2018
DOI: 10.1101/285908
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Optical Imaging of Metabolic Dynamics in Animals

Abstract: Direct visualization of metabolic dynamics in living tissues with high spatial and temporal resolution is essential to understanding many biological processes. Here we introduce a platform that combines deuterium oxide (D2O) probing with stimulated Raman scattering microscopy (DO-SRS) to image in situ metabolic activities. Enzymatic incorporation of D2O-derived deuterium into macromolecules generates carbondeuterium (C-D) bonds, which track biosynthesis in tissues and can be imaged by SRS in situ. Within the b… Show more

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