Optical fibres and sensors for biomedical applications

Ding, M. D.; Brambilla, Gilberto

doi:10.1016/b978-0-85709-662-3.00003-8

Cited by 4 publications

(3 citation statements)

References 92 publications

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“…CO 2 and oxygen are two gases that are routinely measured in clinical settings [133]. OFS can be used to measure both of these gases via the simultaneous excitation of two fluorescent pH sensitive indicators with well-separated emission bands [134].…”

Section: Chemical Ofsmentioning

confidence: 99%

Biomedical application of optical fibre sensors

Correia

James

Lee

et al. 2018

J. Opt.

166

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Optical fibre sensors (OFS), as a result of their unique properties such as small size, no interference with electromagnetic radiation, high sensitivity and the ability to design multiplexed or distributed sensing systems, have found applications ranging from structural health monitoring to biomedical and point of care instrumentation. While the former represents the main commercial application for OFS, there is body of literature concerning the deployment of this versatile sensing platform in healthcare. This paper reviews the different types of OFS and their most recent applications in healthcare. It aims to help clinicians to better understand OFS technology and also provides an overview of the challenges involved in the deployment of developed technology in healthcare. Examples of the application of OFS in healthcare are discussed with particular emphasis on recently (2015–2017) published works to avoid replicating recent review papers. The majority of the work on the development of biomedical OFS stops at the laboratory stage and, with a few exceptions, is not explored in healthcare settings. OFSs have yet to fulfil their great potential in healthcare and methods of increasing the adoption of medical devices based on optical fibres are discussed. It is important to consider these factors early in the device development process for successful translation of the developed sensors to healthcare practice.

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Section: Chemical Ofsmentioning

confidence: 99%

Biomedical application of optical fibre sensors

Correia

James

Lee

et al. 2018

J. Opt.

166

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“…Changes in their concentration may indicate modifications in the metabolic pathways, including disruptions in protein and enzyme activity, gene activation or repression, and more. These alterations can be identified in biological samples using methods such as gas chromatography-mass spectrometry [1], electronic noses [2], optical fiber sensors (OFSs) [3], among others. Additionally, animals with highly developed olfactory capabilities can also detect these changes in biological samples [4].…”

Section: Introductionmentioning

confidence: 99%

Molecular imprinted polymer-coated optical fiber sensor for the quantification of 2-propanol

Leça,

Oliveira,

Ferreira

2024

Optical Sensing and Detection VIII

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The early detection of different diseases is crucial for their successful treatment. Existing literature has established distinct volatile organic compound (VOC) profiles in organic samples that are associated with different disease conditions. These identified profiles hold significant potential for the development of rapid, non-invasive, and cost-effective disease screening tools, meeting the essential criteria for effective diagnostic measures.2-propanol is a secondary alcohol that exhibits different associations with a variety of diseases across diverse organic samples. Notably, elevated levels of 2-propanol in urine samples have been linked to type II diabetes, whereas a decrease in its concentration is observed in cases of malignant biliary strictures. In feces, an increase in 2-propanol is associated with colorectal cancer. Furthermore, disturbances in 2-propanol levels in breath have been correlated with various types of cancers. These findings underscore the potential utility of 2-propanol as a biomarker for disease detection across multiple biological matrices.In this study, we propose a sensor that combines a multimode interference structure with a molecularly imprinted polymer (MIP) functionalization. The multimode sensor is created by fusion splicing a coreless fiber section to a single-mode fiber (SMF). For coating the coreless fiber (CSF), the dip coating technique was utilized, employing a MIP with 2-propanol as the template, and separately, the corresponding non-imprinted polymer (NIP). Our findings reveal that the MIP demonstrates specificity for 2-propanol in the gas phase, showing a sensitivity of 13 pm/wt.% 2-propanol. In contrast, the corresponding NIP lacks sensitivity to 2-propanol. This outcome emphasizes the potential of our proposed sensor design for the selective detection of 2-propanol, thereby highlighting its applicability in gas phase analyses.

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“…Actualmente, el desarrollo de los sensores de fibra óptica (SFO) está teniendo un crecimiento significativo en el diagnóstico médico y en la detección de parámetros físicos, biológicos y ambientales (Ding and Brambilla, 2015;Sharma and Gupta, 2018). Debido a que los SFO ofrecen varias ventajas sobre los sensores convencionales basados en cables conductores tales como: su inmunidad a la interferencia electromagnética, el tamaño pequeño, pasividad eléctrica, alta biocompatibilidad y sensibilidad, una respuesta rápida, la posibilidad de detección distribuida en un mismo hilo de fibra óptica y la capacidad de operar en ambientes peligrosos como zonas de altos voltajes (Botewad et al, 2018;Nurulain et al, 2017).…”

Section: Introductionunclassified

Modelado y simulación de un sensor de fibra óptica basado en la onda evanescente

Bermúdez

Lucho²,

Zamora‐Peredo³

et al. 2023

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El desarrollo y avance en los sensores de fibra óptica (SFO) se debe a las ventajas únicas que poseen sobre los sensores basados estado sólido, sus principales ventajas son: inmunidad a las interferencias electromagnéticas, alta sensibilidad y posibilidad de sensado distribuido, por lo cual han encontrado aplicaciones en una gran variedad de campos debido a que la mayoría de las variables físicas y químicas pueden ser monitoreadas con los SFO. Uno de los principales mecanismos de detección es la absorción de ondas evanescentes, por lo que es importante conocer los parámetros que determinan el comportamiento de esta en los SFO. En este trabajo se describe el modelado matemático y simulación para determinar los parámetros como la absorción de la onda evanescente y la profundidad de penetración. De acuerdo con los resultados numéricos se obtuvo una absorción de la onda evanescente de 0.2x10-3 ua, y profundidad de penetración de 2 µm.

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Optical fibres and sensors for biomedical applications

Cited by 4 publications

References 92 publications

Biomedical application of optical fibre sensors

Biomedical application of optical fibre sensors

Molecular imprinted polymer-coated optical fiber sensor for the quantification of 2-propanol

Modelado y simulación de un sensor de fibra óptica basado en la onda evanescente

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