

“…Prior studies have shown that the ODR of SRF in RRD increases over time, suggesting a change in the SRF composition and introducing the idea that ODR may be useful in monitoring the course and nature of macular disease. 16,17 One of those studies showed that lower ODR also correlates with better VA at 3 months. 17 In eyes with neovascular age-related macular degeneration (nAMD), increased ODRs were correlated with increased treatment burden.…”

“…16,17 One of those studies showed that lower ODR also correlates with better VA at 3 months. 17 In eyes with neovascular age-related macular degeneration (nAMD), increased ODRs were correlated with increased treatment burden. 18 These studies of ODR in RRD and nAMD show an association between ODR, time, and visual outcomes, which may lead one to hypothesize whether ODR may be utilized as a prognostic marker of disease activity and treatment response.…”