Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media

Abstract

An optical Doppler tomography (ODT) system that permits imaging of fluid flow velocity in highly scattering media is described. ODT combines Doppler velocimetry with the high spatial resolution of low-coherence optical interferometry to measure fluid flow velocity at discrete spatial locations. Tomographic imaging of particle flow velocity within a circular conduit submerged 1 mm below the surface in a highly scattering phantom of Intralipid is demonstrated.

Optical coherence tomography for the quantitative study of cerebrovascular physiology

“…Doppler optical coherence tomography (DOCT) is a path length-resolved optical imaging technique that can measure velocity axial projections in welldefined microscopic volumes (Chen et al, 1997;Leitgeb et al, 2003). Doppler OCT velocity axial projections can be used to perform absolute measurements of blood flow either by estimating vessel angles (Wang et al, 2007b) or by processing volumetric data (Srinivasan et al, 2010b).…”

Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera

“…OCT technique enables two-or three-dimensional (2-D or 3-D) cross-sectional imaging with micrometer resolution [1][2][3][4]. Besides morphology, OCT reveals and visualizes such properties of biological objects as velocity of flow (via Doppler effect), birefringence (via polarization changes) and tissue extinction [5][6][7][8][9][10][11][12].…”

Photoacoustic Doppler flow measurement in optically scattering media

“…It usually can measure only the averaged flow speed in a tissue volume of ϳ1 mm 3 with no information about the flow direction. 5 Optical Doppler tomography 7 alleviates the multiple light scattering problem by combining the principles of laser Doppler and of coherent gating to detect singly backscattered light from RBC. It can detect flow as slow as ϳ100 m / s with a spatial resolution of ϳ5 ϫ 5 ϫ 15 m 3 .…”