This paper systematically investigated the impact mechanisms of proton irradiation, atomic oxygen irradiation, and space debris collision, both individually and in combination, on the laser damage threshold and damage evolution characteristics of HfO2/SiO2 triple-band high-reflection films and fused silica substrates using a simulated near-earth space radiation experimental system. For the high-reflection film samples, the damage thresholds decreased by 15.38%, 13.12%, and 46.80% after proton, atomic oxygen, and simulated space debris (Penetration) irradiation, respectively. The coupling irradiation of the first two factors resulted in a decrease of 26.93%, while the combined effect of all