Optical Detection of Protein Adsorption on Doped Titanium Surface

Silvennoinen, Raimo; Penttinen, Niko; Silvennoinen, Martti; Hasoň, Stanislav; Vetterl, Vladimír; Bartáková, Sonia; Prachár, Patrik; Vaněk, Jiřı́; Březina, Vítězslav

doi:10.5772/23294

Cited by 2 publications

(1 citation statement)

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“…Because of its important role in adhesion it is usually used in studies to determine a surface's ability in protein adsorption. As proteins adsorb onto the surface a layer is being formed, the structure and composition of which controls the character of the following biological reactions, such as bone or soft tissue formation, and its extent [58,59]. It is with this layer that platelets and inflammatory cells react and not with the surface itself.…”

Section: Protein/cell Interactions and Surface Topographymentioning

confidence: 99%

Advances on Biomedical Titanium Surface Interactions

Bousnaki¹,

Koidis²

2014

JBBTE

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When used as an implanted material, titanium (Ti) surface controls the subsequent biological reactions and leads to tissue integration. Cells interactions with the surface, through a protein layer that is being formed from the moment Ti surface comes in contact with blood and its components, and indeed this protein layer formation, are regulated by surface properties such as topography, chemistry, charge and surface energy. Currently, the implementation of nanotechnology, in an attempt to support mimicking the natural features of extracellular matrix, has provided novel approaches for understanding and translating surface mechanisms whose modification and tailoring are expected to lead to enhanced cell activity and improved integration. Despite the fact that there has been extensive research on this subject, the sequence of interactions that take place instantly after the exposure of the implanted material into the biologic microenvironment are not well documented and need further investigation as well as the optimization of characteristics of Ti surface. This review, including theoretical and experimental studies, summarizes some of the latest advances on the Ti surface concerning modifications on surface properties and how these modifications affect biomolecular reactions and also attempts to present the initial adsorption mechanism of water and protein molecules to the surface.

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Section: Protein/cell Interactions and Surface Topographymentioning

confidence: 99%