“…Chemometrics, as it is called, is therelatively new discipline that uses these methods to extract information efficiently from chemical data or to optimize or design chemical experiments (for a review see [22]. Assuming the parameters matrix, Y, and the data matrix, X, are linearly related, we obtain the following calibration model in matrix notation [27], Y=XC+E (2) whereY isofdimension[n xml, Xis [n xp], C is [px mJandEis[nx mJ. In general, univariate calibration methods use the signalresponse as afunction ofsomeindependentvariable atasingle, chosen value.…”