Strong amplification in integrated photonics is one of the most desired optical functionalities for computing 1 , communications 2 , sensing 3 , and quantum information processing 4 .Semiconductor gain 5,6 and cubic nonlinearities, such as four-wave mixing 7,8 and stimulated Raman and Brillouin scattering 9,10 , have been among the most studied amplification mechanisms on chip.Alternatively, material platforms with strong quadratic nonlinearities promise numerous advantages with respect to gain and bandwidth 11 , among which nanophotonic lithium niobate is one of the most promising candidates [12][13][14][15] . Here, we combine quasi-phase matching with dispersion engineering in nanophotonic lithium niobate waveguides and achieve intense optical parametric amplification. We measure a broadband phasesensitive amplification larger than 45 dB/cm in a 2.5-mm-long waveguide. We further confirm high gain operation in the degenerate and nondegenerate regimes by amplifying vacuum fluctuations to macroscopic levels in a 6-mm-long waveguide, with gains exceeding 100 dB/cm over 600 nm of bandwidth around 2 µm. Our results unlock new possibilities for on-chip few-cycle nonlinear optics, mid-infrared photonics, and quantum photonics.