Optical Fiber DNA Biosensor With Temperature Monitoring Based on Double Microcavities Fabry–Perot Interference and Vernier Combined Effect

Li, Xuegang; Li, Fei; Zhou, Xue; Zhang, Ya‐nan; Nguyen, Linh V.; Warren‐Smith, Stephen C.; Zhao, Yong

doi:10.1109/tim.2022.3225034

Cited by 10 publications

(4 citation statements)

References 41 publications

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“…Fabry-Perot interferometers [101,102] and photonic crystal (PC) cavities [103] have been also used as photonic biosensors. Fabry-Perot cavities operate based on multi-beam interferences of electromagnetic waves passed through two highly reflective spaced surfaces.…”

Section: B Optical Biosensorsmentioning

confidence: 99%

“…Therefore, the changes in both the distance between reflective surfaces and the refractive index of the gap can be utilized to tune a Fabry-Perot resonator as an affinitybased biosensor. Accordingly, Fabry-Perot optical fibers can be appropriate choices for biosensing purposes in which applying the Vernier effect [101] or 2D materials (rGO nanosheets) to enhance energy transfer [102] can significantly improve the biosensor sensitivity. Additionally, photonic crystals are multidimensional dielectric cavities that can detect a variety of biological elements for disease diagnosis.…”

Section: B Optical Biosensorsmentioning

confidence: 99%

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Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia

Marvi,

Chen,

Sawan

2024

IEEE Rev. Biomed. Eng.

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Alzheimer's disease (AD) progressively impairs the memory and thinking skills of patients, resulting in a significant global economic and social burden each year. However, diagnosis of this neurodegenerative disorder can be challenging, particularly in the early stages of developing cognitive decline. Current clinical techniques are expensive, laborious, and invasive, which hinders comprehensive studies on Alzheimer's biomarkers and the development of efficient devices for Point-of-Care testing (POCT) applications. To address these limitations, researchers have been investigating various biosensing techniques. Unfortunately, these methods have not been commercialized due to several drawbacks, such as low efficiency, reproducibility, and the lack of accurate identification of AD markers. In this review, we present diverse promising hallmarks of Alzheimer's disease identified in various biofluids and body behaviors. Additionally, we thoroughly discuss different biosensing mechanisms and the associated challenges in disease diagnosis. In each context, we highlight the potential of realizing new biosensors to study various features of the disease, facilitating its early diagnosis in POCT. This comprehensive study, focusing on recent efforts for different aspects of the disease and representing promising opportunities, aims to conduct the future trend toward developing a new generation of compact multipurpose devices that can address the challenges in the early detection of AD.

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Section: B Optical Biosensorsmentioning

confidence: 99%

Section: B Optical Biosensorsmentioning

confidence: 99%

Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia

Marvi,

Chen,

Sawan

2024

IEEE Rev. Biomed. Eng.

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“…The impact of temperature within the range of 20 to 70 • C is minimal. This sensor exhibits fast response times, with a rise time of 80 ms and a recovery time of 70 ms. Reference [171] proposed a fiber optic sensor for DNA detection. Two sections of C-type optical fibers were inserted into an SMF to form two FP cavities.…”

Section: Biological or Medical Sensormentioning

confidence: 99%

A Review of Optical Fiber Sensing Technology Based on Thin Film and Fabry–Perot Cavity

Ma,

Peng,

Bai

et al. 2023

Coatings

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Fiber sensors possess characteristics such as compact structure, simplicity, electromagnetic interference resistance, and reusability, making them widely applicable in various practical engineering applications. Traditional fiber sensors based on different microstructures solely rely on the thermal expansion effect of silica material itself, limiting their usage primarily to temperature or pressure sensing. By employing thin film technology to form Fabry–Perot (FP) cavities on the end-face or inside the fiber, sensitivity to different physical quantities can be achieved using different materials, and this greatly expands the application range of fiber sensing. This paper provides a systematic introduction to the principle of FP cavity fiber optic sensors based on thin film technology and reviews the applications and development trends of this sensor in various measurement fields. Currently, there is a growing need for precise measurements in both scientific research and industrial production. This has led to an increase in the variety of structures and sensing materials used in fiber sensors. The thin film discussed in this paper, suitable for various types of sensing, not only applies to fiber optic FP cavity sensors but also contributes to the research and advancement of other types of fiber sensors.

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“…There are some detection principles of fiber-optic biosensors, such as localized surface plasmon resonance (LSPR) [ 8 ], interference [ 9 , 10 ], whispering gallery mode (WGM) [ 11 ], surface plasmon resonance (SPR) [ 12 , 13 ], etc. Among them, biosensors based on LSPR are particularly attractive.…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements of LSPR Fiber-Optic Biosensing: Combination Methods, Structure, and Prospects

Zhang

Zhou

et al. 2023

Biosensors

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Fiber-optic biosensors based on localized surface plasmon resonance (LSPR) have the advantages of great biocompatibility, label-free, strong stability, and real-time monitoring of various analytes. LSPR fiber-optic biosensors have attracted extensive research attention in the fields of environmental science, clinical medicine, disease diagnosis, and food safety. The latest development of LSPR fiber-optic biosensors in recent years has focused on the detection of clinical disease markers and the detection of various toxic substances in the environment and the progress of new sensitization mechanisms in LSPR fiber-optic sensors. Therefore, this paper reviews the LSPR fiber-optic sensors from the aspects of working principle, structure, and application fields in biosensors. According to the structure, the sensor can be divided into three categories: traditional ordinary optical fiber, special shape optical fiber, and specialty optical fiber. The advantages and disadvantages of existing and future LSPR fiber-optic biosensors are discussed in detail. Additionally, the prospect of future development of fiber-optic biosensors based on LSPR is addressed.

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Optical Fiber DNA Biosensor With Temperature Monitoring Based on Double Microcavities Fabry–Perot Interference and Vernier Combined Effect

Cited by 10 publications

References 41 publications

Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia

Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia

A Review of Optical Fiber Sensing Technology Based on Thin Film and Fabry–Perot Cavity

Recent Advancements of LSPR Fiber-Optic Biosensing: Combination Methods, Structure, and Prospects

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