Optical neuromodulation at all scales: from nanomaterials to wireless optoelectronics and integrated systems

Karatum, Onuralp; Gwak, Min-Jun; Hyun, Junghun; Önal, Asım; Koirala, Gyan Raj; Kim, Tae‐il; Nizamoğlu, Sedat

doi:10.1039/d2cs01020h

Cited by 22 publications

(11 citation statements)

References 226 publications

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“…A narrow size distribution is necessary to ensure that the encapsulated biomolecules exhibit similar release profiles, providing better control over drug delivery or other therapeutic strategies. [45,46] The microfluidic emulsification process employed in this study enabled the production of monodispersed honeycomb-structured microparticles with a low coefficient of variation (CV) in size, as shown in Figure 6c (see Figure S3, Supporting Information for detailed size distributions). The monodispersity of the microparticles is attributed to the precise control of the droplet generation process in microfluidic channels, which allows the production of particles with minimal size variation.…”

Section: Plga Microparticles With Multiple Microchambers Fabricated V...mentioning

confidence: 99%

Multichamber PLGA Microparticles with Enhanced Monodispersity and Encapsulation Efficiency Fabricated by a Batch‐Microfluidic Hybrid Approach

Choi,

Kang,

Choi

et al. 2023

Advanced NanoBiomed Research

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Microparticles with multiple internal chambers hold great promise as drug delivery systems due to their ability to sustain the release of drugs with short half‐lives. However, conventional batch methods used for their fabrication have limitations in terms of encapsulation efficiency and particle size distributions, while microfluidic methods suffer from low production efficiency. Herein, a batch‐microfluidic hybrid method is presented for fabricating poly(DL‐lactic‐co‐glycolic acid) (PLGA) polymeric microparticles with uniformly distributed, multiple inner microchambers. A scalable batch method is utilized for primary water‐in‐oil (W/O) emulsions, combined with a precise microfluidic approach for generating controlled secondary emulsions. This approach results in highly uniform PLGA microparticles with tunable size and improved encapsulation efficiency. Additionally, the effect of polydopamine‐based surface hydrophilic modification of microfluidic channels on drug encapsulation efficiency is investigated, achieving an efficiency of approximately 85%. The prepared multichamber PLGA microparticles exhibit an extended‐release profile without initial burst release, demonstrating their potential for sustained drug delivery in various biomedical applications.

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Section: Plga Microparticles With Multiple Microchambers Fabricated V...mentioning

confidence: 99%

Multichamber PLGA Microparticles with Enhanced Monodispersity and Encapsulation Efficiency Fabricated by a Batch‐Microfluidic Hybrid Approach

Choi,

Kang,

Choi

et al. 2023

Advanced NanoBiomed Research

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“…The prerequisite of optogenetic-modulated cellular functions or physiological processes is the activation of the corresponding proteins upon light stimulations. Conventionally employed opsins in optogenetics are always responsive to visible light, which can only achieve superficial penetration, and cannot enter deep tissues for optogenetic studies, due to its easily scattering, reflecting and absorption by biological molecules or tissues. , Recently, the Deisseroth group developed a red-responsive opsin, ChRmine, to conducted noninvasive deep tissue penetration optogenetics at a depth of 7 mm . However, many other intracellular pathway modulations still lack effective red light-responsive opsins.…”

Section: Introductionmentioning

confidence: 99%

Nano-optogenetics for Disease Therapies

Lu,

Sun,

Liang

et al. 2024

ACS Nano

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Optogenetic, known as the method of 21 centuries, combines optic and genetic engineering to precisely control photosensitive proteins for manipulation of a broad range of cellular functions, such as flux of ions, protein oligomerization and dissociation, cellular intercommunication, and so on. In this technique, light is conventionally delivered to targeted cells through optical fibers or micro light-emitting diodes, always suffering from high invasiveness, wide-field illumination facula, strong absorption, and scattering by nontargeted endogenous substance. Light-transducing nanomaterials with advantages of high spatiotemporal resolution, abundant wireless-excitation manners, and easy functionalization for recognition of specific cells, recently have been widely explored in the field of optogenetics; however, there remain a few challenges to restrain its clinical applications. This review summarized recent progress on light-responsive genetically encoded proteins and the myriad of activation strategies by use of light-transducing nanomaterials and their disease-treatment applications, which is expected for sparking helpful thought to push forward its preclinical and translational uses.

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“…Furthermore, their nanoscale feature enables efficient transport to the target tissue without phagocytosis . These characteristics make them a versatile platform for controlled and targeted delivery in various applications, including cancer therapy, gene delivery, vaccine development, functional food ingredients, and biosensors. , Currently, nanoliposomes and lipid-based nanoparticles rank as some of the most prevalent forms of nanomedicines, accounting for 33% of those in the market or undergoing clinical trials. − …”

Section: Introductionmentioning

confidence: 99%

Bromelain-Decorated Nanoscale Liposomes for Mucus Permeation and Intestinal Absorption in Oral Drug Delivery

Park,

Choi,

Kang

et al. 2023

ACS Appl. Nano Mater.

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Nanoscale liposomes are widely recognized as promising drug delivery materials; yet, their utilization in oral drug delivery has been hindered by their limited ability to efficiently penetrate the intestinal mucus layer. Herein, we present an approach to enhance oral drug delivery and improve the mucus penetration capability of liposomes by conjugating bromelain, a mucolytic enzyme derived from pineapple stems, to the liposome membrane (Bro-Lip). With an optimized bromelain payload of 11.1 nmol/mg, we achieved an impressive 47.8% conjugation efficiency while retaining 77.5% of the proteolytic activity post conjugation. Physicochemical analysis revealed that Bro-Lip measured 152.8 nm in size with a ζ potential of −2.3 mV. Notably, Bro-Lip exhibited a significantly enhanced capacity to penetrate the porcine mucus layer, demonstrating a 2.87-fold improvement compared with bare liposomes. Furthermore, we assessed the transcellular permeability of Bro-Lips using Caco-2 and Caco-2/HT29 coculture models, revealing substantial enhancements in permeability compared to unmodified liposomes. Specifically, in Caco-2 cell monolayers, mucus permeability increased by 3.80-fold, while in Caco-2/HT29 cocultures, it rose by 2.25-fold. Additionally, Bro-Lip demonstrated an improved cellular uptake in Caco-2 cells. These findings highlight the potential of Bro-Lip as an effective oral delivery system by enhancing mucus permeation and cell membrane permeation.

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Optical neuromodulation at all scales: from nanomaterials to wireless optoelectronics and integrated systems

Abstract: This review summarizes optical nanomaterials, devices, and systems for neuromodulation. We describe their structures, working principles and bioelectronic applications with challenges and prospects.

Cited by 22 publications

References 226 publications

Multichamber PLGA Microparticles with Enhanced Monodispersity and Encapsulation Efficiency Fabricated by a Batch‐Microfluidic Hybrid Approach

Multichamber PLGA Microparticles with Enhanced Monodispersity and Encapsulation Efficiency Fabricated by a Batch‐Microfluidic Hybrid Approach

Nano-optogenetics for Disease Therapies

Bromelain-Decorated Nanoscale Liposomes for Mucus Permeation and Intestinal Absorption in Oral Drug Delivery

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