Optical microprobe for blood clot detection

Gatto, Romano; D'Amico, E.; Mantulin, William W.; Gratton, E; Charbel, Fady T.

doi:10.1364/bio.2006.me47

Cited by 3 publications

(3 citation statements)

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“…The turbidity detection method involves mixing the plasma specimen and coagulation reagent, and then measuring changes in the transmitted light or the scattered light during the process of the plasma coagulating. 7 Small changes in the transmitted or scattered light can be detected even with a low level of fibrin, 8 and it is hence free from the shortcoming of the viscosity detection method. Nevertheless, few in vitro tests that are also used in clinical practice are performed on blood samples.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography to investigate optical properties of blood during coagulation

Lin

2011

J. Biomed. Opt.

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Abstract. This study investigates the optical properties of human blood during the coagulation process under statics using optical coherence tomography (OCT). OCT signal slope (OCTSS) and 1/e light penetration depth (d 1/e ) were obtained from the profiles of reflectance versus depth. Results showed that both OCTSS and d 1/e were able to sensitively differentiate various stages of blood properties during coagulating. After 1 h clotting, OCTSS decreased by 47.0%, 15.0%, 13.7%, and 8.5% and d 1/e increased by 34.7%, 29.4%, 24.3%, and 22.9% for the blood samples at HCT of 25%, 35%, 45%, and 55%, respectively. The slope of d 1/e versus time (S r , ×10 − 4 mm/s), associated with clot formation rate decreased from 6.0 ± 0.3, 3.7 ± 0.5 to 2.3 ± 0.4 with the increasing of HCT from 35%, 45%, to 55%. The clotting time (t c ) from the d 1/e evolution curves was estimated to be 1969 ± 92 s, 375 ± 12 s, 455 ± 11 s, and 865 ± 47 s for the blood of 25%, 35%, 45%, and 55%. This study demonstrates that the parameters (t c and S r ) from the variations in d 1/e had better sensitivity and smaller standard deviation. Furthermore, blood hematocrit affecting backscattering properties of blood during coagulation was capable of being discerned by OCT parameters. It is concluded that OCT is a potential technique to quantify and follow the liquid-gel transition of blood during clotting. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography to investigate optical properties of blood during coagulation

Lin

2011

J. Biomed. Opt.

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“…As stated before, due to most of the conventional methods being applied in plasma coagulation 24,25 and whole blood coagulation of static condition, 8,19,36,37 it is not feasible to compare the OCT results to the clotting times estimated with the traditional techniques, such as a conventional prothrombin time test. Compared to the traditional clotting time measurements, the OCT technology has the advantage of measuring flowing whole blood rather than plasma under static state and getting rid of the restriction of media (e.g., water).…”

Section: Discussionmentioning

confidence: 99%

“…A lot of previous studies on the detection of blood coagulation have been performed, in which techniques have been developed or applied including the use of mechanical impedance, electromagnetism, photometry, and acoustics. [2][3][4][5] Most of these available modalities are not appropriate for continuous and dynamic measurements and monitoring. In addition, the vast majority of existing methods for testing blood coagulation in vitro is performed under "no flow" conditions.…”

Section: Introductionmentioning

confidence: 99%

Monitoring the blood coagulation process under various flow conditions with optical coherence tomography

Geng

Teng

2014

J. Biomed. Opt

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Our previous work demonstrated that an optical coherence tomography (OCT) technique was able to characterize the whole blood coagulation process. The 1/e light penetration depth (d(1/e)) derived from the profiles of reflectance versus depth was developed for detecting the whole blood coagulation process in static state. To consider the effect of blood flow, in the present study, d(1/e) versus time from the coagulating porcine blood circulated in a mock flow loop with various steady laminar flows at mean flow speed in the range from 5 to 25 mm/s. The variation of d(1/e) was used to represent the change of blood properties during coagulation in different hematocrits (HCT) ranging from 25% to 55%, velocities from 5 to 25 mm/s, and tubing sizes from 0.9 to 2 mm. The results showed that there were positive correlations between coagulation time (t(c)) and HCT, velocity, and tubing size, respectively. In addition, the coagulation rate (S(r)) was decreased with the increase of HCT, velocity, and tubing size. This study testified that HCT, flow velocity, and tubing size were substantial factors affecting the backscattering properties during flowing blood coagulation. Furthermore, OCT has the potential to represent the process of flowing blood coagulation with proper parameters.

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Chromatic Properties of Blood During Coagulation

Razavi¹,

Arbabian

2019

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Optical microprobe for blood clot detection

Abstract: Abstract:One of the mayor complications during vascular surgery is the formation of blood clot. We tested an animal model and assembled a prototype device that shows the blood clot signature spectrum and its temporary growth.

Cited by 3 publications

References 10 publications

Optical coherence tomography to investigate optical properties of blood during coagulation

Optical coherence tomography to investigate optical properties of blood during coagulation

Monitoring the blood coagulation process under various flow conditions with optical coherence tomography

Chromatic Properties of Blood During Coagulation

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