Optical sensor based on Fabry-Perot resonance modes

Liu, Xuanbin; Cao, Zhang; Shen, Qishun; Huang, Shu Pin

doi:10.1364/ao.42.007137

Cited by 12 publications

(3 citation statements)

References 13 publications

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“…One is to make use of the linear region of the resonant dip [24, 25], as Equation (12) shows; the other is to transform the differential intensity ratio change to the resonant wavelength shift directly by the reversed Lorentz formula (Equation (13)), as the resonant dip can be well fitted by a Lorentzian lineshape (as shown in Figure 3(c)). The latter one makes it easier to determine the bulk solvent refractive index change or molecular binding in real time.…”

Section: Methodsmentioning

confidence: 99%

Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry

Guo

Divin

et al. 2009

SPIE Proceedings

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A novel optical biosensor using a one-dimensional photonic crystal structure in a total-internalreflection geometry (PC-TIR) is presented and investigated for label-free biosensing applications. This simple configuration forms a micro Fabry-Perot resonator in the top layer which provides a narrow optical resonance to enable label-free, highly sensitive measurements for the presence of analytes on the sensing surface or the refractive index change of the surrounding medium in the enhanced evanescent field; and at the same time it employs an open sensing surface for real-time biomolecular binding detection. The high sensitivity of the sensor was experimentally demonstrated by bulk solvent refractive index changes, ultrathin molecular films adsorbed on the sensing surface, and real-time analytes binding, measuring both the spectral shift of the photonic crystal resonance and the change of the intensity ratio in a differential reflectance measurement. Detection limits of 7×10 −8 RIU for bulk solvent refractive index, 6×10 −5 nm for molecular layer thickness and 24 fg/mm 2 for mass density were obtained, which represent a significant improvement relative to state-of-the-art surface-plasmon-resonance (SPR)-based systems. The PC-TIR sensor is thus seen to be a promising technology platform for high sensitivity and accurate biomolecular detection.

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Section: Methodsmentioning

confidence: 99%

Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry

Guo

Divin

et al. 2009

SPIE Proceedings

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“…By adjusting the incident angle, one can tune the resonance dip to the desired wavelength. For the experiments reported here, the incident angle was adjusted to 63.74° to tune the resonant wavelength to 632.0nm, so that a HeNe laser at 632.8 nm lies in the linear region of the resonant dip [23, 24] and could be used to detect the resonance shift with molecular binding.…”

Section: Methodsmentioning

confidence: 99%

Sensitive molecular binding assay using a photonic crystal structure in total internal reflection

Guo¹,

Divin²,

Myc³

et al. 2008

Opt. Express

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A novel optical sensor for label-free biomolecular binding assay using a one-dimensional photonic crystal in a total-internal-reflection geometry is proposed and demonstrated. The simple configuration provides a narrow optical resonance to enable sensitive measurements of molecular binding, and at the same time employs an open interface to enable real-time measurements of binding dynamics. Ultrathin aminopropyltriethoxysilane/glutaraldehyde films adsorbed on the interface were detected by measuring the spectral shift of the photonic crystal resonance and the intensity ratio change in a differential reflectance measurement. A detection limit of 6×10 −5 nm for molecular layer thickness was obtained, which corresponds to a detection limit for analyte adsorption of 0.06 pg/mm 2 or a refractive index resolution of 3×10 −8 RIU; this represents a significant improvement relative to state-of-the-art surface-plasmon-resonance-based systems.

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“…These methods include evanescent wave optical biosensors, interferometric biosensors, surface plasmon resonance (SPR) biosensors, quartz crystal microbalance (QCM) biosensors, and electrochemistry biosensors, etc. 1,5,9,10 . Of these various techniques, the use of the SPR biosensor has become standard practice in the investigation of molecular interactions because it is extremely sensitive to the plasmon resonance caused by environmental changes and does not require extrinsic biomolecular labeling 1 .…”

Section: Introductionmentioning

confidence: 99%

Study the enhancement of near electro-magnetic field via plasmonic effects using finite-difference time-domain method and near-field scanning optical microscopy

2006

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In this study, we use the finite-difference time-domain (FDTD) method, the attenuated-total-reflection (ATR) fluorescent and the near field scanning optical microscopy (NSOM) to investigate into the enhancement of near electro-magnetic field via plasmonic effects. In order to enhance the near electro-magnetic (EM) field on the sensing surface, a metal particle layer is added under the Kretschmann configuration of the conventional surface plasmon resonance (SPR) sensor based on the attenuated-total-reflection method. The affiliation by the simulation and experimental results can help us to understand the mechanisms of surface plasmons and particle plasmons on the sensor surface, and the effects of the EM field enhancement are classified as the surface plasmon effect, particle plasmon effect, interparticle coupling effect, and gap mode effect. With the helps of the both techniques, we can understand more about the plasmonic effects in order to deign a novel ultrahigh-resolution plasmonic biosensor.

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Optical sensor based on Fabry-Perot resonance modes

Cited by 12 publications

References 13 publications

Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry

Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry

Sensitive molecular binding assay using a photonic crystal structure in total internal reflection

Study the enhancement of near electro-magnetic field via plasmonic effects using finite-difference time-domain method and near-field scanning optical microscopy

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