Optical properties and toxicity of undoped and Mn-doped ZnS semiconductor nanoparticles synthesized through the aqueous route

Labiadh, Houcine; Sellami, Badreddine; Khazri, Abdelhafidh; Saidani, Wiem; Saïd, Khemaïs

doi:10.1016/j.optmat.2016.12.011

Cited by 51 publications

(20 citation statements)

References 49 publications

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“…Lastly, we examined the tetrapod shaped Mn-doped QDs, which showed no significant toxicity, either in MPA-coated or micelle-encapsulated forms, at the same concentration as their cadmium-based counterparts. These results are consistent with previous findings in the literature, which used Mn-doped QDs in spherical shape that were prepared either by aqueous synthesis [24,29,30,[38][39][40][41] or ligand exchange [25,[42][43][44]. The combination of the Mn-doped QDs and the micelle platform may further reduce QD toxicity and provides an attractive candidate for future biological imaging studies.…”

Section: Discussionsupporting

confidence: 91%

“…For example, Liu et al reported that micelle encapsulated QDs showed considerably higher toxicity than their 3-mercaptopropionic acid coated counterparts in neuroblastoma (SH-SY5Y) cell lines [36]. In regard to the Mn-doped QDs, although several toxicity studies have been performed, these studies either used aqueous synthesis methodologies [24,29,30,[38][39][40][41], or applied the ligand exchange strategy [25,[42][43][44], and none of these QDs adopted a tetrapod morphology.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots

et al. 2021

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The optical properties of quantum dots (QD) make them excellent candidates for bioimaging, biosensing, and therapeutic applications. However, conventional QDs are comprised of heavy metals (e.g., cadmium) that pose toxicity challenges in biological systems. Synthesising QDs without heavy metals or introducing thick surface coatings, e.g., by encapsulation in micelles, can reduce toxicity. Here, we examined the toxicity of micelle encapsulated tetrapod-shaped Mn-doped ZnSe QDs, comparing them to 3-mercaptopropionic acid (MPA)-capped Mn-doped ZnSe QDs prepared by ligand exchange and commercial CdSe/ZnS QD systems that were either capped with MPA or encapsulated in micelles. HepG2 cell treatment with MPA-coated CdSe/ZnS QDs resulted in a dose-dependent reduction of viability (MTT assay, treatment at 0–25 μg/mL). Surprisingly, no reactive oxygen species (ROS) or apoptotic signaling was observed, despite evidence of apoptotic behavior in flow cytometry. CdSe/ZnS QD micelles showed minimal toxicity at doses up to 25 μg/mL, suggesting that thicker protective polymer layers reduce cytotoxicity. Despite their shape, neither MPA- nor micelle-coated Mn-doped ZnSe QDs displayed a statistically significant toxicity response over the doses investigated, suggesting these materials as good candidates for bioimaging applications.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots

et al. 2021

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“…However, the toxic effects of cadmium QDs restricted their application in biological and environmental detection [27]. Fortunately, ZnS QDs having low toxicity, wide band gap energy (3.7 eV) [17] for various dopants and small exciton Bohr radius is the perfect host material to replace Cd [28]. Mndoped ZnS QD causes the red-shift of the initial emission wavelength of ZnS quantum dots from 450 nm to 590 nm [29], where the redshift is triggered by the variation of transition from 4T1 to 6A1 in ZnS crystal stimulated by Mn ions [30].…”

Section: Introductionmentioning

confidence: 99%

Mn-DOPPED ZnS QUANTUM DOTS AS SENSITIVE SENSOR FOR DETERMINATION OF CIPROFLOXACIN IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

Jan

Ara

Ali

et al. 2021

J. Chil. Chem. Soc.

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A simple and fast spectrofluorimetric method for determination of ciprofloxacin based on its quenching effect on the fluorescence intensity of colloidal water soluble TGA caped, Mn doped ZnS quantum dots (QDs) has been described. The QDs having characteristic fluorescence spectra with maximum excitation at 315 nm followed by an emission peak at 632 nm were characterized using Energy Dispersive X-Ray and X-ray Diffraction techniques. The effect of various parameters such as concentration of QDs, time, pH, common excipients and metal ions on the quenching phenomenon was investigated. Fluorescence quenching was found to be maximum with 10 µg mL -1 of QDs at pH 8 and fluorescence intensity was observed to be constant upto 45 min. The Stern-Volmer calibration plot of F 0 /F as a function of ciprofloxacin concentration was found to be linear in the range of 0.5-10 µg mL -1 with r² = 0.993. Under optimal experimental conditions, the method was found to be interference free. The percent relative standard deviation of the proposed method, calculated against method blank, was found to be 1.10%. The limit of detection (LOD) and the limit of quantitation (LOQ) for ciprofloxacin (signal to noise ratio 3:1 for LOD and 10:1 for LOQ) were calculated to be 0.15 and 0.50 μg mL -1 respectively. Average percent recoveries (±SD) obtained for spiked commercial formulations; ciprol and ciproquine, and serum and urine samples were found to be in the range of 92.2±1.8% to 99.5±1.5%, 90.5±1.2% to 96.7±1.4% and 94.0±1.2% to 98.5±1.4% respectively. The data evidently proves the potential of the proposed sensor QDs in biological analysis.

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“…The addition of transition metal (TM) ions made an extraordinary variation in optical, structural, electrical and transition probabilities in the Zn-S lattice [6,7]. Within the different TMs, Mn was chosen as the rst doping material since it improves the emission properties, enhances the electrical, microstructural and optical characters and also possesses better photo and thermal stability [8]. Chandrasekar et al [9] discussed the variation in Urbach energy, Stokes's shift and steepness values in Mn added ZnS synthesized by co-precipitation technique.…”

Section: Introductionmentioning

confidence: 99%

Band Gap Tailoring, Size Modulation and Photoluminescence Properties of Mn/Cu doped ZnS Nanostructures

Paul¹,

Muthukumaran²

2021

Preprint

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ZnS, Mn added ZnS (Zn0.97Mn0.03S) and Mn, Cu dual doped ZnS (Zn0.95Mn0.03Cu0.02S) QDs have been prepared using co-precipitation technique. The influence of Mn and Cu addition on the morphology, structure and photoluminescence properties of Mn/Cu incorporated ZnS have been examined. Cubic structure of the synthesized samples was confirmed by X-ray diffraction patterns. The incorporation of Cu in Zn-Mn-S lattice not only decreased the particle/grain size and also generates more defect based luminescent activation centres. The reduced energy gap by Mn addition was explained by sp-d exchange interaction and the elevated energy gap in Cu, Mn dual doped ZnS was expalined by Burstein–Moss effect. The tuning phenomenon of size as well as the energy gap in ZnS by Mn/Cu addition promote these materials for nano-electronic applications. FTIR spectra confirmed the presence of Mn/Cr-Zn-S bondings. The substitution of Mn /Cu provides an effective control over tuning of different emission colours which signifies their applications like light emitting diodes.

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Optical properties and toxicity of undoped and Mn-doped ZnS semiconductor nanoparticles synthesized through the aqueous route

Cited by 51 publications

References 49 publications

Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots

Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots

Mn-DOPPED ZnS QUANTUM DOTS AS SENSITIVE SENSOR FOR DETERMINATION OF CIPROFLOXACIN IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

Band Gap Tailoring, Size Modulation and Photoluminescence Properties of Mn/Cu doped ZnS Nanostructures

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Optical properties and toxicity of undoped and Mn-doped ZnS semiconductor nanoparticles synthesized through the aqueous route

Cited by 51 publications

References 49 publications

Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots

Effect of Micelle Encapsulation on Toxicity of CdSe/ZnS and Mn-Doped ZnSe Quantum Dots

Mn-DOPPED ZnS QUANTUM DOTS AS SENSITIVE SENSOR FOR DETERMINATION OF CIPROFLOXACIN IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

Band Gap Tailoring, Size Modulation and Photoluminescence Properties of Mn/Cu doped ZnS&nbsp;Nanostructures

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Band Gap Tailoring, Size Modulation and Photoluminescence Properties of Mn/Cu doped ZnS Nanostructures