Optical Fluorescence and Its Application to an Intravascular Blood Gas Monitoring System

Gehrich, John L.; Lübbers, D. W.; Opitz, N.; Hansmann, Douglas R.; Miller, William; Tusa, James K.; Yafuso, Maseo

doi:10.1109/tbme.1986.325886

Cited by 227 publications

(76 citation statements)

References 39 publications

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“…The idea was that these sensors would reside in a patient's artery for two or three days to provide real-time data on the blood oxygen and carbon dioxide levels as well as blood pH. 75 Despite substantial progress in developing sensors and the associated measurement electro- nics, two major stumbling blocks were encountered: blood clots and blood platelets, and proteins deposit on foreign surfaces. 76±78 Consequently, although the sensors were biocompatible, they were not, and still are not, blood compatible.…”

Section: Discussionmentioning

confidence: 99%

Ionic optodes: role in fiber optic chemical sensor technology

Langry¹,

Rambabu²

1999

J. Chem. Technol. Biotechnol.

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Fiber optic chemical sensors and solid state devices are two versatile sensing technologies for detecting analytes in a host of media. Obvious differences distinguish these technologies: however, they share signi®cant features and issues related to analyte identi®cation and selectivity. This report reviews transduction schemes used in ®ber optic sensors for monitoring aqueous ionic species and examines some critical concerns that may hinder commercial acceptance.

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Section: Discussionmentioning

confidence: 99%

Ionic optodes: role in fiber optic chemical sensor technology

Langry¹,

Rambabu²

1999

J. Chem. Technol. Biotechnol.

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“…Optical sensors have been widely used as gas sensors in many applications due to their response which could be measured precisely [16][17][18]. These sensors are based on a light source that excites the volatile molecules, and the signal can be measured in the resulting absorbance, reflectance, fluorescence, or chemiluminescence.…”

Section: Optical Sensorsmentioning

confidence: 99%

Electronic Nose and Electronic Tongue

Zou

Wan

Zhang

et al. 2015

Bioinspired Smell and Taste Sensors

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“…Additionally, researchers have developed various optical fiber sensors for pH, blood pressure, and some gas concentrations such as oxygen and CO [19][20][21], which are important for a correct and effective diagnosis of a disease. Furthermore, by exploiting the interaction of antibodies with antigens, an antibody optical fiber sensor has been realized by attaching a specific antibody on a fiber end with surface modification techniques.…”

Section: Biomedical Application Of Optical Fiber Sensorsmentioning

confidence: 99%

Microgap Structured Optical Sensor for Fast Label-Free DNA Detection

Wang

Cooper

Wang

2008

J. Lightwave Technol.

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DNA detection technology has developed rapidly due to its extensive application in clinical diagnostics, bioengineering, environmental monitoring, and food science areas.Currently developed methods such as surface Plasmon resonance (SPR) methods, fluorescent dye labeled methods and electrochemical methods, usually have the problems of bulky size, high equipment cost and time-consuming algorithms, so limiting their application for in vivo detection. In this work, an intrinsic Fabry-Perot interferometric (IFPI) based DNA sensor is presented with the intrinsic advantages of small size, low cost and corrosion-tolerance. This sensor has experimentally demonstrated its high sensitivity and selectivity.In theory, DNA detection is realized by interrogating the sensor's optical cavity length variation resulting from hybridization event. First, a microgap structure based IFPI sensor is fabricated with simple etching and splicing technology. Subsequently, considering the sugar phosphate backbone of DNA, layer-by-layer electrostatic self-assembly technique is adopted to attach the single strand capture DNA to the sensor endface. When the target DNA strand binds to the single-stranded DNA successfully, the optical cavity length of sensor will be increased. Finally, by demodulating the sensor spectrum, DNA hybridization event can be judged qualitatively.This sensor can realize DNA detection without attached label, which save the experiment expense and time. Also the hybridization detection is finished within a few minutes.This quick response feature makes it more attractive in diagnose application. Since the iii sensitivity and specificity are the most widely used statistics to describe a diagnostic test, so these characteristics are used to evaluate this biosensor. Experimental results demonstrate that this sensor has a sensitivity of 6nmol/ml and can identify a 2 bp mismatch. Since this sensor is optical fiber based, it has robust structure and small size ( 125μm ). If extra etching process is applied to the sensor, the size can be further reduced. This promises the sensor potential application of in-cell detection. Further investigation can be focused on the nanofabrication of this DNA sensor, and this is very meaningful topic not only for diagnostic test but also in many other applications such as food industry, environment monitoring.iv Acknowledgement

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Optical Fluorescence and Its Application to an Intravascular Blood Gas Monitoring System

Cited by 227 publications

References 39 publications

Ionic optodes: role in fiber optic chemical sensor technology

Ionic optodes: role in fiber optic chemical sensor technology

Electronic Nose and Electronic Tongue

Microgap Structured Optical Sensor for Fast Label-Free DNA Detection

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