Hybrid solar cells based on conductive polymer poly(o-toludine) (POT) with Cadmium Selenide nanoparticles (CdSe NPs) bulk heterojunctions (BHJ) were prepared by the direct mixing method and then the optical properties of the prepared materials were analyzed. The photovoltaic response of a hybrid film is studied by I –V measurements under simulated one-sun AM 1.5 illumination (100 mW cm-2). Three different CdSe load was tested to study the effect of CdSe loading on optical properties and efficiency of solar cell. Best ratio was 1:1 were gave 0.28 % efficiency. Also no photovoltaic effect for device with 75% CdSe load.