Optical performance of hydrophobic acrylic intraocular lenses with surface light scattering

Ogura, Yuichiro; Ong, Marcia; Akinay, Ali E.; Carson, Dennis; Pei, Ron; Karakelle, Mutlu

doi:10.1016/j.jcrs.2013.05.051

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…Morphologically they correspond to microvacuoles within the hydrophobic IOL material. Although glistenings seem to reduce contrast sensitivity, a reduction of visual acuity is rare [ 23 – 26 ]. Aside from calcifications, other alterations of the IOL material have been described, such as IOL schisis, which is caused by the formation of a gap within the IOL material and may also reduce contrast sensitivity [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment

et al. 2017

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BackgroundLaboratory analysis and optical quality assessment of explanted hydrophilic intraocular lenses (IOLs) with clinically significant opacification after posterior lamellar keratoplasty (DMEK and DSAEK).MethodsThirteen opacified IOLs after posterior lamellar keratoplasty, 8 after descemet stripping automated endothelial keratoplasty (DSAEK), 3 after descemet membrane endothelial keratoplasty (DMEK) and 2 after both DSAEK and DMEK were analysed in our laboratory. Analyses included optical bench assessment for optical quality, light microscopy, scanning electron microscopy (SEM) and energy dispersive X-Ray spectroscopy (EDS).ResultsIn all IOLs the opacification was caused by a thin layer of calciumphosphate that had accumulated underneath the anterior optical surface of the IOLs in the area spared by the pupil/anterior capsulorhexis. The calcifications lead to a significant deterioration of the modulation transfer function across all spatial frequencies of the affected IOLs.ConclusionsThe instillation of exogenous material such as air or gas into the anterior chamber increases the risk for opacification of hydrophilic IOLs irrespective of the manufacturer or the exact composition of the hydrophilic lens material. It is recommended to avoid the use of hydrophilic acrylic IOLs in patients with endothelial dystrophy that will likely require procedures involving the intracameral instillation of air or gas, such as DMEK or DS(A)EK.

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Section: Discussionmentioning

confidence: 99%

Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment

et al. 2017

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“…27 Staining with Coomassie blue G-250 can confirm protein removal, and, if required, proteins may be eliminated with treatment with a mixture of enzymes (subtilisin A and trypsin), a chelator (ethylenediaminetetraacetic acid), and with a solution of 0.6% sodium hypochlorite in phosphate-buffered saline; in this case, the residual stain should be removed by treating the IOL with a 0.6% sodium hypochlorite solution and then rinsing in distilled deionized water. [55][56][57] As glistening and SSNGS are temper- Gross photograph of the explanted lens in the dry state (320). (B) Light photomicrograph of the dry lens (3400).…”

Section: Methods For Iol Evaluationmentioning

confidence: 99%

Microscopic Characteristics of Late Intraocular Lens Opacifications

Kanclerz¹,

Yildirim

Khoramnia

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— The increases in overall life expectancy and in lens surgeries performed on younger patients have resulted in a significant increase in the anticipated duration of artificial intraocular lenses (IOLs) in the eye. Thus, the physicochemical properties of the IOL become a critical issue, and several types of postoperative IOL opacifications have been reported. Objective.— To describe the microscopic characteristics of opacified IOLs. Glistenings and subsurface nanoglistenings are fluid-related phenomena developing mainly in hydrophobic acrylic IOLs and are associated with aqueous influx into the IOL matrix. Calcification presents in hydrophilic acrylic or silicone IOLs as deposits of hydroxyapatite or other phases of calcium. Snowflake degeneration is less common, and it manifests in older polymethyl methacrylate IOLs. Data Sources.— PubMed and ScienceDirect databases were searched for the following keywords: intraocular lens, IOL, cataract surgery, phacoemulsification, opacification, glistening, subsurface nanoglistenings, calcification, snowflake degeneration. English-language articles published up to October 15, 2019 were included in the study. The manuscript contains mainly a literature review; however, it was supplemented with original investigations from the David J. Apple International Laboratory for Ocular Pathology Conclusions.— Glistenings and subsurface nanoglistenings should be evaluated in hydrated state and at room temperature; they manifest as microvacuoles sized from 1.0 to greater than 25.0 μm and less than 200 nm, respectively. Calcification deposits are situated on or underneath the surface of the IOL and can be stained with a 1% alizarin red solution or with the von Kossa method. Snowflake degeneration manifests as “particles” or “crystals,” causing whitish IOL discoloration. Scanning electron microscopy or energy dispersive X-ray spectroscopy may improve the diagnostic accuracy.

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“…The coexistence of these two factors, i.e., the high level of glistening and protein adsorption, slightly affected the light transmittance of the examined IOLs, which as a result of extreme incubation test conditions, decreased only by about 10.0%. However, this should not negatively impact the overall quality of vision because the decrease was consistent throughout the visible range [32,33]. The presence of the albumin layer on the surface of hydrophobic IOLs reduced visible light transmission compared to non-degraded IOLs, mainly for Tecnis® and Acry-Sof® IQ SN60WF (Fig.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of long-term changes in physicochemical properties of hydrophobic intraocular lenses in a laboratory model

et al. 2022

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially IntroductIonA cataract is a common disease among people over 60 (except for its congenital form that occurs at birth), which is treated surgically. The direct cause of the disease is opacification of the lens leading to its damage to the eye, and statistics claim that more

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Optical performance of hydrophobic acrylic intraocular lenses with surface light scattering

Abstract: Surface light scattering of explanted IOLs did not affect image resolution or MTF values. Although light transmission was slightly decreased, the magnitude appeared to be inconsequential for optical performance.

Cited by 13 publications

References 17 publications

Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment

Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment

Microscopic Characteristics of Late Intraocular Lens Opacifications

Evaluation of long-term changes in physicochemical properties of hydrophobic intraocular lenses in a laboratory model

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