Optical sensing system based on wireless paired emitter detector diode device and ionogels for lab-on-a-disc water quality analysis

Czugala, Monika; Gorkin, Robert; Phelan, Thomas; Gaughran, Jennifer; Curto, Vincenzo F.; Ducrée, Jens; Diamond, Dermot; Benito‐Lopez, Fernando

doi:10.1039/c2lc40781g

Cited by 58 publications

(44 citation statements)

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“…4). 96 Such a device consists of two light emitting diodes, one serving as the light source and the other, in reverse bias mode, as the light detector. 96 Note that both types of the ionogels were prepared by cross-linking of the corresponding monomers in [P6, 6,6,14]DCA and [P4,4,4,4]DCA (DCA -diacetylamide).…”

Section: ·3 Optical Methods For the Registration Of The Analytical Smentioning

confidence: 99%

“…95 The paired emitter detector diode platform for lab-on-disc water quality analysis has a great potential for samples with a relatively high level of solid particles. 96 Plastic reusable pH indicator strips prepared using PILs were found to be stable in both aqueous and organic solutions. 57 The attractive features of the developed pH indicator strips are their reusability, enhanced pH-responsive color changes, and pH-response reversibility in aqueous and organic solutions (Fig.…”

Section: Application Of the Developed Optical Sensors In Chemical Anamentioning

confidence: 99%

“…4). 96 The developed chemical barcode microfluidic platforms that incorporate IL are capable of defining the pH of sweat with an accuracy of ~0.49 pH units. 95 The paired emitter detector diode platform for lab-on-disc water quality analysis has a great potential for samples with a relatively high level of solid particles.…”

Section: Application Of the Developed Optical Sensors In Chemical Anamentioning

confidence: 99%

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Applications of Ionic Liquids for the Development of Optical Chemical Sensors and Biosensors

et al. 2017

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This paper reviews the primary literature reporting the use of ionic liquids (ILs) in optical sensing technologies. The optical chemical sensors that have been developed with the assistance of ILs are classified according to the type of resultant material. Key aspects of applying ILs in such sensors are revealed and discussed. They include using ILs as solvents for the synthesis of sensor matrix materials; additives in polymer matrices; matrix materials; modifiers of the surfaces; and multifunctional sensor components. The operational principles, design, texture, and analytical characteristics of the offered sensors for determining CO2, O2, metal ions, CN -, and various organic compounds are critically discussed. The key advantages and disadvantages of using ILs in optical sensing technologies are defined. Finally, the applicability of the described materials for chemical analysis is evaluated, and possibilities for their further modernization are outlined.

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Section: ·3 Optical Methods For the Registration Of The Analytical Smentioning

confidence: 99%

Section: Application Of the Developed Optical Sensors In Chemical Anamentioning

confidence: 99%

Section: Application Of the Developed Optical Sensors In Chemical Anamentioning

confidence: 99%

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Applications of Ionic Liquids for the Development of Optical Chemical Sensors and Biosensors

et al. 2017

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“…Unlike the first generation system, 29 CMAS employs not only colorimetric chemical detection, but also centrifugal disc spinning, enabling on site sample manipulation analysis. CMAS has a modular design with easily interchangeable optical detection units, which allow any colorimetric reagent based assay to be implemented.…”

Section: 21mentioning

confidence: 99%

CMAS: fully integrated portable centrifugal microfluidic analysis system for on-site colorimetric analysis

et al. 2013

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A portable, wireless system capable of in-situ reagent-based colorimetric analysis is demonstrated. The system is based on a reconfigurable low cost optical detection method employing a paired emitter detector diode device, which allows a wide range of centrifugal microfluidic layouts to be implemented. Due to the wireless communication, acquisition parameters can be controlled remotely and results can be downloaded in distant locations and displayed in real time. The stand-alone capabilities of the system, combined with the portability and wireless communication, provide the flexibility crucial for on-site water monitoring.The centrifugal microfluidic disc presented here is designed for nitrite detection in water samples, as a proof of principle. A limit of detection of 9.31 ppb, along with similar coefficient of correlation and precision, were obtained from the Centrifugal Microfluidic Analysis System compared with the same parameters measured using a UV-Vis spectrophotometer.

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“…Over the last two decades, various microfluidic "lab-on-a-disc" (LoaD) platforms have proven to facilitate full integration and automation of laboratory unit operations such as blood separation, metering, aliquoting, mixing, reagent storage and sequential reagent delivery Duford et al 2013;Honda et al 2005;Kim et al 2013;Robert et al 2013;Steigert et al 2007;van Oordt et al 2013) for applications in bioprocess, (Nwankire et al 2013) biomedical, (Godino et al 2013;Park et al 2012) food allergen (Tortajada-Genaro et al 2011), pathogen detection (Golden et al 2013) and environmental monitoring. (Czugala et al 2012;Hwang et al 2013) Nevertheless, few examples of portable sample-to-answer systems with optical read-out have been demonstrated. (Abaxis 2012;Lee et al 2009) A standard computer DVD drive has been proposed for a range of applications including cell counting, food allergen tests and blood analysis.…”

Section: Introductionmentioning

confidence: 99%

A portable centrifugal analyser for liver function screening

Nwankire

Czugala

Burger

et al. 2014

Biosensors and Bioelectronics

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Mortality rates of up to 50% have been reported after liver failure due to drug-induced hepatotoxicity and certain viral infections (Gao et al. 2008). These adverse conditions frequently affect HIV and tuberculosis patients on regular medication in resource-poor settings. Here, we report full integration of sample preparation with read-out of a 5-parameter liver assay panel (LAP) on a portable, easy-to-use, fast and costefficient centrifugal microfluidic analysis system (CMAS). Our unique, dissolvable-film based centrifugopneumatic valving was employed to provide sample-to-answer fashion automation for plasma extraction (from finger-prick of blood), metering and aliquoting into separate reaction chambers for parallelized colorimetric quantification during rotation. The entire LAP completes in less than 20 minutes while using only a tenth the reagent volumes when compared with standard hospital laboratory tests. Accuracy of in-situ liver function screening was validated by 96 separate tests with an average coefficient of variance (CV) of 7.9% compared to benchtop and hospital lab tests. Unpaired two sample statistical t-tests were used to compare the means of CMAS and benchtop reader, on one hand; and CMAS and hospital tests on the other. The results demonstrate no statistical difference between the respective means with 94% and 92% certainty of equivalence, respectively. The portable platform thus saves significant time, labour and costs compared to established technologies, and therefore comply with typical restrictions on lab infrastructure, maintenance, operator skill and costs prevalent in many field clinics of the developing world. It has been successfully deployed in a centralised lab in Nigeria. IntroductionLiver is the largest solid organ in the body and is largely responsible for metabolism and detoxification. (Gao et al. 2008) Liver function tests are widely used in clinical chemistry to assess therapeutic effects and potential medication-induced liver damage, especially when taking medications for HIV, tuberculosis and cancer. (Landis et al. 2013;Rahmioglu et al. 2009; Vella et al. 2012) Literature reports suggest that a mortality rate of 2 -28% can be linked with medication-induced liver damage. (Vella et al. 2012) As a result, monitoring of liver function when on certain medications has become common practice in developed countries but can be expensive in poor resource areas. This has prompted local governments and international funding agencies to set up centralised laboratories for liver function monitoring tests especially for HIV patients. Nonetheless, transport logistics and accessibility remains a significant challenge for the majority of these patients. Thus it is very important to develop portable point-of-care (PoC) devices that could be used for liver function screening in the field. Currently, there are only a handful of sample-to-answer PoC devices available for deployment in the field. Recently, Vella et al.(Vella et al. 2012) demonstrated an innovative micropatterned paper device fo...

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Optical sensing system based on wireless paired emitter detector diode device and ionogels for lab-on-a-disc water quality analysis

Cited by 58 publications

References 50 publications

Applications of Ionic Liquids for the Development of Optical Chemical Sensors and Biosensors

Applications of Ionic Liquids for the Development of Optical Chemical Sensors and Biosensors

CMAS: fully integrated portable centrifugal microfluidic analysis system for on-site colorimetric analysis

A portable centrifugal analyser for liver function screening

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