Chiral symmetry provides the symmetry protection for a large class of topological edge states. It exists in non-Hermitian systems as well, and the same anti-commutation relation between the Hamiltonian and a linear chiral operator, i.e., {H, Π} = 0, now warrants a symmetric spectrum about the origin of the complex energy plane. Here we show two general approaches to construct chiral symmetry in non-Hermitian systems, with an emphasis on lattices with detuned on-site potentials that can vary in both their real and imaginary parts. One approach relies on the simultaneous satisfaction of both non-Hermitian particle-hole symmetry and non-Hermitian bosonic anti-linear symmetry, while the other utilizes the Clifford algebra satisfied by the Dirac matrices. We also distinguish non-Hermitian chiral symmetry from pseudo-chirality, with the latter defined by ηH T η −1 = −H and belonging to a broadened definition of symmetry that maps between the left and right eigenspaces of a non-Hermitian Hamiltonian.