Optical methods and image processing as a quantitative tool in photodynamic therapy: a proof of concept

Rivera-Fernández, Josué D.; Roa-Tort, Karen; Rosa, J. de la; Valor, A.; Stolik, S.; Fabila-Bustos, Diego A.; Guzmán, Carolina; Escobedo, Galileo

doi:10.1109/conielecomp.2019.8673128

Cited by 1 publication

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One prerequisite to realize precise illumination during V-PDT is to quantitatively analyze the V-PDT efficacy, including the lesion appearance and severity at different V-PDT stages, so as to accurately estimate the required light dosage in the following treatment. In previous study, Euclidean distance and two-dimensional correlation coefficient calculated based on lesion images were employed to evaluate the V-PDT efficiency on PWS, and results show that a satisfactory V-PDT efficiency leads to a larger Euclidean distance and a smaller two-dimensional correlation coefficient, in comparison with a case with less effective V-PDT [6][7] [8][9] [10]. However, by these two evaluation methods, only very little difference in values can be observed for distinct V-PDT efficacy, which shows a limited sensitivity of the mentioned methods leading to difficulties in V-PDT efficacy evaluation, specifically in cases with small efficacy differences.…”

Section: Introductionmentioning

confidence: 99%

High-sensitivity efficacy evaluation methods for vascular-targeted photodynamic therapy of port-wine stains

Xi,

Lin,

Qiu

et al. 2023

6th Optics Young Scientist Summit (OYSS 2023)

View full text Add to dashboard Cite

Vascular-targeted photodynamic therapy (V-PDT) has become an important therapeutic method for blood vessel-related diseases such as port-wine stains (PWSs). To achieve more precise V-PDT, quantitative evaluation of V-PDT efficiency appears to be an essential prerequisite. In previous study, methods of Euclidean distance and two-dimensional correlation coefficient, which were calculated based on PWS lesion images, had been employed to evaluate the efficacy of V-PDT. However, results of the mentioned methods show little difference for different V-PDT efficiency, which indicates a limited sensitivity leading to difficulties in V-PDT efficacy evaluation. In this work, evaluation methods with higher sensitivity, including pixel count change, average gray value change, and entropy change which were analyzed based on lesion images before and after V-PDT, were developed for V-PDT efficiency evaluation on PWS. These evaluation methods reveal V-PDT effect from aspects of lesion area, skin color, and skin texture. In addition, relative difference rates of all methods were analyzed for sensitivity comparison. The results indicate that changes of pixel number, average grayscale value, and entropy well reflect differences in V-PDT efficacy, and exhibit much higher sensitivity in comparison with that of Euclidean distance and two-dimensional correlation coefficient, confirming themselves a promising quantitative evaluation method for V-PDT efficacy.

show abstract

Section: Introductionmentioning

confidence: 99%