Optical Imaging of Epileptic Seizures

Tsytsarev, Vassiliy

doi:10.1007/978-981-16-5540-1_124

Cited by 1 publication

(7 citation statements)

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“…16 Currently, a large number of them are widely used when working with in vivo epileptic models, and the number of technological solutions used in this case is growing. 16,20 The development of neurophotonics has had an impact not only on the methods of using epileptic models but also on the models themselves. 21…”

Section: Key Pointsmentioning

confidence: 99%

“…Optogenetic inhibition of neural activity has been successfully employed to suppress epileptic seizures in different animal models. 16,[81][82][83][84][85] Many types of focal epileptic activity arise as a result of a in the balance of excitation and inhibition, which is often associated with a deficient efficiency of the GABAergic system. In epileptic models, experimental reduction of inhibition by blocking GABAergic neurotransmission induces epileptiform activity.…”

Section: For Control Of Epileptiform Activitymentioning

confidence: 99%

“…Optical techniques have revolutionized many directions of neurobiological research 2,7 . Their introduction has radically changed the development and investigation of epileptic models 16 . After the development of optical imaging of intrinsic signals, the process of creating new optical imaging methods has developed exponentially 16–19 .…”

Section: Introductionmentioning

confidence: 99%

“…2,7 Their introduction has radically changed the development and investigation of epileptic models. 16 After the development of optical imaging of intrinsic signals, the process of creating new optical imaging methods has developed exponentially. [16][17][18][19] Currently, a large number of them are widely used when working with in vivo epileptic models, and the number of neurophotonic technological solutions used in this case is growing.…”

mentioning

confidence: 99%

“…16 After the development of optical imaging of intrinsic signals, the process of creating new optical imaging methods has developed exponentially. [16][17][18][19] Currently, a large number of them are widely used when working with in vivo epileptic models, and the number of neurophotonic technological solutions used in this case is growing. 20 The development of neurophotonics had a significant impact not only on the methods of using epileptic models but also on the models themselves.…”

mentioning

confidence: 99%

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Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations

Tsytsarev,

Sopova,

Leonova

et al. 2024

Epilepsia

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Neurophotonic technology is a rapidly growing group of techniques that are based on the interactions of light with natural or genetically modified cells of the neural system. New optical technologies make it possible to considerably extend the tools of neurophysiological research, from the visualization of functional activity changes to control of brain tissue excitability. This opens new perspectives for studying the mechanisms underlying the development of human neurological diseases. Epilepsy is one of the most common brain disorders; it is characterized by recurrent seizures and affects >1% of the world's population. However, how seizures occur, spread, and terminate in a healthy brain is still unclear. Therefore, it is extremely important to develop appropriate models to accurately explore the causal relationship of epileptic activity. The use of neurophotonic technologies in epilepsy research falls into two broad categories: the visualization of neural epileptic activity, and the direct optical influence on neurons to induce or suppress epileptic activity. An optogenetic variant of the classical kindling model of epileptic seizures, in which activatable cells are genetically defined, is called optokindling. Research is also underway concerning the application of neurophotonic techniques for suppressing epileptic activity, aiming to bring these methods into clinical practice. This review aims to systematize and describe new approaches that use combinations of different neurophotonic methods to work with in vivo models of epilepsy. These approaches overcome many of the shortcomings associated with classical animal models of epilepsy and thus increase the effectiveness of developing new diagnostic methods and antiepileptic therapy.

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Section: Key Pointsmentioning

confidence: 99%