Optical detection of small biomolecule thiamines at a micromolar level by highly luminescent lanthanide complexes with tridentate N-heterocyclic ligands

Abstract

Based on the luminescence properties of lanthanide complexes, we found that very fast and extremely sensitive optical detection of thiamines can be achieved for the first time.

Synthesis, Characterization and Crystal Structure of Samarium(III)-(E)-1-phenyl-N-(4H-1,2,4-triazol-4-yl)methanimine Complex

“…Using lanthanide coordination compounds with organic ligands including aromatic moieties is one solution to this challenge. The inclusion of pyridyl and triazole moieties in organic molecules, for example, ensures efficient energy absorption, resulting in an increase in the luminescence of metal ions via indirect excitation [14][15][16][17][18][19] . In compounds with magnetically active metal ions, triazole bridges also mediate exchange coupling between paramagnetic centers via the M-N-N-M channels, which have short metal-nitrogen and nitrogen-nitrogen connections [20][21][22][23][24] .…”

Syntheses, Structures, and Photoluminescence Properties of a Series of 3D Zn‐Ln Heterometallic Complexes with 2,3‐Pyrazine Dicarboxylic Acid as a Bridging Ligand

“…For example, highly luminescent Ln III complexes ( Ln = Eu, Sm, Nd) with β‐diketone ligands were synthesized by Bassett et al Near‐IR luminescent ytterbium complexes with four Salen‐type ligands were reported . Du et al have reported a new series of Ln III complexes ( Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb) with tridentate N ‐heterocyclic ligand emitting strong luminescence with high efficiency . When aromatic carboxylic acids are served as organic ligands, lanthanide ions exhibit higher thermal or luminescent stability than other organic ligands for practical applications by virtue of their dimeric or infinite chain polymer structures .…”

Functional Sensing Materials Based on Lanthanide N-Heterocyclic Polycarboxylate Crystal Frameworks for Detecting Thiamines

“…7,8 In the meantime, lanthanide coordination polymers containing N-heterocyclic ligands show excellent luminescence by the antenna effect, in general, in which the N-heterocyclic ligand function is as a sensitizer. 9−11 In this aspect of the work, the ligand H 2 L {2,6-bis(5-methyl-1H-pyrazol-3-yl)pyridine} 12 was extensively investigated. Furthermore, the "-NH" in the H 2 L ligand (including pyrazole and pyridine) can act as Lewis base donors and Lewis acid acceptors in the same molecule.…”

“…Furthermore, the "-NH" in the H 2 L ligand (including pyrazole and pyridine) can act as Lewis base donors and Lewis acid acceptors in the same molecule. 9,12 Up to now, the crystal structures of some related compounds with 2,6-bis(5-methyl-1H-pyrazol-3-yl)pyridine (H 9,12 Although these molecules (tridentate N-heterocyclic ligand) can also serve as efficient antenna to sensitize the emission of lanthanide ions, exploration application studies about such kinds of coordination polymers are still quite limited.…”

“…15−22 Luminescent metal−organic coordination polymers are well explored as chemical sensor materials, because of their narrow spectral width, stable chemical structure, and long fluorescence lifetime, 13 in applications such as detection of explosive nitroaromatics; 6,8,11,23−29 detection of metal cations; 7,30−35 detection of anions; 7,36−38 sensing of organic small molecules; 17,31,39−42 sensing of solvent molecules; and so on. 40,43 In addition, thiamines are also called vitamin B1, 44,45 and include three kinds of thiamine: thiamine hydrochloride (TCl), 12, 44, 46− 49 thiamine monophosphate chloride (TMP), 12,47,50,51 and thiamine pyrophosphate chloride (TPP) 12,52−57 (Scheme 1). As an important small biomolecule, when an organism lacks thiamines, the following response can appear in turn, such as dry beriberi, wet beriberi, wernicke encephalopathy, Korsakoff syndrome, and so on.…”