The design of 21 mega-pixel mobile phone lens was introduced, which uses three aspherical optical plastic lenses, APL5514ML, OKP4HT, and E48R, and uses ZEMAX optical design software to design a mobile phone lens with up to 21 million pixels, the optical system has four aspherical optical plastic lenses, and another K9 filter is added to protect the CMOS sensor negative. The first and second lenses are negative and the third and fourth lenses are positive. The design results show that the modulation transfer function (MTF) of the central field of view at 1/2 Nesquith frequency is greater than 0.5, the MTF values at the full field of view are greater than 0.3, the aberration is less than 2 %, the relative illumination is greater than 50 %.